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name Structure Reference Source Properties Activities Metabolism

None

AlkaPlorer ID: AK324313

Synonym: None

IUPAC Name: (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one

Structure

SMILES: CC1=CC(C)=C(/C=C2\C(O)=NC3=CC=CC=C23)N1

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InChI: InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-

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InChIKey: WUWDLXZGHZSWQZ-WQLSENKSSA-N

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Reference

PubChem CID: 5329098

CAS: 194413-58-6

NPASS: NPC487020

Properties Information

Molecule Weight: 238.29

TPSA？: 48.38

MolLogP？: 3.773740000000002

Number of H-Donors: 2

Number of H-Acceptors: 1

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 89125.1 nM None
Caenorhabditis elegans Cytoplasmic zinc-finger protein EC50 300000.0 nM None
Caenorhabditis elegans Zinc finger protein mex-5 EC50 300000.0 nM None
Danio rerio Danio rerio LC100 5.0 uM 10.1016/j.bmc.2018.07.037
Danio rerio Danio rerio MEC 1.0 uM 10.1016/j.bmc.2018.07.037
Danio rerio Danio rerio MED 1.25 uM 10.1016/j.bmc.2019.04.027
Danio rerio Danio rerio MTC 1.5 uM 10.1016/j.bmc.2018.07.037
Danio rerio Danio rerio Ratio 1.5 None 10.1016/j.bmc.2018.07.037
Danio rerio Danio rerio Ratio 5.0 None 10.1016/j.bmc.2018.07.037
Danio rerio Vascular endothelial growth factor receptor 2 Inhibition nan % 10.1038/nchembio778
Gallus gallus Chorioallantoic membrane IC50 60.0 nM 10.1016/j.bmc.2014.04.049
Gallus gallus Chorioallantoic membrane IC50 85.0 nM 10.1016/j.bmc.2012.12.045
Gallus gallus Chorioallantoic membrane IC50 60000.0 nM 10.1016/j.bmcl.2018.07.039
Gallus gallus Gallus gallus IC50 85.0 nM 10.1016/j.bmc.2008.04.019
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens 786-0 GI50 100000.0 nM None
Homo sapiens A-431 GI50 37000.0 nM 10.1016/j.ejmech.2018.03.013
Homo sapiens A-431 GI50 37000.0 nM 10.1021/acsmedchemlett.8b00499
Homo sapiens A-431 IC50 85.0 nM 10.1016/j.bmcl.2010.03.064
Homo sapiens A-431 IC50 19200.0 nM 10.1016/j.bmc.2008.04.019
Homo sapiens A-431 IC50 19200.0 nM 10.1016/j.bmc.2012.01.029
Homo sapiens A-431 IC50 19200.0 nM 10.1016/j.bmcl.2010.03.064
Homo sapiens A-431 IC50 nan None 10.1016/j.bmc.2014.04.049
Homo sapiens A-431 IC50 nan None 10.1016/j.bmc.2015.03.061
Homo sapiens A-431 IC50 nan None 10.1016/j.bmc.2016.11.026
Homo sapiens A-431 IC50 nan None 10.1016/j.bmcl.2018.07.039
Homo sapiens A498 GI50 100000.0 nM None
Homo sapiens A549 GI50 65313.06 nM None
Homo sapiens ACHN GI50 66221.65 nM None
Homo sapiens Activin receptor type-1B Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Activin receptor type-1B Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens ALK tyrosine kinase receptor IC50 1200.0 nM 10.1016/j.bmc.2010.01.011
Homo sapiens ALK tyrosine kinase receptor IC50 1810.0 nM 10.1016/j.bmc.2011.04.008
Homo sapiens ALK tyrosine kinase receptor Residual Activity 13.0 % 10.1042/bj20121418
Homo sapiens ALK tyrosine kinase receptor Residual Activity 37.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 29.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Ataxin-2 Potency 3548.1 nM None
Homo sapiens ATP-dependent DNA helicase Q1 Potency 15848.9 nM None
Homo sapiens Bloom syndrome protein Potency 2511.9 nM None
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 48.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens BT-549 GI50 100000.0 nM None
Homo sapiens CAKI-1 GI50 59156.16 nM None
Homo sapiens CaM kinase I alpha Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I alpha Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Residual Activity 36.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Residual Activity 38.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Residual Activity -1.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I delta Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I delta Residual Activity 13.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Residual Activity 28.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Residual Activity 51.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens CCRF-CEM GI50 100000.0 nM None
Homo sapiens CDK3/cyclin E Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens CDK3/cyclin E Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Chromobox protein homolog 1 Potency 17782.8 nM None
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens COLO 205 GI50 100000.0 nM None
Homo sapiens Cyclin-dependent kinase 1 IC50 10000.0 nM 10.1021/jm020899q
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 130.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 1 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 1 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens DNA dC->dU-editing enzyme APOBEC-3F Potency 12589.3 nM None
Homo sapiens DNA dC->dU-editing enzyme APOBEC-3F Potency 16360.1 nM None
Homo sapiens DNA dC->dU-editing enzyme APOBEC-3F Potency 18356.4 nM None
Homo sapiens DNA dC->dU-editing enzyme APOBEC-3G Potency 7079.5 nM None
Homo sapiens DNA dC->dU-editing enzyme APOBEC-3G Potency 18356.4 nM None
Homo sapiens DNA polymerase iota Potency 14125.4 nM None
Homo sapiens DNA polymerase iota Potency 89125.1 nM None
Homo sapiens Dopamine D1 receptor Potency 15848.9 nM None
Homo sapiens DU-145 GI50 82985.08 nM None
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 31.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 41.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 37.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 49.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 11.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens EKVX GI50 2805.43 nM None
Homo sapiens Ephrin type-A receptor 1 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 1 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Residual Activity 121.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 IC50 10000.0 nM 10.1021/jm020899q
Homo sapiens Epidermal growth factor receptor erbB1 IC50 50000.0 nM 10.1021/jm9904295
Homo sapiens Epidermal growth factor receptor erbB1 IC50 100000.0 nM 10.1021/jm0204183
Homo sapiens Epidermal growth factor receptor erbB1 IC50 100000.0 nM 10.1021/jm980123i
Homo sapiens Epidermal growth factor receptor erbB1 IC50 100000.0 nM 10.1021/jm9904295
Homo sapiens Epidermal growth factor receptor erbB1 IC50 100000.0 nM 10.1021/jm9906116
Homo sapiens Epidermal growth factor receptor erbB1 IC50 100000.0 nM 10.1021/np300535c
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None 10.1016/j.bmc.2014.04.049
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None 10.1016/j.bmc.2015.03.061
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None 10.1016/j.bmc.2016.11.026
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None 10.1016/j.bmcl.2018.07.039
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Eyes absent homolog 2 Potency 79432.8 nM None
Homo sapiens Fibroblast growth factor receptor IC50 5000.0 nM 10.1021/np300535c
Homo sapiens Fibroblast growth factor receptor 1 IC50 4200.0 nM 10.1021/jm020899q
Homo sapiens Fibroblast growth factor receptor 1 IC50 7080.0 nM 10.1021/jm9904295
Homo sapiens Fibroblast growth factor receptor 1 IC50 7080.0 nM 10.1021/jm9906116
Homo sapiens Fibroblast growth factor receptor 1 IC50 10000.0 nM 10.1021/jm020899q
Homo sapiens Fibroblast growth factor receptor 1 IC50 50000.0 nM 10.1021/jm9904295
Homo sapiens Fibroblast growth factor receptor 1 IC50 100000.0 nM 10.1021/jm0204183
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 13.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 66.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 124.0 % 10.1042/bj20121418
Homo sapiens Focal adhesion kinase 1 Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Focal adhesion kinase 1 Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens Geminin Potency 1258.9 nM None
Homo sapiens Geminin Potency 14125.4 nM None
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 124.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 Potency 17782.8 nM None
Homo sapiens HCC 2998 GI50 38815.04 nM None
Homo sapiens HCT-116 GI50 72945.75 nM None
Homo sapiens HCT-15 GI50 34833.73 nM None
Homo sapiens HEK293 Potency 35481.3 nM None
Homo sapiens HeLa GI50 38000.0 nM 10.1016/j.ejmech.2018.03.013
Homo sapiens HeLa GI50 38000.0 nM 10.1021/acsmedchemlett.8b00499
Homo sapiens HeLa IC50 20000.0 nM 10.1016/j.ejmech.2012.10.001
Homo sapiens Hepatocyte growth factor receptor Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Hepatocyte growth factor receptor Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens HepG2 Potency 4466.8 nM None
Homo sapiens HERG Potency 7943.3 nM None
Homo sapiens Histone deacetylase 6 Inhibition 2.33 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 36.37 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 88.78 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 4466.8 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 16833.6 nM None
Homo sapiens Histone-lysine N-methyltransferase MLL Potency 31622.8 nM None
Homo sapiens Histone-lysine N-methyltransferase MLL Potency 39810.7 nM None
Homo sapiens HL-60 GI50 7277.8 nM None
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 39.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens HOP-62 GI50 82224.26 nM None
Homo sapiens HOP-92 GI50 48305.88 nM None
Homo sapiens Hs-578T GI50 19588.45 nM None
Homo sapiens HT-29 GI50 35563.13 nM None
Homo sapiens HUVEC GI50 13600.0 nM 10.1016/j.ejmech.2015.08.027
Homo sapiens HUVEC GI50 13600.0 nM 10.1021/acsmedchemlett.8b00499
Homo sapiens HUVEC IC50 40.0 nM 10.1021/jm9906116
Homo sapiens HUVEC IC50 4540.0 nM 10.1021/jm9906116
Homo sapiens HUVEC IC50 50000.0 nM 10.1021/jm9906116
Homo sapiens HUVEC Inhibition 94.0 % 10.1016/j.bmcl.2006.12.108
Homo sapiens IGROV-1 GI50 7780.37 nM None
Homo sapiens Importin subunit beta-1/Snurportin-1 Potency 14125.4 nM None
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor IC50 10000.0 nM 10.1021/jm020899q
Homo sapiens Insulin-like growth factor I receptor IC50 100000.0 nM 10.1021/jm980123i
Homo sapiens Insulin-like growth factor I receptor Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 11.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 30.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 44.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 49.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 13.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 39.0 % 10.1042/bj20121418
Homo sapiens K562 GI50 100000.0 nM None
Homo sapiens KM12 GI50 997.7 nM None
Homo sapiens LIM domain kinase 1 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens LIM domain kinase 1 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens LOX IMVI GI50 100000.0 nM None
Homo sapiens Lysine-specific demethylase 4A Potency 8912.5 nM None
Homo sapiens M14 GI50 69023.98 nM None
Homo sapiens Macrophage colony stimulating factor receptor IC50 84.0 nM 10.1021/jm020899q
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor IC50 10000.0 nM 10.1021/jm020899q
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Malme-3M GI50 58479.01 nM None
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 140.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK2 Potency 14125.4 nM None
Homo sapiens MAP kinase ERK2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 alpha Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 alpha Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 delta Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 delta Residual Activity 124.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 34.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 56.0 % 10.1042/bj20121418
Homo sapiens MCF7 GI50 83946.0 nM None
Homo sapiens MCF7 IC50 3.1 nM 10.1016/j.ejmech.2013.04.035
Homo sapiens MCF7 IC50 1900.0 nM 10.1016/j.ejmech.2012.10.001
Homo sapiens MCF7 IC50 50000.0 nM 10.1016/j.bmcl.2005.09.001
Homo sapiens MDA-MB-231 GI50 62086.9 nM None
Homo sapiens MDA-MB-231 IC50 50000.0 nM 10.1016/j.bmcl.2005.09.001
Homo sapiens MDA-MB-435 GI50 96382.9 nM None
Homo sapiens MDA-N GI50 95940.06 nM None
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 501.2 nM None
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 1778.3 nM None
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 15848.9 nM None
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 19952.6 nM None
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 22387.2 nM None
Homo sapiens Microtubule-associated protein tau Potency 3162.3 nM None
Homo sapiens Microtubule-associated protein tau Potency 4466.8 nM None
Homo sapiens Misshapen-like kinase 1 Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Misshapen-like kinase 1 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 56.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 11.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens MOLT-4 GI50 78162.78 nM None
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 15848.9 nM None
Homo sapiens M-phase phosphoprotein 8 Potency 7943.3 nM None
Homo sapiens MSTO-211H GI50 27000.0 nM 10.1016/j.ejmech.2018.03.013
Homo sapiens MSTO-211H GI50 27000.0 nM 10.1021/acsmedchemlett.8b00499
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 12.0 % 10.1042/bj20121418
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 39.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens NCI/ADR-RES GI50 100000.0 nM None
Homo sapiens NCI-H226 GI50 1224.62 nM None
Homo sapiens NCI-H23 GI50 7961.59 nM None
Homo sapiens NCI-H322M GI50 100000.0 nM None
Homo sapiens NCI-H460 GI50 57809.6 nM None
Homo sapiens NCI-H522 GI50 49888.45 nM None
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Neuropeptide S receptor Potency 12589.3 nM None
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity -7.0 % 10.1042/bj20121418
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity 40.0 % 10.1042/bj20121418
Homo sapiens Niemann-Pick C1 protein Potency 16360.1 nM None
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 19.0 % 10.1042/bj20121418
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 35.0 % 10.1042/bj20121418
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 20596.2 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 23109.3 nM None
Homo sapiens OVCAR-3 GI50 100000.0 nM None
Homo sapiens OVCAR-4 GI50 52480.75 nM None
Homo sapiens OVCAR-5 GI50 69023.98 nM None
Homo sapiens OVCAR-8 GI50 49545.02 nM None
Homo sapiens Oxytocin receptor EC50 11468.0 nM None
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens PBMC IC50 5.0 nM 10.1021/jm0504151
Homo sapiens PC-3 GI50 100000.0 nM None
Homo sapiens PC-3 IC50 50000.0 nM 10.1016/j.bmcl.2005.09.001
Homo sapiens Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Potency 26854.5 nM None
Homo sapiens Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Potency 39810.7 nM None
Homo sapiens Peripheral myelin protein 22 Potency 33807.8 nM None
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 39.0 % 10.1042/bj20121418
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor alpha IC50 200.0 nM 10.1021/np300535c
Homo sapiens Platelet-derived growth factor receptor alpha IC50 nan None 10.1039/C4MD00211C
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 15.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta IC50 68.0 nM 10.1038/nchembio778
Homo sapiens Platelet-derived growth factor receptor beta IC50 68.0 nM 10.1039/C4MD00211C
Homo sapiens Platelet-derived growth factor receptor beta IC50 400.0 nM 10.1021/np300535c
Homo sapiens Platelet-derived growth factor receptor beta IC50 680.0 nM 10.1021/jm9909443
Homo sapiens Platelet-derived growth factor receptor beta IC50 2220.0 nM 10.1021/jm020899q
Homo sapiens Platelet-derived growth factor receptor beta IC50 2400.0 nM 10.1016/j.bmc.2009.08.044
Homo sapiens Platelet-derived growth factor receptor beta IC50 4540.0 nM 10.1021/jm9904295
Homo sapiens Platelet-derived growth factor receptor beta IC50 10100.0 nM 10.1021/jm9906116
Homo sapiens Platelet-derived growth factor receptor beta IC50 10500.0 nM 10.1021/jm9904295
Homo sapiens Platelet-derived growth factor receptor beta IC50 20260.0 nM 10.1021/jm980123i
Homo sapiens Platelet-derived growth factor receptor beta IC50 22900.0 nM 10.1021/jm0204183
Homo sapiens Platelet-derived growth factor receptor beta IC50 37900.0 nM 10.1021/jm020899q
Homo sapiens Platelet-derived growth factor receptor beta IC50 nan None 10.1016/j.bmc.2014.04.049
Homo sapiens Platelet-derived growth factor receptor beta IC50 nan None 10.1016/j.bmc.2015.03.061
Homo sapiens Platelet-derived growth factor receptor beta IC50 nan None 10.1016/j.bmc.2016.11.026
Homo sapiens Platelet-derived growth factor receptor beta IC50 nan None 10.1016/j.bmcl.2018.07.039
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 23.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 43.0 % 10.1042/bj20121418
Homo sapiens Prelamin-A/C Potency 19952.6 nM None
Homo sapiens Protein kinase C alpha Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C alpha Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C theta Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C theta Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 34.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Rap guanine nucleotide exchange factor 3 Potency 15848.9 nM None
Homo sapiens Rap guanine nucleotide exchange factor 4 Potency 56234.1 nM None
Homo sapiens Rap guanine nucleotide exchange factor 4 Potency 112201.8 nM None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 100000.0 nM 10.1021/jm980123i
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 122.0 % 10.1042/bj20121418
Homo sapiens Regulator of G-protein signaling 4 Potency 9466.2 nM None
Homo sapiens Rho-associated protein kinase 1 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 1 Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 36.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 38.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 11.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 51.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 27.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 26.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 39.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 17.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 38.0 % 10.1042/bj20121418
Homo sapiens RPMI-8226 GI50 100000.0 nM None
Homo sapiens Runt-related transcription factor 1/Core-binding factor subunit beta Potency 14125.4 nM None
Homo sapiens RXF 393 GI50 100000.0 nM None
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 45.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 26.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 47.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 29.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 43.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 33.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 56.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 38.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 18.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 20.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 20.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 51.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 15.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Potency 1309.2 nM None
Homo sapiens Serine/threonine-protein kinase mTOR Potency 2896.3 nM None
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 121.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Potency 23778.1 nM None
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 67.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 134.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 15.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 53.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens SF-268 GI50 100000.0 nM None
Homo sapiens SF-295 GI50 100000.0 nM None
Homo sapiens SF-539 GI50 100000.0 nM None
Homo sapiens SH-SY5Y Potency 3548.1 nM None
Homo sapiens SK-MEL-2 GI50 75857.76 nM None
Homo sapiens SK-MEL-28 GI50 100000.0 nM None
Homo sapiens SK-MEL-5 GI50 90782.05 nM None
Homo sapiens SK-OV-3 GI50 66680.68 nM None
Homo sapiens SN12C GI50 100000.0 nM None
Homo sapiens SNB-19 GI50 100000.0 nM None
Homo sapiens SNB-75 GI50 905.73 nM None
Homo sapiens SR GI50 17864.88 nM None
Homo sapiens Stem cell growth factor receptor IC50 35.0 nM 10.1021/jm020899q
Homo sapiens Stem cell growth factor receptor IC50 400.0 nM 10.1021/jm9909443
Homo sapiens Stem cell growth factor receptor IC50 660.0 nM 10.1021/jm020899q
Homo sapiens Stem cell growth factor receptor Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Stem cell growth factor receptor Residual Activity 11.0 % 10.1042/bj20121418
Homo sapiens SW-620 GI50 87700.08 nM None
Homo sapiens T47D GI50 100000.0 nM None
Homo sapiens TAR DNA-binding protein 43 Potency 10000.0 nM None
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens TK-10 GI50 100000.0 nM None
Homo sapiens Transcriptional regulator ERG Potency 10000.0 nM None
Homo sapiens Transcriptional regulator ERG Potency 100000.0 nM None
Homo sapiens Tumor susceptibility gene 101 protein Potency 35481.3 nM None
Homo sapiens Tumor susceptibility gene 101 protein Potency 50118.7 nM None
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 18.0 % 10.1042/bj20121418
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL IC50 10000.0 nM 10.1021/jm020899q
Homo sapiens Tyrosine-protein kinase ABL IC50 11000.0 nM 10.1016/j.bmc.2010.01.011
Homo sapiens Tyrosine-protein kinase ABL Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BRK Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BRK Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 66.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 121.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Residual Activity 44.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 30.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 53.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 66.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 19.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 40.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 12.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 66.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 56.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 33.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 44.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 56.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 46.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 IC50 160.0 nM 10.1016/j.bmc.2010.01.011
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET IC50 170.0 nM 10.1016/j.bmc.2010.01.011
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 12.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 31.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC IC50 10000.0 nM 10.1021/jm020899q
Homo sapiens Tyrosine-protein kinase SRC IC50 16400.0 nM 10.1021/jm9906116
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 121.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 IC50 10000.0 nM 10.1021/jm020899q
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase YES Potency 1373.4 nM None
Homo sapiens Tyrosine-protein kinase YES Residual Activity 33.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase YES Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 IC50 20700.0 nM 10.1016/j.ejmech.2009.07.018
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 122.0 % 10.1042/bj20121418
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 6309.6 nM None
Homo sapiens U-251 GI50 100000.0 nM None
Homo sapiens UACC-257 GI50 100000.0 nM None
Homo sapiens UACC-62 GI50 100000.0 nM None
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Potency 7519.3 nM None
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Potency 15848.9 nM None
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Potency 25118.9 nM None
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 2 Potency 16481.6 nM None
Homo sapiens UO-31 GI50 34514.37 nM None
Homo sapiens Vanilloid receptor Potency 17782.8 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 8.0 nM 10.1021/jm9909443
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 43.0 nM 10.1021/jm020899q
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 43.0 nM 10.1039/C4MD00211C
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 3000.0 nM 10.1021/np300535c
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 ED50 930.0 nM 10.1021/jm9909443
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 12.9 nM 10.1016/j.bmc.2014.04.049
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 12.9 nM 10.1016/j.bmc.2015.03.061
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 12.9 nM 10.1016/j.bmc.2016.11.026
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 12.9 nM 10.1016/j.bmcl.2018.07.039
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 12.9 nM 10.1021/ml4004793
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 40.0 nM 10.1021/jm9904295
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 110.0 nM 10.1016/j.bmc.2009.09.038
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 200.0 nM 10.1016/j.bmcl.2007.01.089
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 200.0 nM 10.1021/jm9909443
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 220.0 nM 10.1021/jm020899q
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 220.0 nM 10.1038/nchembio778
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 220.0 nM 10.1039/C4MD00211C
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 230.0 nM 10.1021/jm0504151
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 700.0 nM 10.1021/jm9904295
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 700.0 nM 10.1021/jm9906116
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 884.0 nM 10.1021/jm020899q
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 1000.0 nM 10.1021/np300535c
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 1230.0 nM 10.1021/jm0204183
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 1300.0 nM 10.1021/jm020899q
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 2430.0 nM 10.1016/j.bmc.2012.01.029
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 10600.0 nM 10.1016/j.bmc.2008.04.019
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 10600.0 nM 10.1016/j.bmcl.2010.03.064
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 10600.0 nM None
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 12000.0 nM 10.1016/j.bmc.2010.03.052
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 12000.0 nM 10.1016/j.bmc.2011.11.058
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 12000.0 nM 10.1016/j.bmc.2012.12.045
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 12000.0 nM 10.1016/j.bmc.2013.01.040
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 12000.0 nM 10.1016/j.bmcl.2017.02.018
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 12900.0 nM 10.1016/j.bmc.2010.05.049
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 12900.0 nM 10.1016/j.bmc.2012.05.068
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 12900.0 nM 10.1016/j.ejmech.2015.08.027
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 12900.0 nM 10.1021/acsmedchemlett.8b00499
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 12900.0 nM 10.1021/jm9011142
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 12900.0 nM None
Homo sapiens Vascular endothelial growth factor receptor 2 Inhibition 40.0 % 10.1016/j.ejmech.2015.08.027
Homo sapiens Vascular endothelial growth factor receptor 2 Inhibition 40.0 % 10.1021/acsmedchemlett.8b00499
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 IC50 50.0 nM 10.1021/jm020899q
Homo sapiens Vascular endothelial growth factor receptor 3 IC50 500.0 nM 10.1021/np300535c
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Vasopressin V1a receptor EC50 12070.0 nM None
Influenza A virus Nonstructural protein 1 Potency 5011.9 nM None
Mus musculus B16 Inhibition nan % 10.1021/jm020899q
Mus musculus B16-F10 IC50 3.6 nM 10.1016/j.ejmech.2013.04.035
Mus musculus Fibroblast growth factor receptor 1 Inhibition 87.0 % 10.1021/jm020899q
Mus musculus Mus musculus Cmax 300000.0 nM 10.1021/jm9909443
Mus musculus Mus musculus Inhibition -98.0 % 10.1021/jm0504151
Mus musculus Mus musculus Tmax 0.5 hr 10.1021/jm9909443
Mus musculus Platelet-derived growth factor receptor IC50 4050.0 nM 10.1021/jm0204183
Mus musculus Platelet-derived growth factor receptor IC50 20260.0 nM 10.1021/jm9904295
Mus musculus Platelet-derived growth factor receptor IC50 20300.0 nM 10.1021/jm0204183
Mus musculus Vascular endothelial growth factor receptor 1 IC50 1040.0 nM 10.1021/jm980123i
Mus musculus Vascular endothelial growth factor receptor 2 IC50 1040.0 nM 10.1021/jm9904295
Plasmodium falciparum Plasmodium falciparum IC50 7943.28 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum Potency 3.3 nM None
Plasmodium falciparum Plasmodium falciparum Potency 2078.7 nM None
Plasmodium falciparum Plasmodium falciparum Potency 8492.1 nM None
Rattus norvegicus Aorta Inhibition -12.0 % 10.1016/j.ejmech.2015.08.027
Rattus norvegicus Aorta Inhibition -2.0 % 10.1016/j.ejmech.2015.08.027
Rattus norvegicus Aorta Inhibition 72.0 % 10.1016/j.ejmech.2015.08.027
Rattus norvegicus Aorta Inhibition 100.0 % 10.1016/j.ejmech.2015.08.027
Rattus norvegicus Peripheral myelin protein 22 Potency 18105.6 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 2667.9 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 26679.5 nM None
Rattus norvegicus Thoracic aorta Activity 10.0 % 10.1016/j.bmcl.2016.02.033
Rattus norvegicus Thoracic aorta Activity 61.0 % 10.1016/j.bmcl.2016.02.033
Saccharomyces cerevisiae Saccharomyces cerevisiae Potency 16360.1 nM None
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 10.26 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 15.04 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.52 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 2.15 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 6.25 % 10.21203/rs.3.rs-23951/v1
Sus scrofa Tubulin IC50 40000.0 nM 10.1016/j.bmcl.2005.09.001
Trypanosoma cruzi Cruzipain Potency 19952.6 nM None
None ADMET CL 14.0 mL.min-1.kg-1 10.1124/dmd.105.006619
None ADMET CL 25.7 mL.min-1.kg-1 10.1124/dmd.105.006619
None ADMET CL 45.0 mL.min-1.kg-1 10.1124/dmd.105.006619
None ADMET CL 52.0 mL.min-1.kg-1 10.1124/dmd.105.006619
None ADMET LD50 50.0 uM 10.1021/jm0204183
None ADMET Vdss 0.98 L.kg-1 10.1124/dmd.105.006619
None ADMET Vdss 1.4 L.kg-1 10.1124/dmd.105.006619
None ADMET Vdss 1.45 L.kg-1 10.1124/dmd.105.006619
None ADMET Vdss 1.6 mL/min/kg 10.1124/dmd.105.006619
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None NON-PROTEIN TARGET IC50 30.0 nM 10.1016/j.bmc.2009.08.044
None NON-PROTEIN TARGET IC50 40.0 nM 10.1016/j.bmc.2010.05.049
None NON-PROTEIN TARGET IC50 40.0 nM 10.1016/j.bmc.2012.05.068
None NON-PROTEIN TARGET IC50 6000.0 nM 10.1016/j.bmc.2010.01.011
None NON-PROTEIN TARGET IC50 8300.0 nM 10.1016/j.ejmech.2012.10.001
None NON-PROTEIN TARGET IC50 15000.0 nM 10.1016/j.ejmech.2012.10.001
None NON-PROTEIN TARGET IC50 50000.0 nM 10.1016/j.bmc.2010.01.011
None NON-PROTEIN TARGET IC50 60000.0 nM 10.1016/j.bmc.2015.03.061
None NON-PROTEIN TARGET Inhibition 54.0 % 10.1016/j.bmc.2010.04.076
None NON-PROTEIN TARGET Inhibition nan % 10.1016/j.ejmech.2012.10.001
None NON-PROTEIN TARGET Potency 5623.4 nM None
None NON-PROTEIN TARGET Potency 7943.3 nM None
None NON-PROTEIN TARGET Potency 14125.4 nM None
None No relevant target Solubility 1.0 ug.mL-1 10.1021/jm0204183
None Unchecked AbsAC35_uM 3.24 uM None
None Unchecked AC50 10840.0 nM None
None Unchecked EC50 110000.0 nM None
None Unchecked IC50 800.0 nM 10.1016/j.bmc.2009.09.038
None Unchecked IC50 1040.0 nM 10.1021/jm0204183
None Unchecked IC50 nan None 10.1016/j.bmc.2016.11.026
None Unchecked Inhibition 65.0 % 10.1021/jm020899q
None Unchecked Inhibition nan % 10.1016/j.bmc.2016.11.026
None Unchecked Inhibition nan % 10.1038/nchembio873
None Unchecked Inhibition nan % 10.1039/C4MD00211C
None Unchecked Potency 3162.3 nM None
None Unchecked Potency 3981.1 nM None
None Unchecked Potency 7307.8 nM None
None Unchecked Potency 28183.8 nM None
None Unchecked Potency 35481.3 nM None

Metabolism Information