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Cytochalasin D

AlkaPlorer ID: AK326061

Synonym: None

IUPAC Name: [(3E,9E)-16-benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-6,18-dioxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl] acetate

Structure

SMILES: C=C1C(C)C2C(CC3=CC=CC=C3)N=C(O)C23C(OC(C)=O)/C=C/C(C)(O)C(=O)C(C)C/C=C/C3C1O

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InChI: InChI=1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+

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InChIKey: SDZRWUKZFQQKKV-BBXOWAOSSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Zygosporium masonii Zygosporium Zygosporiaceae Xylariales Sordariomycetes Ascomycota Fungi Eukaryota

Properties Information

Molecule Weight: 507.6270000000003

TPSA？: 116.42

MolLogP？: 3.757400000000004

Number of H-Donors: 3

Number of H-Acceptors: 6

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens 786-0 GI50 311.17 nM None
Homo sapiens A498 GI50 177.42 nM None
Homo sapiens A549 GI50 763.84 nM None
Homo sapiens ACHN GI50 889.2 nM None
Homo sapiens BT-549 GI50 407.38 nM None
Homo sapiens CAKI-1 GI50 129.42 nM None
Homo sapiens CCRF-CEM GI50 4236.43 nM None
Homo sapiens COLO 205 GI50 534.56 nM None
Homo sapiens DLD-1 GI50 779.83 nM None
Homo sapiens DMS-114 GI50 8709.64 nM None
Homo sapiens DMS-273 GI50 1958.84 nM None
Homo sapiens DU-145 GI50 28183.83 nM None
Homo sapiens EKVX GI50 1803.02 nM None
Homo sapiens HCC 2998 GI50 21727.01 nM None
Homo sapiens HCT-116 GI50 3539.97 nM None
Homo sapiens HCT-15 GI50 5546.26 nM None
Homo sapiens HL-60 GI50 4570.88 nM None
Homo sapiens HOP-18 GI50 35.48 nM None
Homo sapiens HOP-62 GI50 67.76 nM None
Homo sapiens HOP-92 GI50 568.85 nM None
Homo sapiens Hs-578T GI50 65.16 nM None
Homo sapiens HT-29 GI50 132.43 nM None
Homo sapiens IGROV-1 GI50 901.57 nM None
Homo sapiens K562 GI50 33113.11 nM None
Homo sapiens KM12 GI50 90782.05 nM None
Homo sapiens KM-20L2 GI50 158.12 nM None
Homo sapiens LOX IMVI GI50 101.16 nM None
Homo sapiens LXFL 529 GI50 3140.51 nM None
Homo sapiens M14 GI50 7244.36 nM None
Homo sapiens M19-MEL GI50 16143.59 nM None
Homo sapiens Malme-3M GI50 30549.21 nM None
Homo sapiens MCF7 GI50 6760.83 nM None
Homo sapiens MDA-MB-231 GI50 151.36 nM None
Homo sapiens MDA-MB-435 GI50 51050.5 nM None
Homo sapiens MDA-N GI50 15559.66 nM None
Homo sapiens MOLT-4 GI50 15066.07 nM None
Homo sapiens NCI/ADR-RES GI50 65917.39 nM None
Homo sapiens NCI-H226 GI50 3854.78 nM None
Homo sapiens NCI-H23 GI50 12912.19 nM None
Homo sapiens NCI-H322M GI50 58344.51 nM None
Homo sapiens NCI-H460 GI50 258.23 nM None
Homo sapiens NCI-H522 GI50 2426.61 nM None
Homo sapiens OVCAR-3 GI50 22438.82 nM None
Homo sapiens OVCAR-4 GI50 3548.13 nM None
Homo sapiens OVCAR-5 GI50 68865.23 nM None
Homo sapiens OVCAR-8 GI50 79799.47 nM None
Homo sapiens PC-3 GI50 11721.95 nM None
Homo sapiens RPMI-8226 GI50 5984.12 nM None
Homo sapiens RXF 393 GI50 86.5 nM None
Homo sapiens RXF 631 GI50 116.95 nM None
Homo sapiens SF-268 GI50 1448.77 nM None
Homo sapiens SF-295 GI50 365.59 nM None
Homo sapiens SF-539 GI50 117.22 nM None
Homo sapiens SK-MEL-2 GI50 6223.0 nM None
Homo sapiens SK-MEL-28 GI50 2466.04 nM None
Homo sapiens SK-MEL-5 GI50 760.33 nM None
Homo sapiens SK-OV-3 GI50 751.62 nM None
Homo sapiens SN12C GI50 39264.49 nM None
Homo sapiens SN12K1 GI50 61.94 nM None
Homo sapiens SNB-19 GI50 216.77 nM None
Homo sapiens SNB-75 GI50 33.34 nM None
Homo sapiens SNB-78 GI50 116.41 nM None
Homo sapiens SR GI50 3296.1 nM None
Homo sapiens SW-620 GI50 87700.08 nM None
Homo sapiens T47D GI50 58884.37 nM None
Homo sapiens TK-10 GI50 504.66 nM None
Homo sapiens U-251 GI50 92.47 nM None
Homo sapiens UACC-257 GI50 6591.74 nM None
Homo sapiens UACC-62 GI50 3357.38 nM None
Homo sapiens UO-31 GI50 295.8 nM None
Homo sapiens XF498 GI50 2009.09 nM None
Mus musculus P388 GI50 453.94 nM None
Mus musculus P388/ADR GI50 14387.99 nM None

Metabolism Information