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Nitenpyram

AlkaPlorer ID: AK353249

Synonym: None

IUPAC Name: (E)-1-N'-[(6-chloropyridin-3-yl)methyl]-1-N'-ethyl-1-N-methyl-2-nitroethene-1,1-diamine

Structure

SMILES: CCN(CC1=CC=C(Cl)N=C1)/C(=C/[N+](=O)[O-])NC

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InChI: InChI=1S/C11H15ClN4O2/c1-3-15(11(13-2)8-16(17)18)7-9-4-5-10(12)14-6-9/h4-6,8,13H,3,7H2,1-2H3/b11-8+

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InChIKey: CFRPSFYHXJZSBI-DHZHZOJOSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Streptomyces canus Streptomyces Streptomycetaceae Kitasatosporales Actinomycetes Actinomycetota None Bacteria

Properties Information

Molecule Weight: 270.72

TPSA？: 71.3

MolLogP？: 1.8519

Number of H-Donors: 1

Number of H-Acceptors: 5

RingCount: 1

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Agaricus bisporus Tyrosinase IC50 1000000.0 nM 10.1021/jf200485k
Agaricus bisporus Tyrosinase Inhibition 0.0 % 10.1021/jf200485k
Anopheles gambiae Anopheles gambiae LC25 78.65 ng/ml 10.1021/acs.jmedchem.1c00498
Anopheles gambiae Anopheles gambiae LC50 0.111 ug.mL-1 10.1021/acs.jmedchem.1c00498
Aphis gossypii Aphis gossypii Activity 0.17 mg 10.1002/ps.2207
Aphis gossypii Aphis gossypii Activity 0.2 mg 10.1002/ps.2207
Aphis gossypii Aphis gossypii Activity 0.22 mg 10.1002/ps.2207
Aphis gossypii Aphis gossypii Activity nan None 10.1002/ps.2207
Aphis gossypii Aphis gossypii Inhibition 28.3 % 10.1002/ps.2207
Aphis gossypii Aphis gossypii LC20 10.5 ug ml-1 10.1002/ps.2207
Aphis gossypii Aphis gossypii LC50 2.47 microg/mL2 10.1002/ps.2207
Aphis gossypii Aphis gossypii LC50 14.3 microg/mL2 10.1002/ps.2207
Aphis gossypii Aphis gossypii RatioLC50 5.78 None 10.1002/ps.2207
Aphis gossypii Aphis gossypii Survival 8.42 day 10.1002/ps.2207
Bemisia tabaci Bemisia tabaci LC50 0.99 ug.mL-1 10.1002/ps.1808
Bemisia tabaci Bemisia tabaci LC50 2.22 ug.mL-1 10.1002/ps.1877
Bemisia tabaci Bemisia tabaci LC50 22.2 ug.mL-1 10.1002/ps.1877
Bemisia tabaci Bemisia tabaci LC50 93.0 ug.mL-1 10.1002/ps.1808
Bemisia tabaci Bemisia tabaci RatioLC50 9.99 None 10.1002/ps.1877
Bemisia tabaci Bemisia tabaci RatioLC50 94.0 None 10.1002/ps.1808
Cheumatopsyche Cheumatopsyche EC50 0.045 ug.mL-1 10.1584/jpestics.G08-26
Daphnia magna Daphnia magna EC50 100.0 ug.mL-1 10.1584/jpestics.G08-26
Drosophila melanogaster Acetylcholine receptor subunit beta-like 2 IC50 11.0 nM 10.1046/j.1471-4159.2000.751294.x
Empoasca Empoasca LC95 40.0 ppm 10.1021/jf203068a
Glycine max Glycine max Activity nan None 10.1021/jf200485k
Gossypium hirsutum Gossypium hirsutum Activity nan None 10.1021/jf200485k
Homo sapiens Histone deacetylase 6 Inhibition 2.26 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 2.38 % 10.6019/CHEMBL4808148
Myzus persicae Myzus persicae LC100 0.129 mg/L 10.1021/jf3024479
Myzus persicae Myzus persicae LC50 1.3 ppm 10.1002/ps.3413
Myzus persicae Myzus persicae LC50 236.0 ppm 10.1002/ps.3413
Myzus persicae Myzus persicae mortality 100.0 % 10.1021/jf3024479
Nilaparvata lugens Nilaparvata lugens LC50 0.129 ug.mL-1 10.1021/jf1049563
Nilaparvata lugens Nilaparvata lugens LC50 0.129 ug.mL-1 10.1021/jf3024479
Nilaparvata lugens Nilaparvata lugens mortality 100.0 % 10.1016/j.bmcl.2010.04.050
Nilaparvata lugens Nilaparvata lugens mortality 100.0 % 10.1021/jf1049563
Nilaparvata lugens Nilaparvata lugens mortality 100.0 % 10.1021/jf3024479
Oryctolagus cuniculus Aldehyde oxidase IC50 1000000.0 nM 10.1021/jf200485k
Oryctolagus cuniculus Aldehyde oxidase Inhibition 1.0 % 10.1021/jf200485k
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition -4.93 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.05857 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -5.0 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.18 % 10.6019/CHEMBL4495565
Torpedo californica Acetylcholine receptor protein alpha chain Activity 142.0 % 10.1584/jpestics.20.49
Torpedo californica Acetylcholine receptor protein alpha chain Activity 607.0 % 10.1584/jpestics.20.49
Torpedo californica Acetylcholine receptor protein alpha chain IC50 300000.0 nM 10.1584/jpestics.20.33
Torpedo californica Acetylcholine receptor protein alpha chain IC50 300000.0 nM 10.1584/jpestics.20.49
Torpedo californica Acetylcholine receptor protein alpha chain Inhibition 2.39 % 10.1584/jpestics.20.33
Torpedo californica Acetylcholine receptor protein alpha chain Inhibition 2.39 % 10.1584/jpestics.20.49
Trichogramma nubilale Trichogramma nubilale LC50 4.37 mgAi/L 10.1016/j.cropro.2011.12.007
Trichogramma nubilale Trichogramma nubilale LC95 31.37 mgAi/L 10.1016/j.cropro.2011.12.007
Trichogramma nubilale Trichogramma nubilale Ratio 6.86 None 10.1016/j.cropro.2011.12.007
Vitis vinifera Vitis vinifera Activity nan None 10.1021/jf200485k
Zea mays Zea mays Activity nan None 10.1021/jf200485k
None No relevant target log KOW -0.66 None 10.1584/jpestics.G08-26
None Unchecked Ac50 0.631 uM None
None Unchecked Ac50 0.7079 uM None
None Unchecked Ac50 1.122 uM None
None Unchecked AC50 631.0 nM None
None Unchecked AC50 707.9 nM None
None Unchecked AC50 1122.0 nM None
None Unchecked IC50 21.0 nM 10.1046/j.1471-4159.2000.751294.x
None Unchecked IC50 27600.0 nM 10.1584/jpestics.20.57
None Unchecked IC50 61300.0 nM 10.1584/jpestics.20.33
None Unchecked IC50 61300.0 nM 10.1584/jpestics.20.57
None Unchecked IC50 1000000.0 nM 10.1021/jf200485k
None Unchecked Inhibition -7.0 % 10.1021/jf200485k
None Unchecked Ki 0.19 nM 10.1002/ps.3413
None Unchecked Ki 3.5 nM 10.1002/ps.3413
None Unchecked Ki 180.0 nM 10.1073/pnas.0703309104
None Unchecked Ki 335.0 nM 10.1073/pnas.0703309104
None Unchecked Ratio 182.0 None 10.1002/ps.3413
None Unchecked Ratio EC50 3.35 None 10.1584/jpestics.G08-26

Metabolism Information