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name Structure Reference Source Properties Activities Metabolism

6-nitroquinolin-8-ol

AlkaPlorer ID: AK348744

Synonym: None

IUPAC Name: 6-nitroquinolin-8-ol

Structure

SMILES: O=[N+]([O-])C1=CC2=CC=CN=C2C(O)=C1

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InChI: InChI=1S/C9H6N2O3/c12-8-5-7(11(13)14)4-6-2-1-3-10-9(6)8/h1-5,12H

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InChIKey: BVBQGQLGXJDKLZ-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 190.158

TPSA？: 76.26

MolLogP？: 1.8486

Number of H-Donors: 1

Number of H-Acceptors: 4

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Candida albicans (strain WO-1) (Yeast) ATP-dependent molecular chaperone HSP82 EC50 763.0 nM None
Candida albicans (strain WO-1) (Yeast) ATP-dependent molecular chaperone HSP82 EC50 12331.0 nM None
Candida albicans (strain WO-1) (Yeast) ATP-dependent molecular chaperone HSP82 EC50 18536.0 nM None
Candida dubliniensis (strain CD36 / CBS 7987 / NCPF 3949 / NRRLY-17841) (Yeast) Serine/threonine-protein phosphatase EC50 180000.0 nM None
Escherichia coli Beta-galactosidase IC50 66600.0 nM None
Escherichia coli (strain K12) Exodeoxyribonuclease V IC50 62272.0 nM None
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Potency 4456.3 nM None
Homo sapiens Alpha-synuclein Potency 6309.6 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 2591.8 nM None
Homo sapiens Bromodomain adjacent to zinc finger domain protein 2B Potency 5623.4 nM None
Homo sapiens Caspase-6 AC50 17260.0 nM None
Homo sapiens C-C chemokine receptor type 6 IC50 66600.0 nM None
Homo sapiens DNA dC->dU-editing enzyme APOBEC-3G Potency 11220.2 nM None
Homo sapiens DNA polymerase iota Potency 100000.0 nM None
Homo sapiens Flap endonuclease 1 Potency 2818.4 nM None
Homo sapiens Geminin Potency 730.8 nM None
Homo sapiens Geminin Potency 15848.9 nM None
Homo sapiens Glucagon-like peptide 1 receptor Potency 501.2 nM None
Homo sapiens Glycoprotein hormones alpha chain Potency 2818.4 nM None
Homo sapiens HEK293 Potency 11220.2 nM None
Homo sapiens HepG2 Potency 3981.1 nM None
Homo sapiens Huntingtin Potency 4466.8 nM None
Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Potency 1835.6 nM None
Homo sapiens Lysine-specific demethylase 4A Potency 17782.8 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 2818.4 nM None
Homo sapiens microRNA 21 Potency 16481.6 nM None
Homo sapiens Microtubule-associated protein tau Potency 11220.2 nM None
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 5011.9 nM None
Homo sapiens Muscleblind-like protein 1 Potency 22387.2 nM None
Homo sapiens Niemann-Pick C1 protein Potency 6309.6 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 5623.4 nM None
Homo sapiens Nuclear factor NF-kappa-B complex EC50 7941.0 nM None
Homo sapiens Parathyroid hormone receptor Potency 3981.1 nM None
Homo sapiens Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Potency 84921.4 nM None
Homo sapiens Pyruvate kinase isozymes M1/M2 Potency 28183.8 nM None
Homo sapiens Ras-related protein Rab-9A Potency 3981.1 nM None
Homo sapiens Survival motor neuron protein Potency 25118.9 nM None
Homo sapiens TAR DNA-binding protein 43 Potency 39810.7 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 8.2 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 25.9 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 15848.9 nM None
Human immunodeficiency virus 1 Aberrant vpr protein Potency 7943.3 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 891.3 nM None
Mycobacterium tuberculosis Protein RecA EC50 4600.0 nM None
Mycobacterium tuberculosis Replicative DNA helicase AC50 6954.0 nM None
Mycobacterium tuberculosis Replicative DNA helicase AC50 8427.0 nM None
Plasmodium falciparum Plasmodium falciparum Potency 1471.6 nM None
Plasmodium falciparum Plasmodium falciparum Potency 18526.0 nM None
Saccharomyces cerevisiae S288c Mitochondrial import inner membrane translocase subunit TIM10 IC50 7750.0 nM None
Saccharomyces cerevisiae S288c Mitochondrial import inner membrane translocase subunit TIM23 IC50 11400.0 nM None
None Unchecked EC50 706.0 nM None
None Unchecked EC50 5780.0 nM None
None Unchecked EC50 6480.0 nM None
None Unchecked EC50 13300.0 nM None
None Unchecked EC50 42123.0 nM None
None Unchecked EC50 80000.0 nM None
None Unchecked IC50 2710.0 nM None
None Unchecked IC50 12135.0 nM None
None Unchecked IC50 14250.0 nM None
None Unchecked IC50 15750.0 nM None
None Unchecked IC50 15940.0 nM None
None Unchecked IC50 16750.0 nM None
None Unchecked IC50 22669.0 nM None
None Unchecked IC50 27930.0 nM None
None Unchecked IC50 41484.0 nM None
None Unchecked IC50 46526.0 nM None
None Unchecked IC50 84949.0 nM None
None Unchecked Inhibition 20.0 % 10.1016/j.ejmech.2021.113975
None Unchecked Inhibition 95.0 % 10.1016/j.ejmech.2021.113975
None Unchecked Potency 446.7 nM None
None Unchecked Potency 562.3 nM None
None Unchecked Potency 1000.0 nM None
None Unchecked Potency 2310.9 nM None
None Unchecked Potency 5011.9 nM None
None Unchecked Potency 5623.4 nM None
None Unchecked Potency 12589.3 nM None

Metabolism Information