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name Structure Reference Source Properties Activities Metabolism

None

AlkaPlorer ID: AK324595

Synonym: None

IUPAC Name: (4S,7R,13S)-13-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid

Structure

SMILES: CC1(C)SSC(C)(C)[C@@H](N=C(O)[C@@H](N)CC2=CC=C(O)C=C2)C(O)=NCC(O)=N[C@H](CC2=CC=CC=C2)C(O)=N[C@H]1C(=O)O

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InChI: InChI=1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21+,23-,24-/m0/s1

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InChIKey: MCMMCRYPQBNCPH-DVKRWUGUSA-N

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Reference

PubChem CID: 44299404

NPASS: NPC488040

Source

Species Genus Family Order Class Phylum Kingdom Domain
Stephania japonica Stephania Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 645.8040000000003

TPSA？: 213.91

MolLogP？: 4.473300000000002

Number of H-Donors: 7

Number of H-Acceptors: 9

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bos taurus Mu opioid receptor Ki 82.0 nM 10.1021/jm00087a004
Bos taurus Mu opioid receptor Ki 460.0 nM 10.1021/jm00087a004
Cavia porcellus Cavia porcellus EC50 nan nM 10.1016/0960-894X(95)00325-N
Cavia porcellus Cavia porcellus E max 90.0 % 10.1021/jm00110a010
Cavia porcellus Cavia porcellus IC50 10000.0 nM 10.1021/jm00118a005
Cavia porcellus Cavia porcellus IC50 11600.0 nM 10.1021/jm00163a041
Cavia porcellus Cavia porcellus IC50 16240.0 nM 10.1021/jm00123a023
Cavia porcellus Cavia porcellus Ratio 2000.0 None 10.1021/jm00163a041
Cavia porcellus Cholecystokinin A receptor IC50 nan nM 10.1021/jm960078j
Cavia porcellus Kappa opioid receptor IC50 2.1 nM 10.1021/jm00051a003
Cavia porcellus Kappa opioid receptor IC50 1000.0 nM 10.1021/jm00003a020
Cavia porcellus Kappa opioid receptor IC50 1000.0 nM 10.1021/jm00044a006
Cavia porcellus Kappa opioid receptor Ki 350.0 nM 10.1021/jm00087a004
Cavia porcellus Kappa opioid receptor Ki 5000.0 nM 10.1016/j.bmc.2010.06.005
Cavia porcellus Kappa opioid receptor Ki 10000.0 nM 10.1016/j.bmcl.2012.01.063
Cavia porcellus Kappa opioid receptor Ki 10000.0 nM 10.1021/jm00087a006
Cavia porcellus Kappa opioid receptor Ki 10000.0 nM 10.1021/jm00101a030
Cavia porcellus Mu opioid receptor EC50 7300.0 nM 10.1021/jm00038a004
Cavia porcellus Mu opioid receptor EC50 7300.0 nM 10.1021/jm0303103
Cavia porcellus Mu opioid receptor Emax 51.4 nM 10.1016/s0960-894x(99)00613-7
Cavia porcellus Mu opioid receptor Emax 51.4 None 10.1016/s0960-894x(99)00525-9
Cavia porcellus Mu opioid receptor IC50 1000.0 nM 10.1021/jm00003a020
Cavia porcellus Mu opioid receptor IC50 1000.0 nM 10.1021/jm00044a006
Cavia porcellus Mu opioid receptor IC50 1760.0 nM 10.1021/jm00051a003
Cavia porcellus Mu opioid receptor IC50 2720.0 nM 10.1021/jm100157m
Cavia porcellus Mu opioid receptor IC50 2720.0 nM 10.1021/jm900473p
Cavia porcellus Mu opioid receptor IC50 5500.0 nM 10.1021/jm00109a019
Cavia porcellus Mu opioid receptor IC50 7300.0 nM 10.1021/jm00009a013
Cavia porcellus Mu opioid receptor IC50 7300.0 nM 10.1021/jm00027a018
Cavia porcellus Mu opioid receptor IC50 7300.0 nM 10.1021/jm00037a007
Cavia porcellus Mu opioid receptor IC50 7300.0 nM 10.1021/jm00040a002
Cavia porcellus Mu opioid receptor IC50 7300.0 nM 10.1021/jm00110a010
Cavia porcellus Mu opioid receptor IC50 7300.0 nM 10.1021/jm020108k
Cavia porcellus Mu opioid receptor IC50 7300.0 nM 10.1021/jm950695s
Cavia porcellus Mu opioid receptor IC50 7300.0 nM 10.1021/jm960078j
Cavia porcellus Mu opioid receptor IC50 7300.0 nM 10.1021/jm960319n
Cavia porcellus Mu opioid receptor IC50 10000.0 nM 10.1021/jm00397a019
Cavia porcellus Mu opioid receptor IC50 11600.0 nM 10.1021/jm030311v
Cavia porcellus Mu opioid receptor Kd 577.0 nM 10.1016/s0960-894x(99)00525-9
Cavia porcellus Mu opioid receptor Kd 577.0 nM 10.1016/s0960-894x(99)00613-7
Cavia porcellus Mu opioid receptor Ke nan None 10.1021/jm030311v
Cavia porcellus Mu opioid receptor Ki 810.0 nM 10.1021/jm00087a006
Cavia porcellus Mu opioid receptor Ki 810.0 nM 10.1021/jm00101a030
Cavia porcellus Mu opioid receptor Ratio 1800.0 None 10.1021/jm00037a007
Homo sapiens Cholecystokinin B receptor IC50 nan nM 10.1021/jm960078j
Homo sapiens Cytochrome P450 3A4 IC50 50000.0 nM 10.1021/jm021012t
Homo sapiens Delta opioid receptor Activity nan None 10.1021/jm400195y
Homo sapiens Delta opioid receptor Activity nan None 10.1021/np300653d
Homo sapiens Delta opioid receptor EC50 0.14 nM 10.1021/jm200894e
Homo sapiens Delta opioid receptor EC50 0.557 nM 10.1021/jm400195y
Homo sapiens Delta opioid receptor EC50 0.8 nM 10.1016/j.ejmech.2014.12.049
Homo sapiens Delta opioid receptor EC50 1.3 nM 10.1021/jm021073r
Homo sapiens Delta opioid receptor EC50 1.585 nM 10.1021/jm050851n
Homo sapiens Delta opioid receptor EC50 1.585 nM 10.1021/jm050921q
Homo sapiens Delta opioid receptor EC50 1.585 nM 10.1021/jm061369n
Homo sapiens Delta opioid receptor EC50 1.585 nM 10.1021/jm100982d
Homo sapiens Delta opioid receptor EC50 1.585 nM 10.1021/jm800389v
Homo sapiens Delta opioid receptor EC50 1.585 nM 10.1021/jm900473p
Homo sapiens Delta opioid receptor EC50 1.6 nM 10.1021/jm050851n
Homo sapiens Delta opioid receptor EC50 1.6 nM 10.1021/jm050921q
Homo sapiens Delta opioid receptor EC50 1.6 nM 10.1021/jm061369n
Homo sapiens Delta opioid receptor EC50 1.6 nM 10.1021/jm070332f
Homo sapiens Delta opioid receptor EC50 1.6 nM 10.1021/jm100982d
Homo sapiens Delta opioid receptor EC50 1.6 nM 10.1021/jm800389v
Homo sapiens Delta opioid receptor EC50 1.6 nM 10.1021/jm900473p
Homo sapiens Delta opioid receptor EC50 2.951 nM 10.1021/jm900604g
Homo sapiens Delta opioid receptor EC50 6.34 nM 10.1021/np300653d
Homo sapiens Delta opioid receptor EC50 9.29 nM 10.1016/j.bmcl.2014.08.012
Homo sapiens Delta opioid receptor EC50 15.0 nM 10.1016/j.bmc.2009.07.069
Homo sapiens Delta opioid receptor EC50 15.85 nM 10.1021/acsmedchemlett.5b00056
Homo sapiens Delta opioid receptor EC50 16.0 nM 10.1021/jm701440h
Homo sapiens Delta opioid receptor ED50 6.81 nM 10.1016/j.bmcl.2012.01.063
Homo sapiens Delta opioid receptor Emax 69.0 % 10.1021/jm050851n
Homo sapiens Delta opioid receptor Emax 69.0 % 10.1021/jm050921q
Homo sapiens Delta opioid receptor Emax 69.0 % 10.1021/jm061369n
Homo sapiens Delta opioid receptor Emax 69.0 % 10.1021/jm070332f
Homo sapiens Delta opioid receptor Emax 69.0 % 10.1021/jm100982d
Homo sapiens Delta opioid receptor Emax 69.0 % 10.1021/jm200894e
Homo sapiens Delta opioid receptor Emax 69.0 % 10.1021/jm800389v
Homo sapiens Delta opioid receptor Emax 69.0 % 10.1021/jm900473p
Homo sapiens Delta opioid receptor Emax 76.0 % 10.1016/j.bmc.2009.07.069
Homo sapiens Delta opioid receptor Emax 87.4 % 10.1021/jm400195y
Homo sapiens Delta opioid receptor Emax 90.0 % 10.1021/jm00091a006
Homo sapiens Delta opioid receptor Emax 169.0 % 10.1021/jm900604g
Homo sapiens Delta opioid receptor Emax 2200.0 % 10.1021/np300653d
Homo sapiens Delta opioid receptor IC50 0.14 nM 10.1016/j.bmc.2010.06.005
Homo sapiens Delta opioid receptor IC50 0.9 nM 10.1016/j.bmc.2014.07.012
Homo sapiens Delta opioid receptor IC50 1.12 nM 10.1021/np060179c
Homo sapiens Delta opioid receptor IC50 1.12 nM 10.1021/np060607e
Homo sapiens Delta opioid receptor IC50 1.2 nM 10.1021/np060577f
Homo sapiens Delta opioid receptor IC50 1.2 nM 10.1021/np070516x
Homo sapiens Delta opioid receptor IC50 1.2 nM 10.1021/np100009j
Homo sapiens Delta opioid receptor IC50 1.8 nM 10.1021/jm00003a020
Homo sapiens Delta opioid receptor IC50 1.8 nM 10.1021/jm00044a006
Homo sapiens Delta opioid receptor IC50 3.5 nM 10.1021/jm0155897
Homo sapiens Delta opioid receptor IC50 4.1 nM 10.1021/jm960078j
Homo sapiens Delta opioid receptor IC50 10.0 nM 10.1021/jm701575k
Homo sapiens Delta opioid receptor IC50 5000.0 nM 10.1021/jm00051a003
Homo sapiens Delta opioid receptor IC50 7300.0 nM 10.1021/jm00091a006
Homo sapiens Delta opioid receptor Imax 69.0 % 10.1016/j.bmc.2010.06.005
Homo sapiens Delta opioid receptor Ki 0.5 nM 10.1021/jm100157m
Homo sapiens Delta opioid receptor Ki 1.24 nM 10.1021/jm2003238
Homo sapiens Delta opioid receptor Ki 1.39 nM 10.1016/j.bmcl.2011.05.008
Homo sapiens Delta opioid receptor Ki 1.41 nM 10.1016/j.ejmech.2014.12.016
Homo sapiens Delta opioid receptor Ki 1.6 nM 10.1021/jm900473p
Homo sapiens Delta opioid receptor Ki 1.7 nM 10.1021/jm021073r
Homo sapiens Delta opioid receptor Ki 1.77 nM 10.1016/j.bmcl.2011.05.008
Homo sapiens Delta opioid receptor Ki 2.2 nM 10.1021/jm020108k
Homo sapiens Delta opioid receptor Ki 2.2 nM 10.1021/jm970861r
Homo sapiens Delta opioid receptor Ki 2.9 nM 10.1021/jm00087a004
Homo sapiens Delta opioid receptor Ki 3.3 nM 10.1021/jm301213s
Homo sapiens Delta opioid receptor Ki 3.3 nM 10.1021/jm5002925
Homo sapiens Delta opioid receptor Ki 3.98 nM 10.1021/jm00087a006
Homo sapiens Delta opioid receptor Ki 3.98 nM 10.1021/jm00101a030
Homo sapiens Delta opioid receptor logEC50 -8.8 None 10.1021/jm070332f
Homo sapiens Delta opioid receptor Log IC50 nan None 10.1021/jm050921q
Homo sapiens Delta opioid receptor Selectivity ratio 3270.0 None 10.1021/jm00091a006
Homo sapiens Delta opioid receptor Stimulation 100.0 % 10.1021/jm021073r
Homo sapiens Kappa opioid receptor Activity nan None 10.1021/acsmedchemlett.5b00056
Homo sapiens Kappa opioid receptor EC50 10000.0 nM 10.1021/jm021073r
Homo sapiens Kappa opioid receptor Ki 350.0 nM 10.1021/jm00087a004
Homo sapiens Kappa opioid receptor Ki 10000.0 nM 10.1021/jm020108k
Homo sapiens Kappa opioid receptor Ki 10000.0 nM 10.1021/jm021073r
Homo sapiens Kappa opioid receptor Ki 10000.0 nM 10.1021/jm2003238
Homo sapiens Kappa opioid receptor Ki 10000.0 nM 10.1021/jm970861r
Homo sapiens Kappa opioid receptor Ratio 1.0 None 10.1021/jm00069a017
Homo sapiens Kappa opioid receptor Stimulation 10000.0 % 10.1021/jm021073r
Homo sapiens Mu opioid receptor Activity nan None 10.1021/acsmedchemlett.5b00056
Homo sapiens Mu opioid receptor EC50 10000.0 nM 10.1021/jm021073r
Homo sapiens Mu opioid receptor IC50 610.0 nM 10.1021/jm0303103
Homo sapiens Mu opioid receptor IC50 nan None 10.1016/j.bmc.2010.06.005
Homo sapiens Mu opioid receptor Imax nan None 10.1016/j.bmc.2010.06.005
Homo sapiens Mu opioid receptor Ki 504.0 nM 10.1021/jm021073r
Homo sapiens Mu opioid receptor Ki 504.0 nM 10.1021/jm2003238
Homo sapiens Mu opioid receptor Ki 10000.0 nM 10.1021/jm020108k
Homo sapiens Mu opioid receptor Ki 10000.0 nM 10.1021/jm970861r
Homo sapiens Mu opioid receptor Ki nan None 10.1016/j.ejmech.2014.12.016
Homo sapiens Mu opioid receptor Stimulation 10000.0 % 10.1021/jm021073r
Homo sapiens Nociceptin receptor Emax 0.0 % 10.1016/j.bmc.2009.07.069
Homo sapiens Nociceptin receptor Ki 10000.0 nM 10.1021/jm2003238
Homo sapiens Opioid receptors; delta & kappa Selectivity 5880.0 None 10.1021/jm021073r
Homo sapiens Opioid receptors; mu & delta IC50 2.5 nM 10.1021/jm00397a019
Homo sapiens Opioid receptors; mu & delta Ki ratio 4550.0 None 10.1021/jm020108k
Homo sapiens Opioid receptors; mu & delta Ratio 116.0 None 10.1021/jm00110a010
Homo sapiens Opioid receptors; mu & delta Ratio 117.0 None 10.1021/jm00123a023
Homo sapiens Opioid receptors; mu & delta Ratio 204.0 None 10.1021/jm00087a006
Homo sapiens Opioid receptors; mu & delta Ratio 370.0 None 10.1021/jm9704762
Homo sapiens Opioid receptors; mu & delta Ratio 1100.0 None 10.1021/jm9704762
Homo sapiens Opioid receptors; mu & delta Selectivity 0.00025 None 10.1021/jm00397a019
Homo sapiens Opioid receptors; mu & delta Selectivity 120.0 None 10.1021/jm00027a018
Homo sapiens Opioid receptors; mu & delta Selectivity 296.0 None 10.1021/jm021073r
Homo sapiens Opioid receptors; mu & delta Selectivity 1780.0 None 10.1021/jm00038a004
Homo sapiens Opioid receptors; mu & delta Selectivity 1800.0 None 10.1021/jm00009a013
Homo sapiens Opioid receptors; mu/kappa/delta IC50 140.0 nM 10.1021/jm00051a003
Homo sapiens Opioid receptors; mu/kappa/delta IC50 1000.0 nM 10.1021/jm00003a020
Homo sapiens P-glycoprotein 1 Activity 0.0 % 10.1021/jm021012t
Homo sapiens P-glycoprotein 1 Activity 4.0 nM/mg*min 10.1021/jm021012t
Homo sapiens P-glycoprotein 1 IC50 50000.0 nM 10.1021/jm021012t
Homo sapiens P-glycoprotein 1 Inhibition 0.0 % 10.1021/jm021012t
Homo sapiens Solute carrier organic anion transporter family member 1A2 Activity nan None None
Homo sapiens Solute carrier organic anion transporter family member 1A2 Km 202000.0 nM None
Homo sapiens Solute carrier organic anion transporter family member 1B1 Activity nan None 10.1053/gast.2001.21176
Homo sapiens Solute carrier organic anion transporter family member 1B1 Activity nan None 10.1211/0022357021440
Homo sapiens Solute carrier organic anion transporter family member 1B3 Activity nan None 10.1053/gast.2001.21176
Homo sapiens Solute carrier organic anion transporter family member 1B3 Activity nan None 10.1053/gast.2001.24804
Homo sapiens Solute carrier organic anion transporter family member 1C1 Activity nan None 10.1210/me.2001-0309
Mus musculus Delta opioid receptor EC50 2.05 nM 10.1016/j.ejmech.2013.09.031
Mus musculus Delta opioid receptor EC50 4.1 nM 10.1021/jm00038a004
Mus musculus Delta opioid receptor EC50 4.1 nM 10.1021/jm0303103
Mus musculus Delta opioid receptor IC50 1.6 nM 10.1021/jm00038a004
Mus musculus Delta opioid receptor IC50 2.02 nM 10.1016/j.bmcl.2012.01.063
Mus musculus Delta opioid receptor IC50 2.5 nM 10.1021/jm100157m
Mus musculus Delta opioid receptor IC50 2.5 nM 10.1021/jm900473p
Mus musculus Delta opioid receptor IC50 2.5 nM 10.1021/jm9704762
Mus musculus Delta opioid receptor IC50 2.65 nM 10.1021/jm00109a019
Mus musculus Delta opioid receptor IC50 4.1 nM 10.1021/jm00009a013
Mus musculus Delta opioid receptor IC50 4.1 nM 10.1021/jm00027a018
Mus musculus Delta opioid receptor IC50 4.1 nM 10.1021/jm00037a007
Mus musculus Delta opioid receptor IC50 4.1 nM 10.1021/jm00091a006
Mus musculus Delta opioid receptor IC50 4.1 nM 10.1021/jm00110a010
Mus musculus Delta opioid receptor IC50 4.1 nM 10.1021/jm020108k
Mus musculus Delta opioid receptor IC50 4.1 nM 10.1021/jm950695s
Mus musculus Delta opioid receptor IC50 5.1 nM 10.1021/jm00040a002
Mus musculus Delta opioid receptor IC50 5.1 nM 10.1021/jm960319n
Mus musculus Delta opioid receptor IC50 5.81 nM 10.1021/jm030311v
Mus musculus Delta opioid receptor IC50 609.0 nM 10.1021/jm00038a004
Mus musculus Delta opioid receptor Ke nan None 10.1021/jm030311v
Mus musculus Delta opioid receptor Ki 0.9 nM 10.1016/j.bmcl.2014.08.012
Mus musculus Delta opioid receptor Ratio 1.4 None 10.1021/jm00069a017
Mus musculus Delta opioid receptor Ratio 3.8 None 10.1021/jm00069a017
Mus musculus Delta opioid receptor Ratio 5.0 None 10.1021/jm00069a017
Mus musculus Kappa opioid receptor EC50 nan None 10.1016/j.ejmech.2013.09.031
Mus musculus Mu opioid receptor EC50 nan None 10.1016/j.ejmech.2013.09.031
Mus musculus Mu opioid receptor IC50 2700.0 nM 10.1021/jm9704762
Mus musculus Mu opioid receptor Ki 2.95 nM 10.1021/jm00046a026
Mus musculus Mu opioid receptor Ratio 1.4 None 10.1021/jm00069a017
Mus musculus Mus musculus Activity 5.0 % 10.1021/jm950817g
Mus musculus Mus musculus Activity 55.0 % 10.1021/jm950817g
Mus musculus Mus musculus Animals 0.0 % 10.1021/jm00087a004
Mus musculus Mus musculus EC50 2.8 nM 10.1016/0960-894X(95)00325-N
Mus musculus Mus musculus EC50 12.9 nM 10.1021/jm00082a008
Mus musculus Mus musculus ED50 0.9 nM 10.1021/jm00101a009
Mus musculus Mus musculus ED50 1.4 ug 10.1021/jm00082a008
Mus musculus Mus musculus ED50 4.0 nM 10.1021/jm00101a009
Mus musculus Mus musculus ED50 11.5 nM mouse-1 10.1021/jm00069a017
Mus musculus Mus musculus ED50 nan mg.kg-1 10.1021/jm00082a008
Mus musculus Mus musculus IC50 2.5 nM 10.1021/jm00118a005
Mus musculus Mus musculus IC50 4.11 nM 10.1016/s0960-894x(99)00085-2
Mus musculus Mus musculus IC50 4.3 nM 10.1021/jm00123a023
Mus musculus Mus musculus IC50 5.81 nM 10.1021/jm00163a041
Mus musculus Mus musculus Ke 0.021 nM 10.1016/s0960-894x(99)00085-2
Mus musculus Mus musculus Ke 20.4 nM 10.1016/0960-894X(95)00325-N
Mus musculus Opioid receptor IC50 2.8 nM 10.1021/jm00101a009
Mus musculus P-glycoprotein 1 IC50 50000.0 nM 10.1021/jm021012t
Mus musculus P-glycoprotein 3 Activity nan None 10.1016/s0304-3940(01)01640-8
Mus musculus P-glycoprotein 3 IC50 50000.0 nM 10.1021/jm021012t
Mus musculus P-glycoprotein 3 Ratio 0.6 None 10.1021/jm021012t
Mus musculus P-glycoprotein 3 Ratio 0.8 None 10.1021/jm021012t
Mus musculus P-glycoprotein 3 Ratio 0.9 None 10.1021/jm021012t
Rattus norvegicus Delta opioid receptor Activity 0.59 None 10.1021/jm0612463
Rattus norvegicus Delta opioid receptor Activity 487.0 nM 10.1021/jm0612463
Rattus norvegicus Delta opioid receptor IC50 0.63 nM 10.1016/s0960-894x(98)00349-7
Rattus norvegicus Delta opioid receptor IC50 1.6 nM 10.1021/jm00091a006
Rattus norvegicus Delta opioid receptor IC50 1.6 nM 10.1021/jm0303103
Rattus norvegicus Delta opioid receptor IC50 1.6 nM 10.1021/jm980374r
Rattus norvegicus Delta opioid receptor IC50 3.0 nM 10.1021/jm00123a023
Rattus norvegicus Delta opioid receptor IC50 4.0 nM 10.1016/s0960-894x(98)00349-7
Rattus norvegicus Delta opioid receptor IC50 5.25 nM 10.1021/jm00163a041
Rattus norvegicus Delta opioid receptor IC50 5.8 nM 10.1021/jm00027a018
Rattus norvegicus Delta opioid receptor IC50 5.8 nM 10.1021/jm00109a019
Rattus norvegicus Delta opioid receptor IC50 5.83 nM 10.1021/jm00091a006
Rattus norvegicus Delta opioid receptor IC50 5.83 nM 10.1021/jm00110a010
Rattus norvegicus Delta opioid receptor IC50 6.0 nM 10.1021/np50081a017
Rattus norvegicus Delta opioid receptor IC50 8.5 nM 10.1021/jm00037a007
Rattus norvegicus Delta opioid receptor IC50 10.0 nM 10.1021/jm9704762
Rattus norvegicus Delta opioid receptor Ki 2.72 nM 10.1016/j.bmc.2010.06.005
Rattus norvegicus Delta opioid receptor Ki 8.39 nM 10.1016/j.bmcl.2012.01.063
Rattus norvegicus Delta opioid receptor Ki 10.9 nM 10.1021/jm00118a005
Rattus norvegicus Delta opioid receptor Ki 10.9 nM 10.1021/jm00397a019
Rattus norvegicus Delta opioid receptor Ki 16.4 nM 10.1021/jm00073a020
Rattus norvegicus Delta opioid receptor Ki 17.7 nM 10.1021/jm00082a008
Rattus norvegicus Delta opioid receptor Potency 0.154 None 10.1021/jm00073a020
Rattus norvegicus Kappa opioid receptor Ki nan None 10.1016/j.ejmech.2014.12.016
Rattus norvegicus Mu opioid receptor IC50 385.0 nM 10.1021/jm00123a023
Rattus norvegicus Mu opioid receptor IC50 609.0 nM 10.1021/jm00091a006
Rattus norvegicus Mu opioid receptor IC50 609.0 nM 10.1021/jm00163a041
Rattus norvegicus Mu opioid receptor IC50 609.0 nM 10.1021/jm980374r
Rattus norvegicus Mu opioid receptor IC50 619.0 nM 10.1021/jm00110a010
Rattus norvegicus Mu opioid receptor IC50 620.0 nM 10.1021/jm00027a018
Rattus norvegicus Mu opioid receptor IC50 620.0 nM 10.1021/jm00037a007
Rattus norvegicus Mu opioid receptor IC50 1300.0 nM 10.1021/jm00109a019
Rattus norvegicus Mu opioid receptor IC50 3700.0 nM 10.1021/jm9704762
Rattus norvegicus Mu opioid receptor Ki 610.0 nM 10.1021/jm100157m
Rattus norvegicus Mu opioid receptor Ki 610.0 nM 10.1021/jm900473p
Rattus norvegicus Mu opioid receptor Ki 873.0 nM 10.1021/jm00118a005
Rattus norvegicus Mu opioid receptor Ki 873.0 nM 10.1021/jm00397a019
Rattus norvegicus Mu opioid receptor Ki 943.0 nM 10.1021/jm00073a020
Rattus norvegicus Mu opioid receptor Ki 2018.0 nM 10.1021/jm00082a008
Rattus norvegicus Mu opioid receptor Ki 2120.0 nM 10.1016/j.bmc.2010.06.005
Rattus norvegicus Mu opioid receptor Ki 2820.0 nM 10.1016/j.bmcl.2012.01.063
Rattus norvegicus Mu opioid receptor Log EC50 nan None 10.1021/jm050921q
Rattus norvegicus Mu opioid receptor Log IC50 nan None 10.1021/jm050921q
Rattus norvegicus Mu opioid receptor Potency 0.01 None 10.1021/jm00073a020
Rattus norvegicus Mu opioid receptor Ratio 73.0 None 10.1021/jm00037a007
Rattus norvegicus Mu opioid receptor Ratio 116.0 None 10.1021/jm00163a041
Rattus norvegicus Mu opioid receptor Ratio 380.0 None 10.1021/jm00091a006
Rattus norvegicus Opioid receptors; mu & delta Ratio 0.012 None 10.1021/jm00118a005
Rattus norvegicus Opioid receptors; mu & delta Ratio 0.012 None 10.1021/jm00397a019
Rattus norvegicus Rattus norvegicus ED50 54.0 ug 10.1021/jm970861r
Rattus norvegicus Rattus norvegicus ED50 130.0 nM 10.1021/jm020108k
Rattus norvegicus Solute carrier organic anion transporter family member 1A1 Km 48000.0 nM None
Rattus norvegicus Solute carrier organic anion transporter family member 1A4 Km 19000.0 nM None
Rattus norvegicus Solute carrier organic anion transporter family member 1A5 Km 137000.0 nM 10.1007/s004240100697
Rattus norvegicus Solute carrier organic anion transporter family member 1B2 Km 22000.0 nM 10.1007/s004240100697
Trichomonas vaginalis Trichomonas vaginalis MIC 320000.0 nM 10.1016/j.bmcl.2015.06.002
None No relevant target LogP 1.0 None 10.1021/jm021012t
None Unchecked IC50 3.7 nM 10.1021/jm8007618
None Unchecked IC50 1000.0 nM 10.1021/jm00044a006
None Unchecked IC50 6340.0 nM 10.1016/j.bmcl.2012.01.063
None Unchecked Ki 2.2 nM 10.1021/jm8007618
None Unchecked Ki 370.0 nM 10.1021/jm900473p
None Unchecked Ratio 0.00025 None 10.1021/jm00118a005
None Unchecked Ratio 224.0 None 10.1021/jm00109a019
None Unchecked Ratio 1800.0 None 10.1021/jm00040a002
None Unchecked Ratio 1800.0 None 10.1021/jm950695s
None Unchecked Ratio 1800.0 None 10.1021/jm960319n
None Unchecked Ratio 2075.0 None 10.1021/jm00109a019
None Unchecked Ratio 3810.0 None 10.1021/jm00123a023
None Unchecked Ratio IC50 380.0 None 10.1021/jm100157m
None Unchecked Ratio Ki 50.0 None 10.1021/jm2003238
None Unchecked Ratio Ki 336.0 None 10.1016/j.bmcl.2012.01.063
None Unchecked Selectivity 380.0 None 10.1021/jm00038a004
None Unchecked Selectivity 1800.0 None 10.1021/jm00027a018
None Unchecked Selectivity ratio 1810.0 None 10.1021/jm00110a010

Metabolism Information