N-[(8-hydroxy-7-quinolyl)-(4-methoxyphenyl)methyl]pentanamide
AlkaPlorer ID: AK445399
Synonym: None
IUPAC Name: N-[(8-hydroxyquinolin-7-yl)-(4-methoxyphenyl)methyl]pentanamide
Structure
SMILES: CCCCC(=O)NC(C1=CC=C(OC)C=C1)C1=CC=C2C=CC=NC2=C1O
InChI: InChI=1S/C22H24N2O3/c1-3-4-7-19(25)24-20(16-8-11-17(27-2)12-9-16)18-13-10-15-6-5-14-23-21(15)22(18)26/h5-6,8-14,20,26H,3-4,7H2,1-2H3,(H,24,25)
InChIKey: LKSBKMAJHSOYQS-UHFFFAOYSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|
Properties Information
Molecule Weight: 364.4450000000001
TPSA？: 71.45
MolLogP？: 4.344800000000004
Number of H-Donors: 2
Number of H-Acceptors: 4
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | Ataxin-2 | Potency | 794.3 | nM | None |
| Homo sapiens | Breast cancer type 1 susceptibility protein | Potency | 1778.3 | nM | None |
| Homo sapiens | DNA dC->dU-editing enzyme APOBEC-3F | Potency | 35481.3 | nM | None |
| Homo sapiens | Guanine nucleotide-binding protein G(s), subunit alpha | Potency | 50118.7 | nM | None |
| Homo sapiens | HEK293 | AC50 | 15750.0 | nM | None |
| Homo sapiens | HEK293 | IC50 | 5250.0 | nM | None |
| Homo sapiens | HEK293 | IC50 | 21720.0 | nM | None |
| Homo sapiens | HepG2 | Potency | 3981.1 | nM | None |
| Homo sapiens | Isocitrate dehydrogenase [NADP] cytoplasmic | Potency | 18356.4 | nM | None |
| Homo sapiens | Jurkat | IC50 | 3220.0 | nM | None |
| Homo sapiens | Mothers against decapentaplegic homolog 3 | Potency | 3981.1 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 5804.8 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 9200.0 | nM | None |
| Human herpesvirus 4 (strain B95-8) | Latent membrane protein 1 | AC50 | 11630.0 | nM | None |
| Human herpesvirus 4 (strain B95-8) | Latent membrane protein 1 | AC50 | 16180.0 | nM | None |
| Human herpesvirus 4 (strain B95-8) | Latent membrane protein 1 | AC50 | 17653.0 | nM | None |
| None | Unchecked | AC50 | 2280.0 | nM | None |
| None | Unchecked | AC50 | 5140.0 | nM | None |
| None | Unchecked | AC50 | 8800.0 | nM | None |
| None | Unchecked | IC50 | 79000.0 | nM | None |
| None | Unchecked | Potency | 794.3 | nM | None |
| None | Unchecked | Potency | 10000.0 | nM | None |
| None | Unchecked | Potency | 12589.3 | nM | None |
| None | Unchecked | Potency | 23109.3 | nM | None |