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name Structure Reference Source Properties Activities Metabolism

None

AlkaPlorer ID: AK323971

Synonym: None

IUPAC Name: 2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile

Structure

SMILES: CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=C4C=CN=C4NC=N3)C=N2)C1

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InChI: InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)

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InChIKey: XUZMWHLSFXCVMG-UHFFFAOYSA-N

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Reference

PubChem CID: 73296782

CAS: 1187594-09-7

NPASS: NPC485883

Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 371.426

TPSA？: 120.56

MolLogP？: 1.0472800000000002

Number of H-Donors: 1

Number of H-Acceptors: 7

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens 26S protease regulatory subunit 6B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Acetylcholinesterase AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Actin-related protein 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Actin-related protein 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Activin receptor type-1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Activin receptor type-1B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Activin receptor type-2B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Acyl-CoA dehydrogenase family member 10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Acyl-CoA dehydrogenase family member 11 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Adaptor-associated kinase IC50 17.0 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens Adaptor-associated kinase Kd 8.2 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens Adaptor-associated kinase Kd 8.2 nM 10.1021/acs.jmedchem.1c00302
Homo sapiens Adaptor-associated kinase Kd 8.2 nM 10.1021/acs.jmedchem.1c00472
Homo sapiens Adaptor-associated kinase Kd 8.2 nM 10.1021/acs.jmedchem.1c01966
Homo sapiens Adaptor-associated kinase Kd 46.0 nM 10.1126/science.aan4368
Homo sapiens Adenine phosphoribosyltransferase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Adenylate kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ADP/ATP translocase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ADP/ATP translocase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Aldehyde oxidase Activity nan None 10.1021/acs.jmedchem.9b01895
Homo sapiens Alpha-1a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens AMP-activated protein kinase, gamma-1 subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens AMP-activated protein kinase, gamma-2 subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens ATP-dependent RNA helicase DDX1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ATP-dependent RNA helicase DDX3X Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ATP-dependent RNA helicase DDX42 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ATP-dependent RNA helicase DHX30 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens BMP-2-inducible protein kinase Kd 20.0 nM 10.1021/acs.jmedchem.1c00472
Homo sapiens BMP-2-inducible protein kinase Kd 20.0 nM 10.1021/acs.jmedchem.1c01966
Homo sapiens BMP-2-inducible protein kinase Kd 216.0 nM 10.1126/science.aan4368
Homo sapiens Bone morphogenetic protein receptor type-1A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Bone morphogenetic protein receptor type-1B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Bone morphogenetic protein receptor type-2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Brain glycogen phosphorylase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Breakpoint cluster region protein Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CaM kinase I gamma Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CaM kinase II delta Kd 312.0 nM 10.1126/science.aan4368
Homo sapiens CaM kinase II gamma Kd 243.0 nM 10.1126/science.aan4368
Homo sapiens CaM kinase IV Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CaM-kinase kinase beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Kd 3597.0 nM 10.1126/science.aan4368
Homo sapiens cAMP-dependent protein kinase beta-1 catalytic subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cAMP-dependent protein kinase, gamma catalytic subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cAMP-dependent protein kinase type II-alpha regulatory subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I delta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I epsilon Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I gamma 1 Kd 1753.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I gamma 2 Kd 265.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase II alpha (prime) Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I isoform gamma-3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cGMP-dependent protein kinase 1 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Chaperone activity of bc1 complex-like, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Chromodomain-helicase-DNA-binding protein 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Citron Rho-interacting kinase Kd 4361.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 12 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 13 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 9 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cysteine--tRNA ligase, cytoplasmic Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cytochrome c1, heme protein, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens dCTP pyrophosphatase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Delta(24)-sterol reductase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Deoxycytidine kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Discoidin domain-containing receptor 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DnaJ homolog subfamily A member 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DNA replication licensing factor MCM4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DNA topoisomerase II alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DNA topoisomerase II beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity protein kinase CLK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity protein kinase CLK3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity protein kinase CLK4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity testis-specific protein kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificty protein kinase CLK1 Kd 778.0 nM 10.1126/science.aan4368
Homo sapiens Dynamin-like 120 kDa protein, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Electron transfer flavoprotein subunit beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Elongation factor Tu, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-B receptor 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-B receptor 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-B receptor 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-B receptor 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Epidermal growth factor receptor erbB1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Epithelial discoidin domain-containing receptor 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Eukaryotic peptide chain release factor GTP-binding subunit ERF3B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Eukaryotic translation initiation factor 2-alpha kinase 1 Kd 335.0 nM 10.1126/science.aan4368
Homo sapiens Eukaryotic translation initiation factor 5B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Exosome RNA helicase MTR4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ferrochelatase, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Fibroblast growth factor receptor 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Focal adhesion kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens General transcription and DNA repair factor IIH helicase subunit XPD Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Glycine--tRNA ligase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Glycogen synthase kinase-3 alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Glycogen synthase kinase-3 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens G-protein coupled receptor kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens G protein-coupled receptor kinase 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens GTP-binding nuclear protein Ran Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Guanine nucleotide-binding protein G(i) subunit alpha-2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Heme oxygenase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Hepatocyte growth factor receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition -22.99 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 1.75 % 10.6019/CHEMBL4808148
Homo sapiens Inhibitor of nuclear factor kappa B kinase epsilon subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Inosine-5'-monophosphate dehydrogenase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Insulin-like growth factor I receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Insulin receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Interleukin-1 receptor-associated kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Interleukin-1 receptor-associated kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Interleukin-1 receptor-associated kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Isoleucine--tRNA ligase, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens JAK1/JAK2/TYK2 IC50 16.0 nM 10.1021/acs.jmedchem.5b01857
Homo sapiens JAK1/JAK2/TYK2 IC50 21.1 nM 10.1021/jm401490p
Homo sapiens JAK1/TYK2 IC50 15.0 nM 10.1021/acs.jmedchem.5b01857
Homo sapiens JAK1/TYK2 IC50 28.7 nM 10.1021/jm401490p
Homo sapiens JAK1/TYK2 IC50 29.0 nM 10.1021/acs.jmedchem.7b01598
Homo sapiens JAK2/TYK2 IC50 81.9 nM 10.1021/jm401490p
Homo sapiens JAK2/TYK2 IC50 149.0 nM 10.1021/jm401490p
Homo sapiens JAK2/TYK2 IC50 200.0 nM 10.1021/acs.jmedchem.5b01857
Homo sapiens JAK3/JAK1 IC50 67.0 nM 10.1021/acs.jmedchem.5b01857
Homo sapiens JAK3/JAK1 IC50 259.0 nM 10.1021/jm401490p
Homo sapiens JAK3/JAK1 IC50 562.0 nM 10.1016/j.ejmech.2021.113394
Homo sapiens LIM domain kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens LIM domain kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Liver CL 8.0 mL.min-1.g-1 10.1021/acs.jmedchem.7b01598
Homo sapiens Liver glycogen phosphorylase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Long-chain-fatty-acid--CoA ligase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Macrophage-stimulating protein receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase-activated protein kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase-activated protein kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase-activated protein kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase ERK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase ERK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase p38 alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase p38 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Kd 125.0 nM 10.1126/science.aan4368
Homo sapiens Maternal embryonic leucine zipper kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Membrane-associated progesterone receptor component 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Midasin Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Misshapen-like kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase 15 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase 7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 1 Kd 1891.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 11 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mixed lineage kinase 7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Multifunctional protein ADE2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Myosin-10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Myosin-14 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Myosin light chain kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Myosin light chain kinase, smooth muscle Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Non-receptor tyrosine-protein kinase TNK1 Kd 622.0 nM 10.1126/science.aan4368
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens NUAK family SNF1-like kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Nucleolar GTP-binding protein 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Obg-like ATPase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens PAS domain-containing serine/threonine-protein kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Peroxisomal acyl-coenzyme A oxidase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Peroxisomal acyl-coenzyme A oxidase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phenylalanine--tRNA ligase beta subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphatidylethanolamine-binding protein 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphofructokinase platelet type Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphorylase kinase gamma subunit 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Platelet-derived growth factor receptor beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Probable ATP-dependent RNA helicase DDX6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein kinase C alpha Kd 2071.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C beta Kd 26324.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C delta Kd 1075.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C iota Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C nu Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C theta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase N1 Kd 104.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase N2 Kd 269.0 nM 10.1126/science.aan4368
Homo sapiens Protein tyrosine kinase 2 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Putative heat shock protein HSP 90-beta 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Pyridoxal kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Quinone reductase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Rab-like protein 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ras-related protein Rab-10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ras-related protein Rab-27A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ras-related protein Rab-6A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Receptor-interacting serine/threonine-protein kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Rho-associated protein kinase 1 Kd 482.0 nM 10.1126/science.aan4368
Homo sapiens Rho-associated protein kinase 2 Kd 756.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens RNA cytidine acetyltransferase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens S-adenosylmethionine synthase isoform type-2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Septin-9 Kd 84.0 nM 10.1126/science.aan4368
Homo sapiens Serine-protein kinase ATR Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 11 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 16 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 24 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 38-like Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase AKT Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase AKT2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase AKT3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase A-Raf Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Aurora-A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Aurora-B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase B-raf Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Chk1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase c-TAK1 Kd 104.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase D2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase/endoribonuclease IRE1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase/endoribonuclease IRE2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase GAK IC50 136.0 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens Serine/threonine-protein kinase GAK Kd 120.0 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens Serine/threonine-protein kinase GAK Kd 120.0 nM 10.1021/acs.jmedchem.1c00302
Homo sapiens Serine/threonine-protein kinase GAK Kd 120.0 nM 10.1021/acs.jmedchem.1c00472
Homo sapiens Serine/threonine-protein kinase GAK Kd 120.0 nM 10.1021/acs.jmedchem.1c01966
Homo sapiens Serine/threonine-protein kinase GAK Kd 4862.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase ICK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase ILK-1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase LATS1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MRCK-A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MRCK beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MRCK gamma Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MST1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MST2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MST4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Nek1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase NEK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Nek3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase NEK9 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine protein kinase NLK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PAK 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PAK 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PAK6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PCTAIRE-2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PIM1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PLK4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase receptor R3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase RIPK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase SIK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase SIK3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TAO1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TAO2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TAO3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TBK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase ULK1 Kd 810.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase ULK3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase WEE1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Signal recognition particle receptor subunit alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Signal transducer and activator of transcription 3 IC50 20.0 nM 10.1016/j.ejmech.2020.112155
Homo sapiens Signal transducer and activator of transcription 3 IC50 44.0 nM 10.1016/j.ejmech.2020.112155
Homo sapiens STE20-related kinase adapter protein alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Structural maintenance of chromosomes protein 1A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Structural maintenance of chromosomes protein 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TGF-beta receptor type I Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TGF-beta receptor type II Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thyroid hormone receptor-associated protein 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TP53-regulating kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TRAF2- and NCK-interacting kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine- and threonine-specific cdc2-inhibitory kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine kinase non-receptor protein 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase ABL Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase ABL2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase BRK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase BTK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase CSK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FER Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FES Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FRK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FYN Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase HCK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase JAK1 IC50 0.99 nM 10.1021/acs.jmedchem.5b01857
Homo sapiens Tyrosine-protein kinase JAK1 IC50 4.0 nM 10.1016/j.bmc.2016.04.030
Homo sapiens Tyrosine-protein kinase JAK1 IC50 4.0 nM 10.1016/j.ejmech.2021.113394
Homo sapiens Tyrosine-protein kinase JAK1 IC50 4.0 nM 10.1021/acs.jmedchem.7b01598
Homo sapiens Tyrosine-protein kinase JAK1 IC50 4.0 nM 10.1021/jm401490p
Homo sapiens Tyrosine-protein kinase JAK1 IC50 4.0 nM 10.1039/d2md00206j
Homo sapiens Tyrosine-protein kinase JAK1 IC50 5.9 nM 10.1016/j.bmc.2019.03.048
Homo sapiens Tyrosine-protein kinase JAK1 IC50 5.9 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens Tyrosine-protein kinase JAK1 IC50 5.9 nM 10.1021/acs.jmedchem.0c01511
Homo sapiens Tyrosine-protein kinase JAK1 IC50 5.9 nM 10.1021/acs.jmedchem.1c00472
Homo sapiens Tyrosine-protein kinase JAK1 IC50 5.9 nM 10.1021/acs.jmedchem.1c01966
Homo sapiens Tyrosine-protein kinase JAK1 IC50 6.0 nM 10.1021/acs.jmedchem.5b01263
Homo sapiens Tyrosine-protein kinase JAK1 INH 0.006 uM 10.1016/j.bmcl.2015.09.020
Homo sapiens Tyrosine-protein kinase JAK1 INH 0.017 uM 10.1016/j.bmcl.2015.09.020
Homo sapiens Tyrosine-protein kinase JAK1 Inhibition 94.3 % 10.1016/j.bmc.2019.07.037
Homo sapiens Tyrosine-protein kinase JAK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase JAK2 Delta Tm 5.2 degrees C 10.1021/acs.jmedchem.0c01952
Homo sapiens Tyrosine-protein kinase JAK2 IC50 0.29 nM 10.1021/acs.jmedchem.0c01952
Homo sapiens Tyrosine-protein kinase JAK2 IC50 0.8 nM 10.1021/acs.jmedchem.5b01857
Homo sapiens Tyrosine-protein kinase JAK2 IC50 5.7 nM 10.1016/j.bmc.2019.03.048
Homo sapiens Tyrosine-protein kinase JAK2 IC50 5.7 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens Tyrosine-protein kinase JAK2 IC50 5.7 nM 10.1021/acs.jmedchem.0c01511
Homo sapiens Tyrosine-protein kinase JAK2 IC50 5.7 nM 10.1021/acs.jmedchem.1c00472
Homo sapiens Tyrosine-protein kinase JAK2 IC50 5.7 nM 10.1021/acs.jmedchem.1c01966
Homo sapiens Tyrosine-protein kinase JAK2 IC50 6.0 nM 10.1021/acs.jmedchem.5b01263
Homo sapiens Tyrosine-protein kinase JAK2 IC50 6.6 nM 10.1021/jm401490p
Homo sapiens Tyrosine-protein kinase JAK2 IC50 6.6 nM 10.1039/d2md00206j
Homo sapiens Tyrosine-protein kinase JAK2 IC50 7.0 nM 10.1016/j.bmc.2016.04.030
Homo sapiens Tyrosine-protein kinase JAK2 IC50 7.0 nM 10.1016/j.ejmech.2021.113394
Homo sapiens Tyrosine-protein kinase JAK2 IC50 7.0 nM 10.1021/acs.jmedchem.7b01598
Homo sapiens Tyrosine-protein kinase JAK2 IC50 87.8 nM 10.1021/jm401490p
Homo sapiens Tyrosine-protein kinase JAK2 IC50 88.0 nM 10.1021/acs.jmedchem.7b01598
Homo sapiens Tyrosine-protein kinase JAK2 IC50 290.0 nM 10.1021/acs.jmedchem.5b01857
Homo sapiens Tyrosine-protein kinase JAK2 IC50 470.0 nM 10.1016/j.ejmech.2021.113394
Homo sapiens Tyrosine-protein kinase JAK2 INH 0.006 uM 10.1016/j.bmcl.2015.09.020
Homo sapiens Tyrosine-protein kinase JAK2 INH 0.31 uM 10.1016/j.bmcl.2015.09.020
Homo sapiens Tyrosine-protein kinase JAK2 Inhibition 96.0 % 10.1016/j.bmc.2019.07.037
Homo sapiens Tyrosine-protein kinase JAK2 Inhibition nan % 10.1016/j.bmc.2016.04.030
Homo sapiens Tyrosine-protein kinase JAK2 Inhibition nan % 10.1016/j.ejmech.2021.113394
Homo sapiens Tyrosine-protein kinase JAK3 IC50 25.0 nM 10.1021/acs.jmedchem.5b01857
Homo sapiens Tyrosine-protein kinase JAK3 IC50 400.0 nM 10.1016/j.bmc.2019.03.048
Homo sapiens Tyrosine-protein kinase JAK3 IC50 400.0 nM 10.1021/acs.jmedchem.5b01263
Homo sapiens Tyrosine-protein kinase JAK3 IC50 560.0 nM 10.1016/j.bmc.2019.03.048
Homo sapiens Tyrosine-protein kinase JAK3 IC50 787.0 nM 10.1016/j.bmc.2016.04.030
Homo sapiens Tyrosine-protein kinase JAK3 IC50 787.0 nM 10.1016/j.ejmech.2021.113394
Homo sapiens Tyrosine-protein kinase JAK3 IC50 787.0 nM 10.1021/jm401490p
Homo sapiens Tyrosine-protein kinase JAK3 IC50 8000.0 nM 10.1021/acs.jmedchem.7b01598
Homo sapiens Tyrosine-protein kinase JAK3 INH 0.18 uM 10.1016/j.bmcl.2015.09.020
Homo sapiens Tyrosine-protein kinase LCK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase Lyn Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase receptor RET Kd 973.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase SRC Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase SYK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase TEC Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase TYK2 IC50 8.7 nM 10.1021/acs.jmedchem.5b01857
Homo sapiens Tyrosine-protein kinase TYK2 IC50 53.0 nM 10.1016/j.bmc.2019.03.048
Homo sapiens Tyrosine-protein kinase TYK2 IC50 53.0 nM 10.1021/acs.jmedchem.5b01263
Homo sapiens Tyrosine-protein kinase TYK2 IC50 61.0 nM 10.1016/j.ejmech.2021.113394
Homo sapiens Tyrosine-protein kinase TYK2 IC50 61.0 nM 10.1021/jm401490p
Homo sapiens Tyrosine-protein kinase TYK2 IC50 200000.0 nM 10.1021/acs.jmedchem.7b01598
Homo sapiens Tyrosine-protein kinase TYK2 INH 0.036 uM 10.1016/j.bmcl.2015.09.020
Homo sapiens Tyrosine-protein kinase TYK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase YES Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosyl-tRNA synthetase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens U5 small nuclear ribonucleoprotein 200 kDa helicase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens UMP-CMP kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Uncharacterized aarF domain-containing protein kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Uncharacterized aarF domain-containing protein kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Uncharacterized protein FLJ45252 Kd 78.0 nM 10.1126/science.aan4368
Homo sapiens Very long-chain specific acyl-CoA dehydrogenase, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Mus musculus RAW264.7 Activity nan None 10.1016/j.bmc.2019.07.037
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Rattus norvegicus Activity 50.0 % 10.1016/j.ejmech.2020.112155
Rattus norvegicus Rattus norvegicus Activity 95.0 % 10.1016/j.ejmech.2020.112155
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 22.48 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 57.54 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 100.03 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Activity 30.0 % 10.1021/acs.jmedchem.0c01467
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.05063 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 50100.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 50118.72 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -5.93 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.26 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.09 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.03 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome-related coronavirus SARS-CoV Activity 30.0 % 10.1021/acs.jmedchem.1c00335
None ADMET AUC 1586.81 ng.hr.mL-1 10.1016/j.ejmech.2021.113394
None ADMET AUC 3608.48 ng.hr.mL-1 10.1016/j.ejmech.2021.113394
None ADMET CC50 5000.0 nM 10.1021/acs.jmedchem.0c01467
None ADMET CL 10.5 mL.min-1.kg-1 10.1016/j.ejmech.2021.113394
None ADMET CL 23.17 mL.min-1.kg-1 10.1016/j.ejmech.2021.113394
None ADMET Cmax 1774.76 nM 10.1016/j.ejmech.2021.113394
None ADMET F 45.48 % 10.1016/j.ejmech.2021.113394
None ADMET LogD 0.24 None 10.1016/j.ejmech.2021.113394
None ADMET MRT 1.34 hr 10.1016/j.ejmech.2021.113394
None ADMET MRT 4.36 hr 10.1016/j.ejmech.2021.113394
None ADMET Stability 96.12 % 10.1016/j.ejmech.2021.113394
None ADMET T1/2 1.96 hr 10.1016/j.ejmech.2021.113394
None ADMET T1/2 2.43 hr 10.1016/j.ejmech.2021.113394
None ADMET Tmax 1.0 hr 10.1016/j.ejmech.2021.113394
None ADMET Vdss 1.8 L.kg-1 10.1016/j.ejmech.2021.113394
None ADMET Vdss 4.88 L.kg-1 10.1016/j.ejmech.2021.113394
None Calvarial osteoblast CC50 50000.0 nM 10.1021/acs.jmedchem.0c01467
None No relevant target LogD 1.2 None 10.1021/acs.jmedchem.7b01598
None No relevant target Solubility 16.3 ug.mL-1 10.1016/j.ejmech.2021.113394
None Unchecked Activity 34.0 % 10.1016/j.bmc.2020.115347
None Unchecked Activity nan None 10.1021/acsmedchemlett.1c00650
None Unchecked IC50 40.0 nM 10.1016/j.ejmech.2020.112155
None Unchecked IC50 50.0 nM 10.1016/j.ejmech.2020.112155
None Unchecked IC50 190.0 nM 10.1021/acs.jmedchem.0c01952
None Unchecked IC50 536.0 nM 10.1021/acsmedchemlett.1c00650
None Unchecked Kd 126.0 nM 10.1126/science.aan4368
None Unchecked Kd 3315.0 nM 10.1126/science.aan4368
None Unchecked Kd 30000.0 nM 10.1126/science.aan4368
None Unchecked Ratio IC50 1.0 None 10.1021/acs.jmedchem.5b01263
None Unchecked Ratio IC50 2.0 None 10.1021/acs.jmedchem.7b01598
None Unchecked Ratio IC50 9.0 None 10.1021/acs.jmedchem.5b01263
None Unchecked Ratio IC50 67.0 None 10.1021/acs.jmedchem.5b01263

Metabolism Information