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Chelerythrine

AlkaPlorer ID: AK445615

Synonym: None

IUPAC Name: 1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium

Structure

SMILES: COC1=CC=C2C(=C1OC)C=[N+](C)C1=C3C=C4OCOC4=CC3=CC=C21

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InChI: InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1

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InChIKey: LLEJIEBFSOEYIV-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Argemone mexicana Argemone Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 348.3780000000001

TPSA？: 40.8

MolLogP？: 3.7166000000000015

Number of H-Donors: 0

Number of H-Acceptors: 4

RingCount: 5

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus anthracis Anthrax lethal factor Potency 25118.9 nM None
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 25118.9 nM None
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 50118.7 nM None
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 56234.1 nM None
Bacillus subtilis (strain 168) DNA polymerase III Potency 26679.5 nM None
Bos taurus Calf thymus DNA Activity nan None 10.1021/acs.jnatprod.7b00350
Enterococcus faecalis Enterococcus faecalis MIC 32.0 ug.mL-1 10.1016/j.ejmech.2012.12.027
Enterococcus faecalis Enterococcus faecalis MIC=>90 32.0 ug ml-1 10.1016/j.bmcl.2013.02.016
Enterococcus faecalis Enterococcus faecalis MIC90 32.0 ug.mL-1 10.1016/j.bmc.2012.10.009
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Potency 5000.0 nM None
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Potency 17740.7 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 19952.6 nM None
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens 78 kDa glucose-regulated protein Potency 20749.1 nM None
Homo sapiens A-431 Inhibition 100.0 % 10.1016/j.bmc.2016.04.059
Homo sapiens A549 IC50 7730.0 nM 10.1016/j.bmc.2016.07.065
Homo sapiens Acetylcholinesterase IC50 1450.0 nM 10.1016/j.ejmech.2020.112415
Homo sapiens Acetylcholinesterase Inhibition 76.9 % 10.1016/j.ejmech.2020.112415
Homo sapiens Activin receptor type-1B Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Activin receptor type-1B Residual Activity 132.0 % 10.1042/bj20121418
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 15848.9 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 22387.2 nM None
Homo sapiens ALK tyrosine kinase receptor Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens ALK tyrosine kinase receptor Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 66.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Arachidonate 12-lipoxygenase Potency 12589.3 nM None
Homo sapiens Arachidonate 15-lipoxygenase Potency 19952.6 nM None
Homo sapiens Arachidonate 15-lipoxygenase, type II Potency 12589.3 nM None
Homo sapiens Arachidonate 15-lipoxygenase, type II Potency 15848.9 nM None
Homo sapiens Ataxin-2 Potency 5623.4 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 16353.5 nM None
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 47.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 48.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 67.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Butyrylcholinesterase IC50 8580.0 nM 10.1016/j.ejmech.2020.112415
Homo sapiens CaM kinase I alpha Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I alpha Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I delta Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I delta Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Residual Activity 126.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens CDK3/cyclin E Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens CDK3/cyclin E Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Cellular tumor antigen p53 Potency 5011.9 nM None
Homo sapiens Cellular tumor antigen p53 Potency 12589.3 nM None
Homo sapiens Cerebroside-sulfatase Potency 8492.1 nM None
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Chromobox protein homolog 1 Potency 50118.7 nM None
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 137.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Cytochrome P450 1A2 AC50 10000.0 nM None
Homo sapiens Cytochrome P450 2C19 AC50 10000.0 nM None
Homo sapiens Cytochrome P450 2C19 Potency 10000.0 nM None
Homo sapiens Cytochrome P450 2C9 AC50 39810.72 nM None
Homo sapiens Cytochrome P450 2C9 Potency 39810.7 nM None
Homo sapiens Cytochrome P450 2D6 AC50 25118.86 nM None
Homo sapiens Cytochrome P450 2D6 Potency 25118.9 nM None
Homo sapiens Cytochrome P450 3A4 AC50 31622.78 nM None
Homo sapiens Cytochrome P450 3A4 Potency 31622.8 nM None
Homo sapiens Death-associated protein kinase 1 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 1 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 10000.0 nM None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 25118.9 nM None
Homo sapiens DOPA decarboxylase IC50 1280000.0 nM 10.1016/j.bmcl.2014.04.047
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 125.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 130.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 19952.6 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 25118.9 nM None
Homo sapiens Ephrin type-A receptor 1 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 1 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Residual Activity 121.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 126.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 133.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 44.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Flap endonuclease 1 Potency 15003.0 nM None
Homo sapiens Flap endonuclease 1 Potency 29934.9 nM None
Homo sapiens Focal adhesion kinase 1 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Focal adhesion kinase 1 Residual Activity 140.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 126.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens HEK293 Potency 4107.8 nM None
Homo sapiens Hepatocyte growth factor receptor Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Hepatocyte growth factor receptor Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Histone acetyltransferase GCN5 Potency 31622.8 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 16833.6 nM None
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens HUVEC IC50 4930.0 nM 10.1016/j.bmc.2016.07.065
Homo sapiens Hypoxia-inducible factor 1 alpha Potency 31622.8 nM None
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 131.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 138.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 130.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 130.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens LIM domain kinase 1 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens LIM domain kinase 1 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 53.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK2 Potency 31622.8 nM None
Homo sapiens MAP kinase ERK2 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK2 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 alpha Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 alpha Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 delta Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 delta Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 31.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens MDA-MB-231 Inhibition 100.0 % 10.1016/j.bmc.2016.04.059
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 22387.2 nM None
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 25118.9 nM None
Homo sapiens Microtubule-associated protein tau Potency 501.2 nM None
Homo sapiens Microtubule-associated protein tau Potency 14125.4 nM None
Homo sapiens Microtubule-associated protein tau Potency 15848.9 nM None
Homo sapiens Microtubule-associated protein tau Potency 17782.8 nM None
Homo sapiens Misshapen-like kinase 1 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Misshapen-like kinase 1 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Monoamine oxidase A Activity 28.3 % 10.1016/j.bmcl.2018.06.023
Homo sapiens Monoamine oxidase A Activity 28.5 % 10.1016/j.bmcl.2018.06.023
Homo sapiens Monoamine oxidase A Activity 75.0 % 10.1016/j.bmcl.2018.06.023
Homo sapiens Monoamine oxidase A IC50 550.0 nM 10.1016/j.bmcl.2018.06.023
Homo sapiens Monoamine oxidase A Inhibition nan % 10.1016/j.bmcl.2018.06.023
Homo sapiens Monoamine oxidase A Ki 220.0 nM 10.1016/j.bmcl.2018.06.023
Homo sapiens Monoamine oxidase B Activity 94.3 % 10.1016/j.bmcl.2018.06.023
Homo sapiens Monoamine oxidase B IC50 20000.0 nM 10.1016/j.bmcl.2018.06.023
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 126.0 % 10.1042/bj20121418
Homo sapiens NCI-H1299 IC50 4280.0 nM 10.1016/j.bmc.2016.07.065
Homo sapiens NCI-H292 IC50 4960.0 nM 10.1016/j.bmc.2016.07.065
Homo sapiens NCI-H460 IC50 5140.0 nM 10.1016/j.bmc.2016.07.065
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Niemann-Pick C1 protein Potency 58047.9 nM None
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 16360.1 nM None
Homo sapiens Nuclear factor NF-kappa-B p105 subunit Potency 11220.2 nM None
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Peroxisome proliferator-activated receptor gamma IC50 566.0 nM 10.1016/j.bmcl.2016.07.067
Homo sapiens Peroxisome proliferator-activated receptor gamma IC50 566.0 nM 10.1016/j.ejmech.2021.113535
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C alpha Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C alpha Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C theta Residual Activity 66.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C theta Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 133.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens quadruplex DNA Activity nan None 10.1021/acs.jnatprod.7b00350
Homo sapiens quadruplex DNA EC50 2590.0 nM 10.1021/acs.jnatprod.7b00350
Homo sapiens quadruplex DNA EC50 3750.0 nM 10.1021/acs.jnatprod.7b00350
Homo sapiens Ras-related protein Rab-9A Potency 46109.1 nM None
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Regulator of G-protein signaling 4 Potency 6701.6 nM None
Homo sapiens Rho-associated protein kinase 1 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 1 Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 130.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 130.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 IC50 27000.0 nM 10.1021/acs.jmedchem.9b01509
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 53.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 130.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Potency 2930.9 nM None
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 137.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 130.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 66.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens SH-SY5Y Potency 5623.4 nM None
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition -0.7 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 24.9 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition 13.1 % 10.1021/jm300212s
Homo sapiens Stem cell growth factor receptor Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Stem cell growth factor receptor Residual Activity 123.0 % 10.1042/bj20121418
Homo sapiens Survival motor neuron protein Potency 7079.5 nM None
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Thrombopoietin Potency 1995.3 nM None
Homo sapiens Thyroid hormone receptor beta-1 Potency 70794.6 nM None
Homo sapiens Thyroid stimulating hormone receptor Potency 25118.9 nM None
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BRK Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BRK Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Residual Activity 121.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 121.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 67.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 44.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 132.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 66.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 12.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase YES Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase YES Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 1263.6 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 63095.7 nM None
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 2 Potency 25118.9 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 47.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Vitamin D receptor Potency 28183.8 nM None
Leishmania major 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Potency 15101.4 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 3981.1 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 7079.5 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 8912.5 nM None
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 3.1 ug.mL-1 10.1016/j.ejmech.2022.114173
Oryctolagus cuniculus Sarcoplasmic/endoplasmic reticulum calcium ATP-ase IC50 1200.0 nM 10.1021/acs.jmedchem.9b01509
Photinus pyralis Luciferin 4-monooxygenase Potency 31622.8 nM None
Rattus norvegicus Canalicular multispecific organic anion transporter 1 Activity nan None 10.1152/ajpgi.00271.2003
Rattus norvegicus Inositol monophosphatase 1 Potency 5011.9 nM None
Rattus norvegicus Muscarinic acetylcholine receptor M1 Potency 35481.3 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 39810.7 nM None
Saccharomyces cerevisiae Saccharomyces cerevisiae Potency 5804.8 nM None
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1016/j.ejmech.2012.12.027
Staphylococcus aureus Staphylococcus aureus MIC=>90 4.0 ug ml-1 10.1016/j.bmcl.2013.02.016
Staphylococcus aureus Staphylococcus aureus MIC90 4.0 ug.mL-1 10.1016/j.bmc.2012.10.009
Trypanosoma brucei 6-phospho-1-fructokinase Potency 19011.5 nM None
None NON-PROTEIN TARGET GI 88.4 % 10.1016/j.bmcl.2016.11.031
None NON-PROTEIN TARGET GI 92.7 % 10.1016/j.bmcl.2016.11.031
None NON-PROTEIN TARGET IC50 1490.0 nM 10.1016/j.bmcl.2016.11.031
None NON-PROTEIN TARGET IC50 12700.0 nM 10.1016/j.bmcl.2016.11.031
None NON-PROTEIN TARGET Inhibition 100.0 % 10.1016/j.bmc.2016.04.059
None NON-PROTEIN TARGET Potency 74.9 nM None
None NON-PROTEIN TARGET Potency 10583.9 nM None
None NON-PROTEIN TARGET Potency 16774.4 nM None
None NON-PROTEIN TARGET Potency 18821.2 nM None
None NON-PROTEIN TARGET Potency 23485.0 nM None
None Unchecked Activity nan None 10.1016/j.bmc.2016.04.059
None Unchecked Activity nan None 10.1016/j.bmc.2020.115732
None Unchecked Delta Tm 0.1 degrees C 10.1016/j.bmc.2016.04.059
None Unchecked Delta Tm 19.6 degrees C 10.1016/j.bmc.2016.04.059
None Unchecked Delta Tm 24.3 degrees C 10.1016/j.bmc.2016.04.059
None Unchecked IC50 1500.0 nM 10.1021/acs.jmedchem.9b01509
None Unchecked IC50 3730.0 nM 10.1016/j.bmc.2016.07.065
None Unchecked IC50 6600.0 nM 10.1016/j.bmc.2016.04.059
None Unchecked K 7.35 10'5/M 10.1016/j.bmc.2016.04.059
None Unchecked Potency 833.3 nM None
None Unchecked Potency 1000.0 nM None
None Unchecked Potency 1320.7 nM None
None Unchecked Potency 1662.6 nM None
None Unchecked Potency 2956.6 nM None
None Unchecked Potency 4466.8 nM None
None Unchecked Potency 6619.0 nM None
None Unchecked Potency 7304.8 nM None
None Unchecked Potency 8332.8 nM None
None Unchecked Potency 8912.5 nM None
None Unchecked Potency 9200.0 nM None
None Unchecked Potency 10000.0 nM None
None Unchecked Potency 12589.3 nM None
None Unchecked Potency 12995.3 nM None
None Unchecked Potency 17782.8 nM None
None Unchecked Potency 18654.8 nM None
None Unchecked Potency 28183.8 nM None
None Unchecked Potency 29824.5 nM None
None Unchecked Potency 31622.8 nM None
None Unchecked Potency 33173.4 nM None
None Unchecked Potency 35481.3 nM None
None Unchecked Potency 39810.7 nM None
None Unchecked Ratio EC50 0.7 None 10.1021/acs.jnatprod.7b00350
None Unchecked Ratio IC50 0.48 None 10.1016/j.bmc.2016.07.065
None Unchecked Ratio IC50 0.64 None 10.1016/j.bmc.2016.07.065
None Unchecked Ratio IC50 0.73 None 10.1016/j.bmc.2016.07.065
None Unchecked Ratio IC50 0.75 None 10.1016/j.bmc.2016.07.065
None Unchecked Ratio IC50 0.87 None 10.1016/j.bmc.2016.07.065
None Unchecked Ratio IC50 0.96 None 10.1016/j.bmc.2016.07.065
None Unchecked Ratio IC50 0.99 None 10.1016/j.bmc.2016.07.065
None Unchecked Ratio IC50 1.15 None 10.1016/j.bmc.2016.07.065
None Unchecked Ratio IC50 36.4 None 10.1016/j.bmcl.2018.06.023
None Unchecked Selectivity Index 5.92 None 10.1016/j.ejmech.2020.112415

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT011891 COc1ccc2c(c1OC)CN(C)c1c-2ccc2cc3c(cc12)OCO3>>COc1ccc2c(c[n+](C)c3c4cc5c(cc4ccc23)OCO5)c1OC RXN-15542
AKRT011899 COc1ccc2c(c[n+](C)c3c4cc5c(cc4ccc23)OCO5)c1OC>>COc1ccc2c(c1OC)CN(C)c1c-2ccc2cc3c(cc12)OCO3 RXN-15543