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name Structure Reference Source Properties Activities Metabolism

6-Amino-5,6,7,8-tetrahydro-naphthalene-2,3-diol

AlkaPlorer ID: AK336467

Synonym: None

IUPAC Name: 6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol

Structure

SMILES: NC1CCC2=CC(O)=C(O)C=C2C1

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InChI: InChI=1S/C10H13NO2/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8/h4-5,8,12-13H,1-3,11H2

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InChIKey: ASXGAOFCKGHGMF-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Apis mellifera Apis Apidae Hymenoptera Insecta Arthropoda Metazoa Eukaryota

Properties Information

Molecule Weight: 179.21899999999997

TPSA？: 66.48

MolLogP？: 0.9137999999999996

Number of H-Donors: 3

Number of H-Acceptors: 3

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 39810.7 nM None
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 56234.1 nM None
Bos taurus Dopamine D2 receptor Displacement nan None 10.1021/jm00150a010
Bos taurus Dopamine D2 receptor Kb 210.0 nM 10.1021/jm00150a010
Bos taurus Dopamine D2 receptor K Bind 0.21 uM 10.1021/jm00159a010
Bos taurus Dopamine receptor IC50 6.0 nM 10.1021/jm00349a017
Canis lupus familiaris Canis familiaris BP 29.0 mmHg 10.1021/jm00139a013
Canis lupus familiaris Canis familiaris BP 61.0 mmHg 10.1021/jm00139a013
Canis lupus familiaris Canis familiaris HR -12.0 beats min-1 10.1021/jm00139a013
Canis lupus familiaris Canis familiaris HR 21.0 beats min-1 10.1021/jm00139a013
Canis lupus familiaris Canis familiaris Potency 173.0 nM kg-1 10.1021/jm00139a013
Canis lupus familiaris Canis familiaris Potency 457.0 nM kg-1 10.1021/jm00139a013
Cavia porcellus Cavia porcellus EC50 2500.0 nM 10.1021/jm00139a013
Cavia porcellus Cavia porcellus EC50 33000.0 nM 10.1021/jm00139a013
Cavia porcellus Cavia porcellus RIA 0.61 None 10.1021/jm00139a013
Cavia porcellus Cavia porcellus RIA 1.06 None 10.1021/jm00139a013
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 7943.3 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 39810.7 nM None
Homo sapiens Cerebroside-sulfatase Potency 1069.1 nM None
Homo sapiens Chromobox protein homolog 1 Potency 56234.1 nM None
Homo sapiens Dopamine D1 receptor Potency 16.4 nM None
Homo sapiens Dopamine D1 receptor Potency 51.7 nM None
Homo sapiens Dopamine D1 receptor Potency 89.1 nM None
Homo sapiens Dopamine D1 receptor Potency 158.5 nM None
Homo sapiens Dopamine D2 receptor IC50 4e-08 nM 10.1021/jm00382a002
Homo sapiens Flap endonuclease 1 Potency 1191.7 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 1500.3 nM None
Homo sapiens Microtubule-associated protein tau Potency 3548.1 nM None
Homo sapiens Microtubule-associated protein tau Potency 5011.9 nM None
Homo sapiens Microtubule-associated protein tau Potency 10000.0 nM None
Homo sapiens Microtubule-associated protein tau Potency 15848.9 nM None
Homo sapiens Microtubule-associated protein tau Potency 44668.4 nM None
Homo sapiens M-phase phosphoprotein 8 Potency 37685.8 nM None
Homo sapiens Regulator of G-protein signaling 4 Potency 75.2 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 12995.3 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 16360.1 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 19952.6 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 22387.2 nM None
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 2 Potency 1166.8 nM None
Mus musculus Mus musculus IC50 10.0 nM 10.1021/jm00371a021
Oryctolagus cuniculus Oryctolagus cuniculus EC50 17.0 nM 10.1021/jm00155a024
Oryctolagus cuniculus Oryctolagus cuniculus ED50 4.6 nM 10.1021/jm00150a010
Oryctolagus cuniculus Oryctolagus cuniculus ED50 4.6 uM 10.1021/jm00159a010
Rattus norvegicus Dopamine D1 receptor EC50 1.3 None 10.1021/jm00150a010
Rattus norvegicus Dopamine D1 receptor ED50 2.7 uM 10.1021/jm00159a010
Rattus norvegicus Dopamine D1 receptor Inhibition nan % 10.1021/jm00150a010
Rattus norvegicus Dopamine D1 receptor K Bind 0.07 uM 10.1021/jm00159a010
Rattus norvegicus Dopamine D2 receptor IC50 700.0 nM 10.1021/jm980284m
Rattus norvegicus Dopamine D2 receptor Ki 65.7 nM 10.1021/jm00163a029
Rattus norvegicus Dopamine receptor IC50 1.7 nM 10.1021/jm00346a007
Rattus norvegicus Dopamine receptor IC50 3.0 nM 10.1021/jm00346a007
Rattus norvegicus Dopamine receptor IC50 3.1 nM 10.1021/jm00349a017
Rattus norvegicus Dopamine transporter Activity 22.1 % 10.1021/jm00206a023
Rattus norvegicus Dopamine transporter Activity 25.1 % 10.1021/jm00206a023
Rattus norvegicus Dopamine transporter Activity nan None 10.1021/jm00206a023
Rattus norvegicus Rattus norvegicus IC50 24.5 nM 10.1021/jm00376a020
Rattus norvegicus Rattus norvegicus Ki 12.0 nM 10.1021/jm00376a020
Rattus norvegicus Serotonin transporter Activity nan None 10.1021/jm00206a023
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 2119.2 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 11917.3 nM None
Rattus norvegicus Vesicular acetylcholine transporter Activity nan None 10.1021/jm00206a023
Trypanosoma brucei 6-phospho-1-fructokinase Potency 535.8 nM None
None No relevant target LogP 1.88 None 10.1021/jm00376a020
None No relevant target pKa 9.84 None 10.1021/jm00348a018
None No relevant target pKa_A1 9.1 None 10.6019/CHEMBL3301361
None No relevant target pKa_B1 10.5 None 10.6019/CHEMBL3301361
None Unchecked Activity nan None 10.1021/jm00206a023
None Unchecked Increase 5.0 % 10.1021/jm00139a013
None Unchecked Potency 22387.2 nM None
None Unchecked Potency 31622.8 nM None

Metabolism Information