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name Structure Reference Source Properties Activities Metabolism

None

AlkaPlorer ID: AK324432

Synonym: None

IUPAC Name: 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide

Structure

SMILES: NC(=O)C1=CC=C(C2=NC(C3=CC=CC=N3)=C(C3=CC=C4OCOC4=C3)N2)C=C1

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InChI: InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)

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InChIKey: FHYUGAJXYORMHI-UHFFFAOYSA-N

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Reference

PubChem CID: 4521392

CAS: 301836-41-9

NPASS: NPC487448

Source

Species Genus Family Order Class Phylum Kingdom Domain
Penicillium sp. sh18 Penicillium Aspergillaceae Eurotiales Eurotiomycetes Ascomycota Fungi Eukaryota

Properties Information

Molecule Weight: 384.39500000000015

TPSA？: 103.12

MolLogP？: 3.633300000000001

Number of H-Donors: 2

Number of H-Acceptors: 5

RingCount: 5

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus anthracis Anthrax lethal factor Potency 15848.9 nM None
Gallus gallus Myosin light chain kinase, smooth muscle Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 35481.3 nM None
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Activin receptor type-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Activin receptor type-1 Ki 3981.07 nM None
Homo sapiens Activin receptor type-1B Inhibition 25.7 % 10.1016/j.bmcl.2009.04.066
Homo sapiens Activin receptor type-1B Inhibition 69.4 % 10.1016/j.bmcl.2009.04.066
Homo sapiens Activin receptor type-1B Inhibition 99.0 % 10.1021/jm301144g
Homo sapiens Activin receptor type-1B Kd 190.0 nM 10.1038/nbt1358
Homo sapiens Activin receptor type-1C Inhibition 8.9 % 10.1016/j.bmcl.2009.04.066
Homo sapiens Activin receptor type-1C Inhibition 54.0 % 10.1016/j.bmcl.2009.04.066
Homo sapiens Activin receptor type-1C Inhibition 99.0 % 10.1021/jm301144g
Homo sapiens Activin receptor type-2A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Activin receptor type-2B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Adaptor-associated kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 23755.8 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 31622.8 nM None
Homo sapiens ALK tyrosine kinase receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens ALK tyrosine kinase receptor Ki 6309.57 nM None
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Ki 3162.28 nM None
Homo sapiens AMP-activated protein kinase, alpha-2 subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ankyrin repeat and protein kinase domain-containing protein 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Arachidonate 15-lipoxygenase, type II Potency 1258.9 nM None
Homo sapiens BMP-2-inducible protein kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Bone morphogenetic protein receptor type-1A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Bone morphogenetic protein receptor type-2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens BR serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens BR serine/threonine-protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens C32 Activity nan None 10.1128/aac.00022-07
Homo sapiens CaM kinase I alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase I delta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase I delta Ki 2511.89 nM None
Homo sapiens CaM kinase I gamma Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase II alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase II alpha Ki 7943.28 nM None
Homo sapiens CaM kinase II beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase II delta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase II gamma Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase IV Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM-kinase kinase alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM-kinase kinase beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Ki 1258.93 nM None
Homo sapiens cAMP-dependent protein kinase beta-1 catalytic subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I alpha Ki 100.0 nM None
Homo sapiens Casein kinase I delta Kd 170.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I epsilon Kd 260.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I gamma 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I gamma 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase II alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase II alpha (prime) Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I isoform alpha-like Kd 5900.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I isoform gamma-3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cell division cycle 2-like protein kinase 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cell division protein kinase 8 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cell division protein kinase 8 Ki 3981.07 nM None
Homo sapiens cGMP-dependent protein kinase 1 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens cGMP-dependent protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Chaperone activity of bc1 complex-like, mitochondrial Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Citron Rho-interacting kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens c-Jun N-terminal kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens c-Jun N-terminal kinase 1 Ki 5011.87 nM None
Homo sapiens c-Jun N-terminal kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens c-Jun N-terminal kinase 2 Ki 3981.07 nM None
Homo sapiens c-Jun N-terminal kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens c-Jun N-terminal kinase 3 Ki 3162.28 nM None
Homo sapiens Cyclin-dependent kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 7 Ki 3981.07 nM None
Homo sapiens Cyclin-dependent kinase 9 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 9 Ki 1584.89 nM None
Homo sapiens Cytochrome P450 1A2 AC50 15848.93 nM None
Homo sapiens Cytochrome P450 2C19 AC50 2511.89 nM None
Homo sapiens Cytochrome P450 2C19 Potency 2511.9 nM None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2D6 AC50 12589.25 nM None
Homo sapiens Cytochrome P450 2D6 Potency 12589.3 nM None
Homo sapiens Cytochrome P450 3A4 AC50 10000.0 nM None
Homo sapiens Cytochrome P450 3A4 Potency 10000.0 nM None
Homo sapiens Death-associated protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Death-associated protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Death-associated protein kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Death-associated protein kinase 3 Ki 5011.87 nM None
Homo sapiens Discoidin domain-containing receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Ki 3162.28 nM None
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Ki 3981.07 nM None
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity protein kinase CLK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity protein kinase CLK2 Ki 3981.07 nM None
Homo sapiens Dual specificity protein kinase CLK3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity protein kinase CLK4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity protein kinase CLK4 Ki 2511.89 nM None
Homo sapiens Dual specificity protein kinase TTK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity testis-specific protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Ki 1995.26 nM None
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Ki 2511.89 nM None
Homo sapiens Dual specificty protein kinase CLK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 31622.8 nM None
Homo sapiens Ephrin type-A receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 8 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-B receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-B receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-B receptor 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-B receptor 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Epidermal growth factor receptor erbB1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Epithelial discoidin domain-containing receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Eukaryotic translation initiation factor 2-alpha kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Fibroblast growth factor receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Fibroblast growth factor receptor 1 Ki 3981.07 nM None
Homo sapiens Fibroblast growth factor receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Fibroblast growth factor receptor 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Fibroblast growth factor receptor 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Focal adhesion kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Focal adhesion kinase 1 Ki 6309.57 nM None
Homo sapiens Glycogen synthase kinase-3 alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Glycogen synthase kinase-3 alpha Ki 3981.07 nM None
Homo sapiens Glycogen synthase kinase-3 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Glycogen synthase kinase-3 beta Ki 3981.07 nM None
Homo sapiens G protein-coupled receptor kinase 5 Ki 3981.07 nM None
Homo sapiens Growth/differentiation factor 8 Inhibition nan % 10.1021/jm501170d
Homo sapiens HEK293 Potency 6284.1 nM None
Homo sapiens Hepatocyte growth factor receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Hepatocyte growth factor receptor Ki 2511.89 nM None
Homo sapiens Histone acetyltransferase GCN5 Potency 25118.9 nM None
Homo sapiens Histone deacetylase 6 Inhibition 4.32 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 31.78 % 10.6019/CHEMBL4808148
Homo sapiens Inhibitor of nuclear factor kappa B kinase epsilon subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Inhibitor of nuclear factor kappa B kinase epsilon subunit Ki 3162.28 nM None
Homo sapiens Insulin-like growth factor I receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Insulin-like growth factor I receptor Ki 2511.89 nM None
Homo sapiens Insulin receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Insulin receptor-related protein Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Interferon-induced, double-stranded RNA-activated protein kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Interleukin-1 receptor-associated kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Leucine-rich repeat serine/threonine-protein kinase 2 Ki 2511.89 nM None
Homo sapiens Leukocyte tyrosine kinase receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Leukocyte tyrosine kinase receptor Ki 2511.89 nM None
Homo sapiens LIM domain kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens LIM domain kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Lysine-specific demethylase 4D-like Potency 19952.6 nM None
Homo sapiens Macrophage colony stimulating factor receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Macrophage colony stimulating factor receptor Ki 2511.89 nM None
Homo sapiens Macrophage-stimulating protein receptor Ki 3981.07 nM None
Homo sapiens MAP kinase-activated protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase-activated protein kinase 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase ERK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase ERK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase ERK2 Potency 39810.7 nM None
Homo sapiens MAP kinase-interacting serine/threonine-protein kinase MNK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase p38 NA nan None 10.1021/jm010493y
Homo sapiens MAP kinase p38 alpha Activity 49.0 % 10.1016/j.ejmech.2008.03.024
Homo sapiens MAP kinase p38 alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase p38 alpha Ki 3981.07 nM None
Homo sapiens MAP kinase p38 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase p38 gamma Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase signal-integrating kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP/microtubule affinity-regulating kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Maternal embryonic leucine zipper kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Microtubule-associated protein tau Potency 15848.9 nM None
Homo sapiens Microtubule-associated protein tau Potency 22387.2 nM None
Homo sapiens Mitogen-activated protein kinase 15 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase 7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 10 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 11 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Ki 5011.87 nM None
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mixed lineage kinase 7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mothers against decapentaplegic homolog 2/homolog 3 Inhibition nan % 10.1021/acs.jnatprod.5b00814
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myosin IIIA Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myosin-IIIB Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens myosin light chain kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myosin light chain kinase family member 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myosin light chain kinase, smooth muscle Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myotonin-protein kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Nerve growth factor receptor Trk-A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Nerve growth factor receptor Trk-A Ki 3162.28 nM None
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Ki 3981.07 nM None
Homo sapiens Non-receptor tyrosine-protein kinase TNK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens NT-3 growth factor receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens NT-3 growth factor receptor Ki 3162.28 nM None
Homo sapiens NUAK family SNF1-like kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens NUAK family SNF1-like kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Phosphorylase kinase gamma subunit 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Phosphorylase kinase gamma subunit 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens PI3-kinase p110-alpha subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens PITSLRE serine/threonine-protein kinase CDC2L1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens PITSLRE serine/threonine-protein kinase CDC2L2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Platelet-derived growth factor receptor alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Platelet-derived growth factor receptor alpha Ki 2511.89 nM None
Homo sapiens Platelet-derived growth factor receptor beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C delta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C epsilon Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C eta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C mu Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C nu Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C nu Ki 3981.07 nM None
Homo sapiens Protein kinase C theta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C theta Ki 2511.89 nM None
Homo sapiens Protein kinase N1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase N2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein tyrosine kinase 2 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Receptor-interacting serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Rho-associated protein kinase 1 Ki 3981.07 nM None
Homo sapiens Rho-associated protein kinase 2 Ki 3981.07 nM None
Homo sapiens Ribosomal protein S6 kinase alpha 1 Kd 1300.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 3 Ki 3981.07 nM None
Homo sapiens Ribosomal protein S6 kinase alpha 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 10 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 11 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 16 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 17A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 17B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 24 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 25 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 32B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 32C Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 33 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 36 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 38-like Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase AKT Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase AKT2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase AKT3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Aurora-A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Aurora-A Ki 1584.89 nM None
Homo sapiens Serine/threonine-protein kinase Aurora-B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Aurora-C Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase B-raf Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Chk1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase c-TAK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase c-TAK1 Ki 5011.87 nM None
Homo sapiens Serine/threonine-protein kinase D2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase DCLK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase DCLK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase DCLK3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase GAK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase LATS1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase LATS2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MARK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MRCK-A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MRCK beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MRCK gamma Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MST1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MST2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MST4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Nek1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase NEK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Nek5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase NEK6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase NEK7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase NEK9 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine protein kinase NLK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK 4 Ki 5011.87 nM None
Homo sapiens Serine/threonine-protein kinase PAK6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PCTAIRE-2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PCTAIRE-3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PFTAIRE-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PIM1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PIM1 Ki 6309.57 nM None
Homo sapiens Serine/threonine-protein kinase PIM2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PIM3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PLK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PLK3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PLK4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PRKX Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PRKX Ki 3162.28 nM None
Homo sapiens Serine/threonine-protein kinase RAF Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase receptor R3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase RIO1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase RIO3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase RIPK2 Kd 3400.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase SIK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase SIK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase SRPK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase SRPK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase TAO1 Ki 2511.89 nM None
Homo sapiens Serine/threonine-protein kinase TBK1 Ki 3162.28 nM None
Homo sapiens Serine/threonine-protein kinase TNNI3K Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase tousled-like 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase WEE1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Stem cell growth factor receptor Kd 10000.0 nM 10.1016/j.ejmech.2011.02.057
Homo sapiens Stem cell growth factor receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Stem cell growth factor receptor Ki 6309.57 nM None
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens TGF-beta receptor type I Activity 18.0 % 10.1016/j.bmcl.2008.01.084
Homo sapiens TGF-beta receptor type I Activity 25.0 % 10.1016/j.ejmech.2008.03.024
Homo sapiens TGF-beta receptor type I Activity 51.0 % 10.1016/j.bmcl.2008.01.084
Homo sapiens TGF-beta receptor type I Activity 68.0 % 10.1021/jm070129k
Homo sapiens TGF-beta receptor type I Activity 69.0 % 10.1021/jm070129k
Homo sapiens TGF-beta receptor type I Activity 75.0 % 10.1016/j.bmcl.2008.01.084
Homo sapiens TGF-beta receptor type I Activity 76.0 % 10.1016/j.ejmech.2008.03.024
Homo sapiens TGF-beta receptor type I Activity 128.0 % 10.1021/jm070129k
Homo sapiens TGF-beta receptor type I Activity nan None 10.1021/jm070129k
Homo sapiens TGF-beta receptor type I EC50 172.0 nM 10.1021/jm100812a
Homo sapiens TGF-beta receptor type I IC50 66.0 nM 10.1021/jm301144g
Homo sapiens TGF-beta receptor type I IC50 67.1 nM 10.1021/acs.jmedchem.9b00708
Homo sapiens TGF-beta receptor type I IC50 70.0 nM 10.1016/j.ejmech.2018.11.072
Homo sapiens TGF-beta receptor type I IC50 94.0 nM 10.1016/j.bmcl.2009.04.066
Homo sapiens TGF-beta receptor type I IC50 94.0 nM 10.1016/j.bmcl.2010.01.140
Homo sapiens TGF-beta receptor type I IC50 94.0 nM 10.1016/j.ejmech.2009.07.008
Homo sapiens TGF-beta receptor type I IC50 94.0 nM 10.1016/j.ejmech.2020.112154
Homo sapiens TGF-beta receptor type I IC50 94.0 nM 10.1021/jm010493y
Homo sapiens TGF-beta receptor type I IC50 125.0 nM 10.1021/jm100812a
Homo sapiens TGF-beta receptor type I IC50 250.0 nM 10.1016/j.bmcl.2009.10.108
Homo sapiens TGF-beta receptor type I IC50 350.0 nM 10.1016/j.bmcl.2013.08.105
Homo sapiens TGF-beta receptor type I IC50 1542.0 nM 10.1021/jm070129k
Homo sapiens TGF-beta receptor type I Inhibition 7.54 % 10.1016/j.bmcl.2013.08.105
Homo sapiens TGF-beta receptor type I Inhibition 8.17 % 10.1016/j.bmcl.2013.08.105
Homo sapiens TGF-beta receptor type I Inhibition 8.51 % 10.1016/j.bmcl.2013.08.105
Homo sapiens TGF-beta receptor type I Inhibition 14.58 % 10.1016/j.bmcl.2013.08.105
Homo sapiens TGF-beta receptor type I Inhibition 14.6 % 10.1016/j.bmcl.2009.04.066
Homo sapiens TGF-beta receptor type I Inhibition 15.8 % 10.1016/j.bmcl.2013.08.105
Homo sapiens TGF-beta receptor type I Inhibition 24.2 % 10.1016/j.bmcl.2009.04.066
Homo sapiens TGF-beta receptor type I Inhibition 39.82 % 10.1016/j.bmcl.2013.08.105
Homo sapiens TGF-beta receptor type I Inhibition 75.1 % 10.1016/j.bmcl.2009.04.066
Homo sapiens TGF-beta receptor type I Inhibition 84.75 % 10.1016/j.bmcl.2013.08.105
Homo sapiens TGF-beta receptor type I Inhibition 96.52 % 10.1016/j.bmcl.2013.08.105
Homo sapiens TGF-beta receptor type I Inhibition 99.0 % 10.1021/jm301144g
Homo sapiens TGF-beta receptor type I Kd 170.0 nM 10.1038/nbt1358
Homo sapiens TGF-beta receptor type I Ki 17.0 nM 10.1016/j.bmcl.2009.10.108
Homo sapiens TGF-beta receptor type I logKi -1.027 None 10.1016/j.bmcl.2010.01.140
Homo sapiens TGF-beta receptor type I Selectivity 0.0104 None 10.1038/nbt1358
Homo sapiens TGF-beta receptor type II IC50 66.0 nM 10.1021/jm301144g
Homo sapiens TGF-beta receptor type II Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens TRAF2- and NCK-interacting kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine- and threonine-specific cdc2-inhibitory kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine kinase non-receptor protein 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine kinase non-receptor protein 2 Ki 3981.07 nM None
Homo sapiens Tyrosine-protein kinase ABL Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ABL2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase BLK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase BMX Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase BRK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase BTK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase BTK Ki 6309.57 nM None
Homo sapiens Tyrosine-protein kinase CSK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FER Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FES Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FGR Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FRK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FYN Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FYN Ki 6309.57 nM None
Homo sapiens Tyrosine-protein kinase HCK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ITK/TSK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase JAK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase JAK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase JAK2 Ki 2511.89 nM None
Homo sapiens Tyrosine-protein kinase JAK3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase JAK3 Ki 5011.87 nM None
Homo sapiens Tyrosine-protein kinase LCK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase LCK Ki 6309.57 nM None
Homo sapiens Tyrosine-protein kinase Lyn Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor FLT3 Ki 3162.28 nM None
Homo sapiens Tyrosine-protein kinase receptor RET Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor RET Ki 3162.28 nM None
Homo sapiens Tyrosine-protein kinase receptor Tie-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Ki 3162.28 nM None
Homo sapiens Tyrosine-protein kinase receptor UFO Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase SRC Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase Srms Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase SYK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase TEC Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase TIE-2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase TXK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase TYK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase YES Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase YES Potency 58245.8 nM None
Homo sapiens Tyrosine-protein kinase ZAP-70 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 14125.4 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 17782.8 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 18837.5 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 21136.0 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 56234.1 nM None
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Potency 56234.1 nM None
Homo sapiens Uncharacterized aarF domain-containing protein kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Vascular endothelial growth factor receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Vascular endothelial growth factor receptor 1 Ki 3981.07 nM None
Homo sapiens Vascular endothelial growth factor receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Vascular endothelial growth factor receptor 2 Ki 2511.89 nM None
Homo sapiens Vascular endothelial growth factor receptor 3 Kd 10000.0 nM 10.1038/nbt1358
Mus musculus Transforming growth factor beta-1 proprotein/Mothers against decapentaplegic homolog 3 Activity 98.9 % 10.1016/j.ejmech.2022.114643
Photinus pyralis Luciferin 4-monooxygenase Potency 7943.3 nM None
Rattus norvegicus Inositol monophosphatase 1 Potency 2511.9 nM None
Rattus norvegicus Mothers against decapentaplegic homolog 2/homolog 3 Inhibition nan % 10.1021/acs.jnatprod.5b00814
Rattus norvegicus NRK-52E Activity nan None 10.1016/j.bmcl.2017.07.001
Rattus norvegicus TGF-beta receptor type-1 Inhibition nan % 10.1021/acs.jmedchem.9b00708
Rattus norvegicus Tubulin alpha-1 chain Kd 10000.0 nM 10.1038/nbt1358
Schistosoma mansoni Schistosoma mansoni In vitro activity nan None 10.6019/CHEMBL5096127
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition -11.0 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 8.475 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -5.77 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.42 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.54 % 10.6019/CHEMBL4495565
Trypanosoma cruzi Trypanosoma cruzi Activity 1.4 None 10.1128/aac.00022-07
Trypanosoma cruzi Trypanosoma cruzi Activity 4.4 None 10.1128/aac.00022-07
Trypanosoma cruzi Trypanosoma cruzi Activity 19.0 None 10.1128/aac.00022-07
Trypanosoma cruzi Trypanosoma cruzi Activity 26.5 % 10.1128/aac.00022-07
Trypanosoma cruzi Trypanosoma cruzi Activity 38.0 None 10.1128/aac.00022-07
Trypanosoma cruzi Trypanosoma cruzi Activity 47.9 % 10.1128/aac.00022-07
Trypanosoma cruzi Trypanosoma cruzi Activity 53.0 None 10.1128/aac.00022-07
Trypanosoma cruzi Trypanosoma cruzi Activity 58.0 None 10.1128/aac.00022-07
Trypanosoma cruzi Trypanosoma cruzi Activity nan None 10.1128/aac.00022-07
Trypanosoma cruzi Trypanosoma cruzi Inhibition 2.8 % 10.1128/aac.00022-07
Trypanosoma cruzi Trypanosoma cruzi Inhibition 39.0 % 10.1128/aac.00022-07
None NON-PROTEIN TARGET Activity 55.0 % 10.1016/j.bmcl.2009.04.066
None NON-PROTEIN TARGET IC50 500.0 nM 10.1021/jm401117t
None NON-PROTEIN TARGET Potency 1.1 nM None
None NON-PROTEIN TARGET Potency 6.0 nM None
None NON-PROTEIN TARGET Potency 6678.0 nM None
None NON-PROTEIN TARGET Potency 11875.4 nM None
None NON-PROTEIN TARGET Potency 16774.4 nM None
None NON-PROTEIN TARGET Potency 18821.2 nM None
None Unchecked Activity nan None 10.1021/acs.jmedchem.1c01800
None Unchecked Activity nan None 10.1021/acs.jnatprod.5b00814
None Unchecked Activity nan None 10.1128/aac.00022-07
None Unchecked Inhibition nan % 10.1021/acs.jnatprod.5b00814
None Unchecked Inhibition nan % None
None Unchecked Potency 13.2 nM None
None Unchecked Potency 37.2 nM None
None Unchecked Potency 112.2 nM None
None Unchecked Potency 1865.5 nM None
None Unchecked Potency 6284.1 nM None
None Unchecked Potency 8332.8 nM None
None Unchecked Potency 14125.4 nM None
None Unchecked Potency 16626.1 nM None
None Unchecked Potency 19952.6 nM None
None Unchecked Potency 33173.4 nM None
None Unchecked Potency 35481.3 nM None
None Unchecked Potency 37221.2 nM None
None Unchecked Potency 46858.7 nM None

Metabolism Information