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name Structure Reference Source Properties Activities Metabolism

1,6-dihydroxyphenazine-5,10-diium-5,10-bis(olate)

AlkaPlorer ID: AK463716

Synonym: None

IUPAC Name: 5,10-dioxidophenazine-5,10-diium-1,6-diol

Structure

SMILES: [O-][N+]1=C2C=CC=C(O)C2=[N+]([O-])C2=C1C(O)=CC=C2

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InChI: InChI=1S/C12H8N2O4/c15-9-5-1-3-7-11(9)14(18)8-4-2-6-10(16)12(8)13(7)17/h1-6,15-16H

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InChIKey: NBMOVCYIGUDQJE-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Brevibacterium iodinum Brevibacterium Brevibacteriaceae Micrococcales Actinomycetes Actinomycetota None Bacteria

Properties Information

Molecule Weight: 244.206

TPSA？: 94.34

MolLogP？: 0.6709999999999998

Number of H-Donors: 2

Number of H-Acceptors: 4

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Enterococcus faecium Enterococcus faecium MIC 0.35 ug.mL-1 10.1021/acs.jnatprod.6b00235
Enterococcus faecium Enterococcus faecium MIC 0.7 ug.mL-1 10.1021/acs.jnatprod.6b00235
Homo sapiens 786-0 GI50 30199.52 nM None
Homo sapiens A498 GI50 100000.0 nM None
Homo sapiens A549 GI50 84722.74 nM None
Homo sapiens ACHN GI50 14223.29 nM None
Homo sapiens BT-549 GI50 46025.66 nM None
Homo sapiens CAKI-1 GI50 25061.09 nM None
Homo sapiens CCRF-CEM GI50 5559.04 nM None
Homo sapiens COLO 205 GI50 52844.53 nM None
Homo sapiens DU-145 GI50 100000.0 nM None
Homo sapiens EKVX GI50 23768.4 nM None
Homo sapiens HCT-116 GI50 21379.62 nM None
Homo sapiens HCT-15 GI50 46558.61 nM None
Homo sapiens HL-60 GI50 47863.01 nM None
Homo sapiens HOP-62 GI50 27925.44 nM None
Homo sapiens HOP-92 GI50 22698.65 nM None
Homo sapiens Hs-578T GI50 100000.0 nM None
Homo sapiens HT-29 GI50 100000.0 nM None
Homo sapiens IGROV-1 GI50 6531.31 nM None
Homo sapiens K562 GI50 39174.19 nM None
Homo sapiens KM12 GI50 37497.3 nM None
Homo sapiens LOX IMVI GI50 56754.46 nM None
Homo sapiens M14 GI50 100000.0 nM None
Homo sapiens MCF7 GI50 20653.8 nM None
Homo sapiens MDA-MB-435 GI50 100000.0 nM None
Homo sapiens MDA-N GI50 100000.0 nM None
Homo sapiens MOLM-13 Activity nan None 10.1016/j.bmc.2017.02.058
Homo sapiens MOLM-13 EC50 790.0 nM 10.1016/j.bmc.2017.02.058
Homo sapiens MOLM-13 EC50 2000.0 nM 10.1016/j.bmc.2017.02.058
Homo sapiens MOLT-4 GI50 3990.25 nM None
Homo sapiens NCI/ADR-RES GI50 70794.58 nM None
Homo sapiens NCI-H23 GI50 94623.72 nM None
Homo sapiens NCI-H322M GI50 100000.0 nM None
Homo sapiens NCI-H460 GI50 30130.06 nM None
Homo sapiens NCI-H522 GI50 20370.42 nM None
Homo sapiens OVCAR-3 GI50 29174.27 nM None
Homo sapiens OVCAR-4 GI50 42657.95 nM None
Homo sapiens OVCAR-5 GI50 100000.0 nM None
Homo sapiens OVCAR-8 GI50 25941.79 nM None
Homo sapiens PC-3 GI50 53088.44 nM None
Homo sapiens RPMI-8226 GI50 18578.04 nM None
Homo sapiens RXF 393 GI50 60394.86 nM None
Homo sapiens SF-268 GI50 31768.74 nM None
Homo sapiens SF-295 GI50 57942.87 nM None
Homo sapiens SF-539 GI50 32658.78 nM None
Homo sapiens SK-MEL-5 GI50 53456.44 nM None
Homo sapiens SK-OV-3 GI50 45708.82 nM None
Homo sapiens SNB-19 GI50 92044.96 nM None
Homo sapiens SNB-75 GI50 100000.0 nM None
Homo sapiens SW-620 GI50 47863.01 nM None
Homo sapiens T47D GI50 40179.08 nM None
Homo sapiens TK-10 GI50 23442.29 nM None
Homo sapiens U-251 GI50 43251.38 nM None
Homo sapiens UACC-257 GI50 37931.5 nM None
Homo sapiens UO-31 GI50 100000.0 nM None
Rattus norvegicus H9c2 EC50 50000.0 nM 10.1039/d1md00020a
Rattus norvegicus NRK EC50 50000.0 nM 10.1039/d1md00020a
None ADMET permeability -5.64 None 10.1039/d1md00020a

Metabolism Information