Navigation

name Structure Reference Source Properties Activities Metabolism

Sanguinarium

AlkaPlorer ID: AK413007

Synonym: None

IUPAC Name: 24-methyl-5,7,18,20-tetraoxa-24-azoniahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-1(24),2,4(8),9,11,13,15,17(21),22-nonaene

Structure

SMILES: C[N+]1=CC2=C3OCOC3=CC=C2C2=CC=C3C=C4OCOC4=CC3=C21

copy

InChI: InChI=1S/C20H14NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-8H,9-10H2,1H3/q+1

copy

InChIKey: INVGWHRKADIJHF-UHFFFAOYSA-N

copy

Source

Species Genus Family Order Class Phylum Kingdom Domain
Chelidonium majus Chelidonium Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 332.3350000000001

TPSA？: 40.8

MolLogP？: 3.4281000000000024

Number of H-Donors: 0

Number of H-Acceptors: 4

RingCount: 6

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Actinomyces viscosus Actinomyces viscosus MIC 15.0 ug.mL-1 10.1021/np960451q
Bacillus anthracis Anthrax lethal factor Potency 10000.0 nM None
Bacillus anthracis Anthrax lethal factor Potency 15848.9 nM None
Bacillus pumilus Bacillus pumilus MBC 32.0 ug ml-1 10.1016/j.ejmech.2021.113723
Bacillus pumilus Bacillus pumilus MIC 4.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Bacillus pumilus Bacillus pumilus Ratio 8.0 None 10.1016/j.ejmech.2021.113723
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 8912.5 nM None
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 10000.0 nM None
Bacillus subtilis Bacillus subtilis Activity nan None 10.1039/c2md20127e
Bacillus subtilis Bacillus subtilis MBC 128.0 ug ml-1 10.1016/j.ejmech.2021.113723
Bacillus subtilis Bacillus subtilis MIC 2.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Bacillus subtilis Bacillus subtilis MIC 8.0 ug.mL-1 10.1016/j.bmcl.2017.06.005
Bacillus subtilis Bacillus subtilis MIC 10000.0 nM 10.1039/c2md20127e
Bacillus subtilis (strain 168) DNA polymerase III Potency 8436.8 nM None
Cavia porcellus Cavia porcellus Relaxation -89.0 % 10.1016/s0960-894x(98)00056-0
Electrophorus electricus Acetylcholinesterase Inhibition 26.96 % 10.1016/j.bmc.2012.09.040
Enterococcus faecalis Enterococcus faecalis MBC 64.0 ug ml-1 10.1016/j.ejmech.2021.113723
Enterococcus faecalis Enterococcus faecalis MIC 8.0 ug.mL-1 10.1016/j.ejmech.2012.12.027
Enterococcus faecalis Enterococcus faecalis MIC 16.0 ug.mL-1 10.1016/j.ejmech.2012.12.027
Enterococcus faecalis Enterococcus faecalis MIC 16.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Enterococcus faecalis Enterococcus faecalis MIC 32.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Enterococcus faecalis Enterococcus faecalis MIC=>90 8.0 ug ml-1 10.1016/j.bmcl.2013.02.016
Enterococcus faecalis Enterococcus faecalis MIC=>90 16.0 ug ml-1 10.1016/j.bmcl.2013.02.016
Enterococcus faecalis Enterococcus faecalis MIC90 8.0 ug.mL-1 10.1016/j.bmc.2012.10.009
Enterococcus faecalis Enterococcus faecalis MIC90 16.0 ug.mL-1 10.1016/j.bmc.2012.10.009
Enterococcus faecium Enterococcus faecium MBC 64.0 ug ml-1 10.1016/j.ejmech.2021.113723
Enterococcus faecium Enterococcus faecium MIC 32.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Enterococcus faecium Enterococcus faecium MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Equus caballus Cholinesterase Inhibition 1.3 % 10.1016/j.bmc.2012.09.040
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1016/j.bmcl.2017.06.005
Escherichia coli K-12 Cell division protein ftsZ IC50 3000.0 nM 10.1016/j.ejmech.2020.112132
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Potency 6294.6 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 14125.4 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 28183.8 nM None
Homo sapiens 78 kDa glucose-regulated protein Potency 4140.0 nM None
Homo sapiens 78 kDa glucose-regulated protein Potency 7079.5 nM None
Homo sapiens A549 IC50 610.0 nM 10.1021/acs.jnatprod.7b00112
Homo sapiens Acetylcholinesterase IC50 1220.0 nM 10.1016/j.ejmech.2020.112415
Homo sapiens Acetylcholinesterase Inhibition 91.2 % 10.1016/j.ejmech.2020.112415
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 22387.2 nM None
Homo sapiens Alpha-synuclein Potency 29092.9 nM None
Homo sapiens Alpha-synuclein Potency 35481.3 nM None
Homo sapiens Arachidonate 12-lipoxygenase Potency 10000.0 nM None
Homo sapiens Arachidonate 12-lipoxygenase Potency 12589.3 nM None
Homo sapiens Arachidonate 15-lipoxygenase Potency 3162.3 nM None
Homo sapiens Arachidonate 15-lipoxygenase Potency 7943.3 nM None
Homo sapiens Arachidonate 15-lipoxygenase, type II Potency 3981.1 nM None
Homo sapiens Ataxin-2 Potency 1995.3 nM None
Homo sapiens Ataxin-2 Potency 5623.4 nM None
Homo sapiens Ataxin-2 Potency 6309.6 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 580.2 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 2908.1 nM None
Homo sapiens Bcl2-antagonist of cell death (BAD) IC50 19000.0 nM 10.1021/jm8005433
Homo sapiens Butyrylcholinesterase IC50 7080.0 nM 10.1016/j.ejmech.2020.112415
Homo sapiens Cellular tumor antigen p53 Potency 2511.9 nM None
Homo sapiens Cellular tumor antigen p53 Potency 3162.3 nM None
Homo sapiens Cellular tumor antigen p53 Potency 6309.6 nM None
Homo sapiens Cellular tumor antigen p53 Potency 12589.3 nM None
Homo sapiens Cerebroside-sulfatase Potency 21331.3 nM None
Homo sapiens Chromobox protein homolog 1 Potency 9466.2 nM None
Homo sapiens Cytochrome P450 1A2 AC50 3981.07 nM None
Homo sapiens Cytochrome P450 1A2 AC50 10000.0 nM None
Homo sapiens Cytochrome P450 2C19 AC50 3162.28 nM None
Homo sapiens Cytochrome P450 2C19 AC50 6309.57 nM None
Homo sapiens Cytochrome P450 2C19 Potency 3162.3 nM None
Homo sapiens Cytochrome P450 2C19 Potency 6309.6 nM None
Homo sapiens Cytochrome P450 2C9 AC50 15848.93 nM None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 Potency 15848.9 nM None
Homo sapiens Cytochrome P450 2D6 AC50 7943.28 nM None
Homo sapiens Cytochrome P450 2D6 AC50 31622.78 nM None
Homo sapiens Cytochrome P450 2D6 Potency 7943.3 nM None
Homo sapiens Cytochrome P450 2D6 Potency 31622.8 nM None
Homo sapiens Cytochrome P450 3A4 AC50 3162.28 nM None
Homo sapiens Cytochrome P450 3A4 AC50 12589.25 nM None
Homo sapiens Cytochrome P450 3A4 Potency 3162.3 nM None
Homo sapiens Cytochrome P450 3A4 Potency 12589.3 nM None
Homo sapiens DNA dC->dU-editing enzyme APOBEC-3G Potency 3548.1 nM None
Homo sapiens DNA polymerase iota Potency 17782.8 nM None
Homo sapiens Dopamine D1 receptor Potency 4610.9 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 3981.1 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 12589.3 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 31622.8 nM None
Homo sapiens Fibrinogen beta chain IC50 24165.0 nM None
Homo sapiens Fibrinogen beta chain IC50 83135.0 nM None
Homo sapiens Flap endonuclease 1 Potency 26679.5 nM None
Homo sapiens Glutaminase kidney isoform, mitochondrial Potency 3162.3 nM None
Homo sapiens Guanine nucleotide-binding protein G(i) subunit alpha-1/Regulator of G-protein signaling 12 Potency 12589.3 nM None
Homo sapiens HEK293 Activity nan None 10.1021/acs.jnatprod.7b00112
Homo sapiens HEK293 Potency 1031.8 nM None
Homo sapiens HepG2 Potency 2818.4 nM None
Homo sapiens Histone acetyltransferase GCN5 Potency 15848.9 nM None
Homo sapiens Histone deacetylase 6 Inhibition 8.0 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 26.78 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 1888.8 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 12589.3 nM None
Homo sapiens Huntingtin Potency 6309.6 nM None
Homo sapiens Hypoxia-inducible factor 1 alpha Potency 7943.3 nM None
Homo sapiens Hypoxia-inducible factor 1 alpha Potency 10000.0 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 7079.5 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 25118.9 nM None
Homo sapiens MAP kinase ERK2 Potency 15848.9 nM None
Homo sapiens MAP kinase ERK2 Potency 25118.9 nM None
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 17782.8 nM None
Homo sapiens Microtubule-associated protein tau Potency 17782.8 nM None
Homo sapiens Microtubule-associated protein tau Potency 28183.8 nM None
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 2511.9 nM None
Homo sapiens Niemann-Pick C1 protein Potency 145809.7 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 18356.4 nM None
Homo sapiens Nuclear factor NF-kappa-B complex IC50 2000.0 nM 10.1016/j.bmc.2014.03.046
Homo sapiens Nuclear factor NF-kappa-B p105 subunit Potency 10000.0 nM None
Homo sapiens PC-3 GI nan None 10.1021/acs.jnatprod.7b00112
Homo sapiens Prelamin-A/C Potency 398.1 nM None
Homo sapiens Pyruvate kinase isozymes M1/M2 Potency 10000.0 nM None
Homo sapiens Ras-related protein Rab-9A Potency 46109.1 nM None
Homo sapiens Regulator of G-protein signaling 12 Potency 25118.9 nM None
Homo sapiens Regulator of G-protein signaling 17 Activity 16234.0 Da 10.1021/acs.jnatprod.7b00112
Homo sapiens Regulator of G-protein signaling 17 Activity nan None 10.1021/acs.jnatprod.7b00112
Homo sapiens Regulator of G-protein signaling 17 IC50 12000.0 nM 10.1021/acs.jnatprod.7b00112
Homo sapiens Regulator of G-protein signaling 17 IC50 72800.0 nM 10.1021/acs.jnatprod.7b00112
Homo sapiens Regulator of G-protein signaling 17 IC50 100000.0 nM 10.1021/acs.jnatprod.7b00112
Homo sapiens Regulator of G-protein signaling 17 Inhibition nan % 10.1021/acs.jnatprod.7b00112
Homo sapiens Regulator of G-protein signaling 17 Kd 1000.0 nM 10.1021/acs.jnatprod.7b00112
Homo sapiens Regulator of G-protein signaling 4 Potency 2119.2 nM None
Homo sapiens Regulator of G-protein signaling 4 Potency 17782.8 nM None
Homo sapiens Runt-related transcription factor 1/Core-binding factor subunit beta Potency 17782.8 nM None
Homo sapiens RWPE-1 GI nan None 10.1021/acs.jnatprod.7b00112
Homo sapiens Serine/threonine-protein kinase mTOR Potency 3288.5 nM None
Homo sapiens SH-SY5Y Potency 3548.1 nM None
Homo sapiens Signal transducer and activator of transcription 6 Potency 7943.3 nM None
Homo sapiens Signal transducer and activator of transcription 6 Potency 10000.0 nM None
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition -0.2 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 2.9 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition 15.0 % 10.1021/jm300212s
Homo sapiens Survival motor neuron protein Potency 11220.2 nM None
Homo sapiens Survival motor neuron protein Potency 22387.2 nM None
Homo sapiens T-24 Activity 639.2 U/mg 10.1016/j.ejmech.2010.10.006
Homo sapiens Thrombopoietin Potency 1000.0 nM None
Homo sapiens Thyroid stimulating hormone receptor Potency 12589.3 nM None
Homo sapiens Thyroid stimulating hormone receptor Potency 25118.9 nM None
Homo sapiens Tumor susceptibility gene 101 protein Potency 56234.1 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 580.5 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 819.9 nM None
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Potency 56234.1 nM None
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 2 Potency 25118.9 nM None
Homo sapiens Vitamin D receptor Potency 2818.4 nM None
Homo sapiens Vitamin D receptor Potency 7943.3 nM None
Homo sapiens Vitamin D receptor Potency 35481.3 nM None
Leishmania mexicana Pyruvate kinase Potency 10000.0 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 3162.3 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 6309.6 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 7079.5 nM None
Mycolicibacterium aurum Mycolicibacterium aurum MIC 24.5 ug.mL-1 10.1016/j.ejmech.2022.114173
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 24.5 ug.mL-1 10.1016/j.ejmech.2022.114173
Photinus pyralis Luciferin 4-monooxygenase Potency 7208.0 nM None
Photinus pyralis Luciferin 4-monooxygenase Potency 12589.3 nM None
Photinus pyralis Luciferin 4-monooxygenase Potency 15848.9 nM None
Plasmodium falciparum Plasmodium falciparum Potency 6745.6 nM None
Plasmodium falciparum Plasmodium falciparum Potency 16944.1 nM None
Porphyromonas gingivalis Porphyromonas gingivalis MIC 2.0 ug.mL-1 10.1021/np960451q
Porphyromonas gingivalis Porphyromonas gingivalis MIC 15.0 ug.mL-1 10.1021/np970524l
Prevotella intermedia Prevotella intermedia MIC 2.0 ug.mL-1 10.1021/np960451q
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1016/j.bmcl.2017.06.005
Rattus norvegicus Alanine aminotransferase Concentration 5e-05 M 10.1021/jm00141a019
Rattus norvegicus Alanine aminotransferase ID50 3.4e-06 M 10.1021/jm00141a019
Rattus norvegicus Alanine aminotransferase Inhibition 15.0 % 10.1021/jm00141a019
Rattus norvegicus Alanine aminotransferase Inhibition 20.0 % 10.1021/jm00141a019
Rattus norvegicus Alanine aminotransferase Inhibition 74.0 % 10.1021/jm00141a019
Rattus norvegicus Alanine aminotransferase Protection 5.0 % 10.1021/jm00141a019
Rattus norvegicus Alanine aminotransferase Protection 75.0 % 10.1021/jm00141a019
Rattus norvegicus Alanine aminotransferase Protection 81.0 % 10.1021/jm00141a019
Rattus norvegicus Inositol monophosphatase 1 Potency 10000.0 nM None
Rattus norvegicus Muscarinic acetylcholine receptor M1 Potency 141.3 nM None
Rattus norvegicus Muscarinic acetylcholine receptor M1 Potency 12589.3 nM None
Rattus norvegicus Peripheral myelin protein 22 Potency 8087.5 nM None
Rattus norvegicus Peripheral myelin protein 22 Potency 15836.9 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 31622.8 nM None
Saccharomyces cerevisiae Saccharomyces cerevisiae Potency 461.1 nM None
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1016/j.bmc.2011.11.052
Staphylococcus aureus Staphylococcus aureus EC50 24500.0 nM 10.1016/j.bmc.2011.11.052
Staphylococcus aureus Staphylococcus aureus MBC 34.0 uM 10.1016/j.bmc.2011.11.052
Staphylococcus aureus Staphylococcus aureus MBC 64.0 ug ml-1 10.1016/j.ejmech.2021.113723
Staphylococcus aureus Staphylococcus aureus MBC 128.0 ug ml-1 10.1016/j.ejmech.2021.113723
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.ejmech.2012.12.027
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1016/j.bmcl.2017.06.005
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1016/j.bmcl.2017.06.005
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Staphylococcus aureus Staphylococcus aureus MIC 34000.0 nM 10.1016/j.bmc.2011.11.052
Staphylococcus aureus Staphylococcus aureus MIC=>90 2.0 ug ml-1 10.1016/j.bmcl.2013.02.016
Staphylococcus aureus Staphylococcus aureus MIC90 2.0 ug.mL-1 10.1016/j.bmc.2012.10.009
Staphylococcus aureus Staphylococcus aureus Ratio 16.0 None 10.1016/j.ejmech.2021.113723
Staphylococcus aureus Staphylococcus aureus Ratio 32.0 None 10.1016/j.ejmech.2021.113723
Staphylococcus epidermidis Staphylococcus epidermidis Activity nan None 10.1016/j.bmc.2011.11.052
Staphylococcus epidermidis Staphylococcus epidermidis EC50 4400.0 nM 10.1016/j.bmc.2011.11.052
Staphylococcus epidermidis Staphylococcus epidermidis MBC 34.0 uM 10.1016/j.bmc.2011.11.052
Staphylococcus epidermidis Staphylococcus epidermidis MIC 8.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Staphylococcus epidermidis Staphylococcus epidermidis MIC 64.0 ug.mL-1 10.1016/j.bmcl.2017.06.005
Staphylococcus epidermidis Staphylococcus epidermidis MIC 8500.0 nM 10.1016/j.bmc.2011.11.052
Streptococcus mutans Streptococcus mutans MIC 15.0 ug.mL-1 10.1021/np960451q
Streptococcus mutans Streptococcus mutans MIC 15.0 ug.mL-1 10.1021/np970524l
Streptococcus pyogenes Streptococcus pyogenes MIC 2.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1016/j.bmcl.2017.06.005
Trypanosoma brucei 6-phospho-1-fructokinase Potency 47.8 nM None
None ADMET Log K 2.97 None 10.1021/jm00141a019
None ADMET Log K 3.33 None 10.1021/jm00141a019
None ADMET Log K 3.77 None 10.1021/jm00141a019
None ADMET Log K 4.01 None 10.1021/jm00141a019
None ADMET Log K 4.64 None 10.1021/jm00141a019
None ADMET Log K 4.79 None 10.1021/jm00141a019
None NON-PROTEIN TARGET Activity nan None 10.1039/C3MD00149K
None NON-PROTEIN TARGET EC50 890.0 nM 10.1039/C3MD00149K
None NON-PROTEIN TARGET EC50 930.0 nM 10.1039/C3MD00149K
None NON-PROTEIN TARGET EC50 1000.0 nM 10.1039/C3MD00149K
None NON-PROTEIN TARGET GI 88.5 % 10.1016/j.bmcl.2016.11.031
None NON-PROTEIN TARGET GI 92.3 % 10.1016/j.bmcl.2016.11.031
None NON-PROTEIN TARGET IC50 530.0 nM 10.1016/j.bmcl.2016.11.031
None NON-PROTEIN TARGET IC50 1510.0 nM 10.1016/j.bmcl.2016.11.031
None No relevant target Activity nan None 10.1021/acs.jnatprod.7b00112
None No relevant target EC50 513000.0 nM 10.1039/C3MD00149K
None Unchecked Ac50 17.78 uM None
None Unchecked AC50 17782.8 nM None
None Unchecked Activity nan None 10.1016/j.bmc.2020.115732
None Unchecked FC 18.0 None 10.1016/j.ejmech.2017.06.047
None Unchecked FC 35.0 None 10.1016/j.ejmech.2017.06.047
None Unchecked GI nan None 10.1021/acs.jnatprod.7b00112
None Unchecked IC50 264.6 nM None
None Unchecked IC50 316.1 nM None
None Unchecked IC50 349.8 nM None
None Unchecked IC50 378.9 nM None
None Unchecked IC50 525.3 nM None
None Unchecked IC50 537.2 nM None
None Unchecked IC50 575.5 nM None
None Unchecked IC50 970.46 nM None
None Unchecked IC50 10000.0 nM 10.1016/j.ejmech.2020.112855
None Unchecked IC50 40000.0 nM None
None Unchecked IC50 51832.0 nM None
None Unchecked IC50 121805.0 nM None
None Unchecked Inhibition nan % 10.1021/acs.jnatprod.7b00112
None Unchecked MIC 8.0 ug.mL-1 10.1016/j.bmcl.2017.06.005
None Unchecked MIC 128.0 ug.mL-1 10.1016/j.bmcl.2017.06.005
None Unchecked Potency 1299.5 nM None
None Unchecked Potency 1834.9 nM None
None Unchecked Potency 1995.3 nM None
None Unchecked Potency 2511.9 nM None
None Unchecked Potency 3162.3 nM None
None Unchecked Potency 3219.7 nM None
None Unchecked Potency 5011.9 nM None
None Unchecked Potency 7307.8 nM None
None Unchecked Potency 8912.5 nM None
None Unchecked Potency 14125.4 nM None
None Unchecked Potency 25118.9 nM None
None Unchecked Potency 31622.8 nM None
None Unchecked Ratio 4.0 None 10.1016/j.bmc.2011.11.052
None Unchecked Selectivity Index 5.8 None 10.1016/j.ejmech.2020.112415

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT010585 CN1Cc2c(ccc3c2OCO3)-c2ccc3cc4c(cc3c21)OCO4>>C[n+]1cc2c3c(ccc2c2ccc4cc5c(cc4c21)OCO5)OCO3 1.5.3.12-RXN
AKRT014789 C[n+]1cc2c3c(ccc2c2ccc4cc5c(cc4c21)OCO5)OCO3>>CN1Cc2c(ccc3c2OCO3)-c2ccc3cc4c(cc3c21)OCO4 RXN-9276