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name Structure Reference Source Properties Activities Metabolism

3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine

AlkaPlorer ID: AK437777

Synonym: None

IUPAC Name: 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

Structure

SMILES: CC(OC1=CC(C2=CN(C3CCNCC3)N=C2)=CN=C1N)C1=C(Cl)C=CC(F)=C1Cl

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InChI: InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)

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InChIKey: KTEIFNKAUNYNJU-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 450.34500000000014

TPSA？: 77.99

MolLogP？: 5.037700000000004

Number of H-Donors: 2

Number of H-Acceptors: 6

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Ki 3981.07 nM None
Homo sapiens Activin receptor type-1 Ki 158.49 nM None
Homo sapiens Activin receptor type-1 Ki 1258.93 nM None
Homo sapiens ALK tyrosine kinase receptor IC50 800.0 nM 10.1016/j.ejmech.2022.114488
Homo sapiens ALK tyrosine kinase receptor IC50 10000.0 nM 10.1016/j.ejmech.2022.114488
Homo sapiens ALK tyrosine kinase receptor Inhibition 100.0 % 10.1016/j.ejmech.2022.114488
Homo sapiens ALK tyrosine kinase receptor Inhibition nan % 10.1016/j.ejmech.2022.114488
Homo sapiens ALK tyrosine kinase receptor Ki 3.162 nM None
Homo sapiens ALK tyrosine kinase receptor Ki 12.59 nM None
Homo sapiens ALK tyrosine kinase receptor Ki 63.1 nM None
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Ki 794.33 nM None
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Ki 1584.89 nM None
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Ki 3162.28 nM None
Homo sapiens BR serine/threonine-protein kinase 1 Ki 10000.0 nM None
Homo sapiens CaM kinase I alpha Ki 5011.87 nM None
Homo sapiens CaM kinase I delta Ki 2511.89 nM None
Homo sapiens CaM kinase II alpha Ki 7943.28 nM None
Homo sapiens CaM kinase II beta Ki 7943.28 nM None
Homo sapiens CaM kinase II delta Ki 3162.28 nM None
Homo sapiens CaM kinase II delta Ki 6309.57 nM None
Homo sapiens CaM kinase II gamma Ki 6309.57 nM None
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Ki 1258.93 nM None
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Ki 1584.89 nM None
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Ki 7943.28 nM None
Homo sapiens Casein kinase I alpha Ki 3981.07 nM None
Homo sapiens Casein kinase I alpha Ki 6309.57 nM None
Homo sapiens Casein kinase I delta Ki 7943.28 nM None
Homo sapiens Casein kinase I gamma 1 Ki 6309.57 nM None
Homo sapiens Casein kinase I gamma 2 Ki 7943.28 nM None
Homo sapiens Casein kinase II alpha Ki 6309.57 nM None
Homo sapiens Casein kinase I isoform gamma-3 Ki 6309.57 nM None
Homo sapiens Cell division cycle 7-related protein kinase Ki 794.33 nM None
Homo sapiens Cell division cycle 7-related protein kinase Ki 1258.93 nM None
Homo sapiens Cell division protein kinase 8 Ki 3981.07 nM None
Homo sapiens cGMP-dependent protein kinase 1 beta Ki 1995.26 nM None
Homo sapiens cGMP-dependent protein kinase 2 Ki 1584.89 nM None
Homo sapiens c-Jun N-terminal kinase 1 Ki 3162.28 nM None
Homo sapiens c-Jun N-terminal kinase 1 Ki 5011.87 nM None
Homo sapiens c-Jun N-terminal kinase 2 Ki 3981.07 nM None
Homo sapiens Cyclin-dependent kinase 1 Ki 5011.87 nM None
Homo sapiens Cyclin-dependent kinase 2 Ki 3162.28 nM None
Homo sapiens Cyclin-dependent kinase 2 Ki 6309.57 nM None
Homo sapiens Cyclin-dependent kinase 5 Ki 1584.89 nM None
Homo sapiens Cyclin-dependent kinase 5 Ki 3162.28 nM None
Homo sapiens Cyclin-dependent kinase 5 Ki 10000.0 nM None
Homo sapiens Cyclin-dependent kinase 7 Ki 630.96 nM None
Homo sapiens Cyclin-dependent kinase 7 Ki 1584.89 nM None
Homo sapiens Cyclin-dependent kinase 7 Ki 3981.07 nM None
Homo sapiens Cyclin-dependent kinase 9 Ki 1584.89 nM None
Homo sapiens Death-associated protein kinase 3 Ki 1258.93 nM None
Homo sapiens Death-associated protein kinase 3 Ki 5011.87 nM None
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Ki 3162.28 nM None
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Ki 3981.07 nM None
Homo sapiens Dual specificity protein kinase CLK2 Ki 3981.07 nM None
Homo sapiens Dual specificity protein kinase CLK2 Ki 7943.28 nM None
Homo sapiens Dual specificity protein kinase CLK4 Ki 1995.26 nM None
Homo sapiens Dual specificity protein kinase CLK4 Ki 2511.89 nM None
Homo sapiens Dual specificity protein kinase CLK4 Ki 10000.0 nM None
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Ki 1995.26 nM None
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Ki 6309.57 nM None
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Ki 2511.89 nM None
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 Ki 6309.57 nM None
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 4 Ki 7943.28 nM None
Homo sapiens Ephrin type-A receptor 2 Ki 125.89 nM None
Homo sapiens Ephrin type-A receptor 2 Ki 251.19 nM None
Homo sapiens Epidermal growth factor receptor erbB1 Ki 1995.26 nM None
Homo sapiens Fibroblast Growth Rate -0.95 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate -0.94 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate -0.67 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate -0.64 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate -0.52 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate -0.44 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate -0.22 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast growth factor receptor 1 Ki 2511.89 nM None
Homo sapiens Fibroblast growth factor receptor 1 Ki 3162.28 nM None
Homo sapiens Fibroblast growth factor receptor 1 Ki 3981.07 nM None
Homo sapiens Fibroblast growth factor receptor 3 Ki 1584.89 nM None
Homo sapiens Fibroblast growth factor receptor 3 Ki 1995.26 nM None
Homo sapiens Focal adhesion kinase 1 Ki 63.1 nM None
Homo sapiens Focal adhesion kinase 1 Ki 398.11 nM None
Homo sapiens Focal adhesion kinase 1 Ki 794.33 nM None
Homo sapiens Glycogen synthase kinase-3 alpha Ki 3981.07 nM None
Homo sapiens Glycogen synthase kinase-3 alpha Ki 7943.28 nM None
Homo sapiens Glycogen synthase kinase-3 beta Ki 3981.07 nM None
Homo sapiens Glycogen synthase kinase-3 beta Ki 6309.57 nM None
Homo sapiens G protein-coupled receptor kinase 5 Ki 3981.07 nM None
Homo sapiens HEK-293T Growth Rate -0.85 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate -0.78 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate -0.51 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate -0.49 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate -0.35 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate -0.28 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate -0.18 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate -0.11 None 10.6019/CHEMBL5303304
Homo sapiens HEL IC50 6575.0 nM 10.1016/j.bmcl.2019.04.011
Homo sapiens Hepatocyte growth factor receptor IC50 18.3 nM 10.1021/jm2007613
Homo sapiens Hepatocyte growth factor receptor Ki 0.631 nM None
Homo sapiens Hepatocyte growth factor receptor Ki 10.0 nM None
Homo sapiens Hepatocyte growth factor receptor Ki 15.85 nM None
Homo sapiens Hepatocyte growth factor receptor Ki 19.3 nM 10.1021/jm2007613
Homo sapiens Homeodomain-interacting protein kinase 2 Ki 3162.28 nM None
Homo sapiens Homeodomain-interacting protein kinase 2 Ki 3981.07 nM None
Homo sapiens Homeodomain-interacting protein kinase 4 Ki 7943.28 nM None
Homo sapiens Inhibitor of nuclear factor kappa B kinase epsilon subunit Ki 501.19 nM None
Homo sapiens Inhibitor of nuclear factor kappa B kinase epsilon subunit Ki 3162.28 nM None
Homo sapiens Insulin-like growth factor I receptor Ki 199.53 nM None
Homo sapiens Insulin-like growth factor I receptor Ki 251.19 nM None
Homo sapiens Insulin-like growth factor I receptor Ki 2511.89 nM None
Homo sapiens Insulin receptor Ki 398.11 nM None
Homo sapiens Interleukin-1 receptor-associated kinase 1 Ki 199.53 nM None
Homo sapiens Interleukin-1 receptor-associated kinase 4 Ki 794.33 nM None
Homo sapiens Interleukin-1 receptor-associated kinase 4 Ki 5011.87 nM None
Homo sapiens Leucine-rich repeat serine/threonine-protein kinase 2 Ki 1995.26 nM None
Homo sapiens Leucine-rich repeat serine/threonine-protein kinase 2 Ki 2511.89 nM None
Homo sapiens Leukocyte tyrosine kinase receptor Ki 2.512 nM None
Homo sapiens Leukocyte tyrosine kinase receptor Ki 50.12 nM None
Homo sapiens LIM domain kinase 1 Ki 100.0 nM None
Homo sapiens Liver microsomes Stability 44.6 % 10.1021/jm2007613
Homo sapiens Macrophage colony stimulating factor receptor Ki 501.19 nM None
Homo sapiens Macrophage colony stimulating factor receptor Ki 2511.89 nM None
Homo sapiens Macrophage-stimulating protein receptor Ki 316.23 nM None
Homo sapiens Macrophage-stimulating protein receptor Ki 3162.28 nM None
Homo sapiens MAP kinase-activated protein kinase 2 Ki 7943.28 nM None
Homo sapiens MAP kinase-activated protein kinase 3 Ki 10000.0 nM None
Homo sapiens MAP kinase-activated protein kinase 5 Ki 1584.89 nM None
Homo sapiens MAP kinase ERK2 Ki 7943.28 nM None
Homo sapiens MAP kinase p38 alpha Ki 3981.07 nM None
Homo sapiens MAP kinase p38 delta Ki 7943.28 nM None
Homo sapiens MAP kinase p38 gamma Ki 6309.57 nM None
Homo sapiens MAP kinase signal-integrating kinase 2 Ki 10000.0 nM None
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Ki 630.96 nM None
Homo sapiens Maternal embryonic leucine zipper kinase Ki 1584.89 nM None
Homo sapiens Misshapen-like kinase 1 Ki 1258.93 nM None
Homo sapiens Misshapen-like kinase 1 Ki 3162.28 nM None
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Ki 251.19 nM None
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Ki 316.23 nM None
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Ki 2511.89 nM None
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Ki 3981.07 nM None
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Ki 5011.87 nM None
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Ki 10000.0 nM None
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Ki 39.81 nM None
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Ki 50.12 nM None
Homo sapiens Mixed lineage kinase 7 Ki 7943.28 nM None
Homo sapiens Nerve growth factor receptor Trk-A Ki 501.19 nM None
Homo sapiens Nerve growth factor receptor Trk-A Ki 1258.93 nM None
Homo sapiens Nerve growth factor receptor Trk-A Ki 3162.28 nM None
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Ki 158.49 nM None
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Ki 1000.0 nM None
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Ki 2511.89 nM None
Homo sapiens NT-3 growth factor receptor Ki 5.012 nM None
Homo sapiens NT-3 growth factor receptor Ki 316.23 nM None
Homo sapiens NT-3 growth factor receptor Ki 3162.28 nM None
Homo sapiens PAS domain-containing serine/threonine-protein kinase Ki 1584.89 nM None
Homo sapiens PDZ-binding kinase Ki 10000.0 nM None
Homo sapiens Phosphorylase kinase gamma subunit 2 Ki 3162.28 nM None
Homo sapiens Platelet-derived growth factor receptor alpha Ki 2511.89 nM None
Homo sapiens Platelet-derived growth factor receptor beta Ki 1995.26 nM None
Homo sapiens Protein kinase C delta Ki 7943.28 nM None
Homo sapiens Protein kinase C gamma Ki 7943.28 nM None
Homo sapiens Protein kinase C iota Ki 5011.87 nM None
Homo sapiens Protein kinase C nu Ki 199.53 nM None
Homo sapiens Protein kinase C nu Ki 630.96 nM None
Homo sapiens Protein kinase C nu Ki 3981.07 nM None
Homo sapiens Protein kinase C theta Ki 2511.89 nM None
Homo sapiens Protein kinase C zeta Ki 7943.28 nM None
Homo sapiens Protein kinase N2 Ki 1995.26 nM None
Homo sapiens Protein kinase N2 Ki 2511.89 nM None
Homo sapiens Protein tyrosine kinase 2 beta Ki 158.49 nM None
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Ki 1.585 nM None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki 1584.89 nM None
Homo sapiens Rho-associated protein kinase 1 Ki 1000.0 nM None
Homo sapiens Rho-associated protein kinase 1 Ki 3981.07 nM None
Homo sapiens Rho-associated protein kinase 1 Ki 10000.0 nM None
Homo sapiens Rho-associated protein kinase 2 Ki 1995.26 nM None
Homo sapiens Rho-associated protein kinase 2 Ki 7943.28 nM None
Homo sapiens Ribosomal protein S6 kinase 1 Ki 1584.89 nM None
Homo sapiens Ribosomal protein S6 kinase alpha 3 Ki 1995.26 nM None
Homo sapiens Ribosomal protein S6 kinase alpha 3 Ki 3981.07 nM None
Homo sapiens Ribosomal protein S6 kinase alpha 3 Ki 7943.28 nM None
Homo sapiens Ribosomal protein S6 kinase alpha 5 Ki 1995.26 nM None
Homo sapiens Serine/threonine-protein kinase 17A Ki 3162.28 nM None
Homo sapiens Serine/threonine-protein kinase 17A Ki 3981.07 nM None
Homo sapiens Serine/threonine-protein kinase 2 Ki 31.62 nM None
Homo sapiens Serine/threonine-protein kinase 2 Ki 39.81 nM None
Homo sapiens Serine/threonine-protein kinase AKT Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase AKT2 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase AKT3 Ki 10000.0 nM None
Homo sapiens Serine/threonine-protein kinase Aurora-A Ki 79.43 nM None
Homo sapiens Serine/threonine-protein kinase Aurora-A Ki 316.23 nM None
Homo sapiens Serine/threonine-protein kinase Aurora-A Ki 1584.89 nM None
Homo sapiens Serine/threonine-protein kinase Aurora-B Ki 39.81 nM None
Homo sapiens Serine/threonine-protein kinase Aurora-B Ki 50.12 nM None
Homo sapiens Serine/threonine-protein kinase Aurora-B Ki 316.23 nM None
Homo sapiens Serine/threonine-protein kinase Chk1 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase Chk2 Ki 1584.89 nM None
Homo sapiens Serine/threonine-protein kinase c-TAK1 Ki 5011.87 nM None
Homo sapiens Serine/threonine-protein kinase D2 Ki 1584.89 nM None
Homo sapiens Serine/threonine-protein kinase DCLK1 Ki 1584.89 nM None
Homo sapiens Serine/threonine-protein kinase MRCK-A Ki 10000.0 nM None
Homo sapiens Serine/threonine-protein kinase MST2 Ki 794.33 nM None
Homo sapiens Serine/threonine-protein kinase MST2 Ki 3162.28 nM None
Homo sapiens Serine/threonine-protein kinase NEK2 Ki 10000.0 nM None
Homo sapiens Serine/threonine-protein kinase Nek4 Ki 3162.28 nM None
Homo sapiens Serine/threonine-protein kinase PAK 1 Ki 10000.0 nM None
Homo sapiens Serine/threonine-protein kinase PAK 4 Ki 3981.07 nM None
Homo sapiens Serine/threonine-protein kinase PAK 4 Ki 5011.87 nM None
Homo sapiens Serine/threonine-protein kinase PIM1 Ki 6309.57 nM None
Homo sapiens Serine/threonine-protein kinase PIM1 Ki 10000.0 nM None
Homo sapiens Serine/threonine-protein kinase PIM2 Ki 1584.89 nM None
Homo sapiens Serine/threonine-protein kinase PIM3 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase PLK1 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase PLK3 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase PLK4 Ki 39.81 nM None
Homo sapiens Serine/threonine-protein kinase PLK4 Ki 501.19 nM None
Homo sapiens Serine/threonine-protein kinase PRKX Ki 1584.89 nM None
Homo sapiens Serine/threonine-protein kinase PRKX Ki 3162.28 nM None
Homo sapiens Serine/threonine-protein kinase Sgk2 Ki 10000.0 nM None
Homo sapiens Serine/threonine-protein kinase SRPK1 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase TAO1 Ki 100.0 nM None
Homo sapiens Serine/threonine-protein kinase TAO1 Ki 199.53 nM None
Homo sapiens Serine/threonine-protein kinase TAO1 Ki 2511.89 nM None
Homo sapiens Serine/threonine-protein kinase TBK1 Ki 1584.89 nM None
Homo sapiens Serine/threonine-protein kinase TBK1 Ki 1995.26 nM None
Homo sapiens Serine/threonine-protein kinase TBK1 Ki 3162.28 nM None
Homo sapiens Serine/threonine-protein kinase WEE1 Ki 2511.89 nM None
Homo sapiens Stem cell growth factor receptor Ki 1258.93 nM None
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Ki 1584.89 nM None
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Ki 630.96 nM None
Homo sapiens Tyrosine kinase non-receptor protein 2 Ki 398.11 nM None
Homo sapiens Tyrosine kinase non-receptor protein 2 Ki 3981.07 nM None
Homo sapiens Tyrosine-protein kinase ABL Ki 79.43 nM None
Homo sapiens Tyrosine-protein kinase ABL Ki 630.96 nM None
Homo sapiens Tyrosine-protein kinase ABL Ki 1584.89 nM None
Homo sapiens Tyrosine-protein kinase BLK Ki 630.96 nM None
Homo sapiens Tyrosine-protein kinase BLK Ki 1000.0 nM None
Homo sapiens Tyrosine-protein kinase BRK Ki 2511.89 nM None
Homo sapiens Tyrosine-protein kinase BTK Ki 1258.93 nM None
Homo sapiens Tyrosine-protein kinase BTK Ki 5011.87 nM None
Homo sapiens Tyrosine-protein kinase BTK Ki 6309.57 nM None
Homo sapiens Tyrosine-protein kinase CTK Ki 1995.26 nM None
Homo sapiens Tyrosine-protein kinase FER Ki 31.62 nM None
Homo sapiens Tyrosine-protein kinase FER Ki 39.81 nM None
Homo sapiens Tyrosine-protein kinase FES Ki 50.12 nM None
Homo sapiens Tyrosine-protein kinase FRK Ki 199.53 nM None
Homo sapiens Tyrosine-protein kinase FRK Ki 316.23 nM None
Homo sapiens Tyrosine-protein kinase FYN Ki 794.33 nM None
Homo sapiens Tyrosine-protein kinase FYN Ki 3162.28 nM None
Homo sapiens Tyrosine-protein kinase FYN Ki 6309.57 nM None
Homo sapiens Tyrosine-protein kinase ITK/TSK Ki 251.19 nM None
Homo sapiens Tyrosine-protein kinase JAK2 IC50 92.0 nM 10.1016/j.bmcl.2019.04.011
Homo sapiens Tyrosine-protein kinase JAK2 Ki 100.0 nM None
Homo sapiens Tyrosine-protein kinase JAK2 Ki 794.33 nM None
Homo sapiens Tyrosine-protein kinase JAK3 Ki 630.96 nM None
Homo sapiens Tyrosine-protein kinase JAK3 Ki 1995.26 nM None
Homo sapiens Tyrosine-protein kinase JAK3 Ki 5011.87 nM None
Homo sapiens Tyrosine-protein kinase LCK Ki 50.12 nM None
Homo sapiens Tyrosine-protein kinase LCK Ki 100.0 nM None
Homo sapiens Tyrosine-protein kinase LCK Ki 1000.0 nM None
Homo sapiens Tyrosine-protein kinase Lyn Ki 1258.93 nM None
Homo sapiens Tyrosine-protein kinase Lyn Ki 1584.89 nM None
Homo sapiens Tyrosine-protein kinase receptor FLT3 Ki 1258.93 nM None
Homo sapiens Tyrosine-protein kinase receptor FLT3 Ki 1584.89 nM None
Homo sapiens Tyrosine-protein kinase receptor FLT3 Ki 3162.28 nM None
Homo sapiens Tyrosine-protein kinase receptor RET Ki 1000.0 nM None
Homo sapiens Tyrosine-protein kinase receptor RET Ki 1258.93 nM None
Homo sapiens Tyrosine-protein kinase receptor RET Ki 3162.28 nM None
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Ki 50.12 nM None
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Ki 251.19 nM None
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Ki 1258.93 nM None
Homo sapiens Tyrosine-protein kinase receptor UFO Ki 5.012 nM None
Homo sapiens Tyrosine-protein kinase receptor UFO Ki 10.0 nM None
Homo sapiens Tyrosine-protein kinase SRC Ki 316.23 nM None
Homo sapiens Tyrosine-protein kinase SRC Ki 1995.26 nM None
Homo sapiens Tyrosine-protein kinase Srms Ki 1584.89 nM None
Homo sapiens Tyrosine-protein kinase SYK Ki 794.33 nM None
Homo sapiens Tyrosine-protein kinase SYK Ki 1000.0 nM None
Homo sapiens Tyrosine-protein kinase TYK2 Ki 1995.26 nM None
Homo sapiens Tyrosine-protein kinase YES Potency 688.4 nM None
Homo sapiens U2OS Growth Rate -1.0 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.39 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.4 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.45 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.5 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.53 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.65 None 10.6019/CHEMBL5303304
Homo sapiens Vascular endothelial growth factor receptor 1 Ki 125.89 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki 2511.89 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki 3981.07 nM None
Homo sapiens Vascular endothelial growth factor receptor 2 Ki 1584.89 nM None
Homo sapiens Vascular endothelial growth factor receptor 2 Ki 2511.89 nM None
Homo sapiens Vascular endothelial growth factor receptor 2 Ki 6309.57 nM None
Homo sapiens Vascular endothelial growth factor receptor 3 Ki 1584.89 nM None
Homo sapiens Vascular endothelial growth factor receptor 3 Ki 3162.28 nM None
None Unchecked Potency 1481.8 nM None
None Unchecked Potency 2635.1 nM None
None Unchecked Potency 7426.6 nM None
None Unchecked Potency 16626.1 nM None
None Unchecked Potency 16771.6 nM None
None Unchecked Potency 18654.8 nM None
None Unchecked Potency 26350.6 nM None
None Unchecked Potency 29565.9 nM None

Metabolism Information