Flutimide
AlkaPlorer ID: AK326251
Synonym: None
IUPAC Name: (5Z)-1-hydroxy-3-(2-methylpropyl)-5-(2-methylpropylidene)pyrazine-2,6-dione
Structure
SMILES: CC(C)/C=C1\N=C(CC(C)C)C(=O)N(O)C1=O
InChI: InChI=1S/C12H18N2O3/c1-7(2)5-9-11(15)14(17)12(16)10(13-9)6-8(3)4/h5,7-8,17H,6H2,1-4H3/b9-5-
InChIKey: SIXHCCPAJIVTOY-UITAMQMPSA-N
Reference
Isolation and structure of flutimide, a novel endonuclease inhibitor of influenza virus
PubChem CID: 6443207
CAS: 162666-34-4
LOTUS: LTS0217880
SuperNatural Ⅲ: SN0346722-01
{NPAtlas: NPA017441
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| None | Otto | Siluaniidae | Bicosoecida | Bigyra | None | None | Eukaryota |
Properties Information
Molecule Weight: 238.287
TPSA？: 69.97
MolLogP？: 1.7714
Number of H-Donors: 1
Number of H-Acceptors: 4
RingCount: 1
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | Polymerase acidic protein | IC50 | 5100.0 | nM | 10.1021/acs.jmedchem.6b01227 |
| Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | Polymerase acidic protein | IC50 | 5100.0 | nM | 10.1021/jo015665d |
| Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | Polymerase acidic protein | IC50 | 5500.0 | nM | 10.1021/jm020334u |
| Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | Polymerase acidic protein | IC50 | 5500.0 | nM | 10.1039/C5MD00439J |
| unidentified influenza virus | unidentified influenza virus | IC50 | 5500.0 | nM | 10.1016/j.bmc.2008.11.075 |
| None | Unchecked | IC50 | 5495.41 | nM | 10.1016/j.bmcl.2013.12.026 |