4-chloro-1-methyl-3-nitro-1,2-dihydroquinolin-2-one
AlkaPlorer ID: AK435980
Synonym: None
IUPAC Name: 4-chloro-1-methyl-3-nitroquinolin-2-one
Structure
SMILES: CN1C(=O)C([N+](=O)[O-])=C(Cl)C2=CC=CC=C21
InChI: InChI=1S/C10H7ClN2O3/c1-12-7-5-3-2-4-6(7)8(11)9(10(12)14)13(15)16/h2-5H,1H3
InChIKey: KPDOVJBEKCRATD-UHFFFAOYSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|
Properties Information
Molecule Weight: 238.63
TPSA？: 65.14
MolLogP？: 2.1001
Number of H-Donors: 0
Number of H-Acceptors: 4
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Cricetulus griseus | CHO | IC50 | 1182.0 | nM | None |
| Escherichia coli K-12 | Beta-lactamase AmpC | Potency | 28183.8 | nM | None |
| Homo sapiens | Aldehyde dehydrogenase 1A1 | Potency | 17782.8 | nM | None |
| Homo sapiens | Alpha-synuclein | Potency | 5623.4 | nM | None |
| Homo sapiens | Ataxin-2 | Potency | 29934.9 | nM | None |
| Homo sapiens | ATPase family AAA domain-containing protein 5 | Potency | 18348.9 | nM | None |
| Homo sapiens | ATPase family AAA domain-containing protein 5 | Potency | 29081.0 | nM | None |
| Homo sapiens | Bcl-2-like protein 11/Bcl-2-related protein A1 | AC10 | 1.106 | uM | None |
| Homo sapiens | Breast cancer type 1 susceptibility protein | Potency | 35481.3 | nM | None |
| Homo sapiens | DNA dC->dU-editing enzyme APOBEC-3G | Potency | 5623.4 | nM | None |
| Homo sapiens | DNA polymerase iota | Potency | 100000.0 | nM | None |
| Homo sapiens | Geminin | Potency | 3662.6 | nM | None |
| Homo sapiens | Geminin | Potency | 16360.1 | nM | None |
| Homo sapiens | Glycoprotein hormones alpha chain | Potency | 3548.1 | nM | None |
| Homo sapiens | GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 | Potency | 10322.5 | nM | None |
| Homo sapiens | Guanine nucleotide-binding protein G(s), subunit alpha | Potency | 28183.8 | nM | None |
| Homo sapiens | HEK293 | Potency | 35481.3 | nM | None |
| Homo sapiens | HepG2 | Potency | 22387.2 | nM | None |
| Homo sapiens | Isocitrate dehydrogenase [NADP] cytoplasmic | Potency | 5804.8 | nM | None |
| Homo sapiens | Luteinizing hormone/Choriogonadotropin receptor | Potency | 75686.3 | nM | None |
| Homo sapiens | Microtubule-associated protein tau | Potency | 11220.2 | nM | None |
| Homo sapiens | Mothers against decapentaplegic homolog 3 | Potency | 10000.0 | nM | None |
| Homo sapiens | Neuropeptide S receptor | Potency | 10000.0 | nM | None |
| Homo sapiens | Niemann-Pick C1 protein | Potency | 3548.1 | nM | None |
| Homo sapiens | Nuclear factor erythroid 2-related factor 2 | Potency | 29092.9 | nM | None |
| Homo sapiens | Paired box protein Pax-8 | AC50 | 6650.0 | nM | None |
| Homo sapiens | Prelamin-A/C | Potency | 17782.8 | nM | None |
| Homo sapiens | Ras-related protein Rab-9A | Potency | 6309.6 | nM | None |
| Homo sapiens | Serine/threonine-protein kinase PLK1 | Potency | 4744.4 | nM | None |
| Homo sapiens | Survival motor neuron protein | Potency | 35481.3 | nM | None |
| Homo sapiens | Thyroid stimulating hormone receptor | Potency | 30131.3 | nM | None |
| Homo sapiens | Toll-like receptor 9 | IC50 | 3656.0 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 2592.9 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 4610.9 | nM | None |
| Homo sapiens | Vitamin D receptor | Potency | 17782.8 | nM | None |
| Homo sapiens | X-box-binding protein 1 | IC50 | 5420.0 | nM | None |
| Influenza A virus | Nonstructural protein 1 | Potency | 5011.9 | nM | None |
| Mus musculus | DNA damage-inducible transcript 3 protein | IC50 | 3340.0 | nM | None |
| Mus musculus | Heat shock factor protein 1 | AC50 | 11404.0 | nM | None |
| Mus musculus | Heat shock factor protein 1 | AC50 | 14160.0 | nM | None |
| Mus musculus | Heat shock factor protein 1 | AC50 | 16930.0 | nM | None |
| Mus musculus | Heat shock factor protein 1 | EC50 | 4301.0 | nM | None |
| Mus musculus | MEF | AC10 | 0.632 | uM | None |
| Mus musculus | MEF | AC10 | 0.716 | uM | None |
| Mus musculus | Nuclear receptor ROR-gamma | Potency | 10000.0 | nM | None |
| Mus musculus | Nuclear receptor ROR-gamma | Potency | 12589.3 | nM | None |
| Mycobacterium tuberculosis | Protein RecA | EC50 | 4250.0 | nM | None |
| Mycobacterium tuberculosis | Replicative DNA helicase | AC50 | 5184.0 | nM | None |
| Mycobacterium tuberculosis | Replicative DNA helicase | AC50 | 380000.0 | nM | None |
| Pseudomonas aeruginosa | Beta Lactamase | IC50 | 17802.0 | nM | None |
| Rattus norvegicus | Inositol monophosphatase 1 | Potency | 11220.2 | nM | None |
| Rattus norvegicus | Thioredoxin reductase 1, cytoplasmic | Potency | 2238.7 | nM | None |
| Schistosoma mansoni | Thioredoxin glutathione reductase | Potency | 446.7 | nM | None |
| None | Unchecked | EC50 | 1869.0 | nM | None |
| None | Unchecked | EC50 | 3972.0 | nM | None |
| None | Unchecked | Potency | 2818.4 | nM | None |
| None | Unchecked | Potency | 3662.6 | nM | None |
| None | Unchecked | Potency | 5623.4 | nM | None |
| None | Unchecked | Potency | 5804.8 | nM | None |
| None | Unchecked | Potency | 7943.3 | nM | None |
| None | Unchecked | Potency | 14125.4 | nM | None |
| None | Unchecked | Potency | 20596.2 | nM | None |