Thiamethoxam
AlkaPlorer ID: AK472975
Synonym: None
IUPAC Name: (NE)-N-[3-[(2-chloro-1,3-thiazol-5-yl)methyl]-5-methyl-1,3,5-oxadiazinan-4-ylidene]nitramide
Structure
SMILES: CN1COCN(CC2=CN=C(Cl)S2)/C1=N\[N+](=O)[O-]
InChI: InChI=1S/C8H10ClN5O3S/c1-12-4-17-5-13(8(12)11-14(15)16)3-6-2-10-7(9)18-6/h2H,3-5H2,1H3/b11-8-
InChIKey: NWWZPOKUUAIXIW-FLIBITNWSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces canus | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 291.72
TPSA？: 84.1
MolLogP？: 1.0231999999999997
Number of H-Donors: 0
Number of H-Acceptors: 5
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Agaricus bisporus | Tyrosinase | IC50 | 1000000.0 | nM | 10.1021/jf200485k |
| Agaricus bisporus | Tyrosinase | Inhibition | 13.0 | % | 10.1021/jf200485k |
| Amphimallon majale | Amphimallon majale | Activity | 13.1 | % | 10.1002/ps.1835 |
| Amphimallon majale | Amphimallon majale | Activity | 16.4 | % | 10.1002/ps.1835 |
| Amphimallon majale | Amphimallon majale | Activity | 35.1 | % | 10.1002/ps.1835 |
| Anomala orientalis | Anomala orientalis | Activity | 27.0 | % | 10.1002/ps.1835 |
| Anomala orientalis | Anomala orientalis | Activity | 57.5 | % | 10.1002/ps.1835 |
| Anomala orientalis | Anomala orientalis | Activity | 78.7 | % | 10.1002/ps.1835 |
| Aphis gossypii | Aphis gossypii | Activity | 0.12 | mg | 10.1002/ps.2207 |
| Aphis gossypii | Aphis gossypii | Activity | 0.14 | mg | 10.1002/ps.2207 |
| Aphis gossypii | Aphis gossypii | Activity | 0.16 | mg | 10.1002/ps.2207 |
| Aphis gossypii | Aphis gossypii | Activity | nan | None | 10.1002/ps.2207 |
| Aphis gossypii | Aphis gossypii | Inhibition | 73.7 | % | 10.1002/ps.2207 |
| Aphis gossypii | Aphis gossypii | LC20 | 0.96 | ug ml-1 | 10.1002/ps.2207 |
| Aphis gossypii | Aphis gossypii | LC50 | 1.6 | microg/mL2 | 10.1002/ps.2207 |
| Aphis gossypii | Aphis gossypii | LC50 | 1.69 | microg/mL2 | 10.1002/ps.2207 |
| Aphis gossypii | Aphis gossypii | RatioLC50 | 1.06 | None | 10.1002/ps.2207 |
| Aphis gossypii | Aphis gossypii | Survival | 6.78 | day | 10.1002/ps.2207 |
| Aphis medicaginis | Aphis medicaginis | mortality | 100.0 | % | 10.1016/j.ejmech.2010.09.047 |
| Bemisia tabaci | Bemisia tabaci | Activity | nan | None | 10.1002/ps.2056 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 1.19 | ug.mL-1 | 10.1002/ps.1808 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 1.7 | ppm | 10.1021/jf201927t |
| Bemisia tabaci | Bemisia tabaci | LC50 | 4.1 | ug.mL-1 | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 4.5 | ug.mL-1 | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 8.6 | ug.mL-1 | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 12.0 | ug.mL-1 | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 15.0 | ug.mL-1 | 10.1002/ps.1877 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 15.0 | ug.mL-1 | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 17.6 | ug.mL-1 | 10.1002/ps.1877 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 18.5 | ug.mL-1 | 10.1002/ps.1877 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 64.0 | ug.mL-1 | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 100.0 | ug.mL-1 | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 110.0 | ug.mL-1 | 10.1002/ps.1808 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 143.0 | ug.mL-1 | 10.1002/ps.1877 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 169.0 | ug.mL-1 | 10.1002/ps.1877 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 189.0 | ug.mL-1 | 10.1002/ps.1877 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 289.0 | ug.mL-1 | 10.1002/ps.1808 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 290.0 | ug.mL-1 | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 300.0 | ug.mL-1 | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 334.0 | ug.mL-1 | 10.1002/ps.1877 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 450.0 | ug.mL-1 | 10.1002/ps.1877 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 450.0 | ug.mL-1 | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 451.0 | ug.mL-1 | 10.1002/ps.1877 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 452.0 | ug.mL-1 | 10.1002/ps.1877 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 980.0 | ug.mL-1 | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 1165.0 | ug.mL-1 | 10.1002/ps.1877 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 2000.0 | ug.mL-1 | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | LC50 | 3000.0 | ppm | 10.1021/jf201927t |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 0.29 | None | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 0.95 | None | 10.1002/ps.1877 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 0.99 | None | 10.1002/ps.1877 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 1.0 | None | 10.1002/ps.1877 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 1.17 | None | 10.1002/ps.1877 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 2.37 | None | 10.1002/ps.1877 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 2.9 | None | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 3.14 | None | 10.1002/ps.1877 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 3.7 | None | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 4.5 | None | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 6.3 | None | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 7.0 | None | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 9.62 | None | 10.1002/ps.1877 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 19.0 | None | 10.1002/ps.1877 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 25.6 | None | 10.1002/ps.1877 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 66.3 | None | 10.1002/ps.1877 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 73.0 | None | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 92.0 | None | 10.1002/ps.1808 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 150.0 | None | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 240.0 | None | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 243.0 | None | 10.1002/ps.1808 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 490.0 | None | 10.1002/ps.1989 |
| Bemisia tabaci | Bemisia tabaci | RatioLC50 | 1764.7 | None | 10.1021/jf201927t |
| Clonostachys rosea | Clonostachys rosea | GI | 0.1 | % | 10.1584/jpestics.D11-055 |
| Clonostachys rosea | Clonostachys rosea | GI | 0.36 | % | 10.1584/jpestics.D11-055 |
| Clonostachys rosea | Clonostachys rosea | GI | 0.51 | % | 10.1584/jpestics.D11-055 |
| Clonostachys rosea | Clonostachys rosea | GI | 1.82 | % | 10.1584/jpestics.D11-055 |
| Clonostachys rosea | Clonostachys rosea | GI | 2.65 | % | 10.1584/jpestics.D11-055 |
| Clonostachys rosea | Clonostachys rosea | Inhibition | 1.0 | % | 10.1584/jpestics.D11-055 |
| Drosophila suzukii | Drosophila suzukii | Activity | nan | None | 10.1002/ps.2242 |
| Frankliniella occidentalis | Frankliniella occidentalis | LC50 | 157.8 | ug.mL-1 | 10.1002/ps.3372 |
| Frankliniella occidentalis | Frankliniella occidentalis | LC50 | 209.2 | ug.mL-1 | 10.1002/ps.3372 |
| Frankliniella occidentalis | Frankliniella occidentalis | LC50 | 298.0 | ug.mL-1 | 10.1002/ps.3372 |
| Frankliniella occidentalis | Frankliniella occidentalis | LC50 | 352.0 | ug.mL-1 | 10.1002/ps.3372 |
| Frankliniella occidentalis | Frankliniella occidentalis | LC50 | 1674.0 | ug.mL-1 | 10.1002/ps.3372 |
| Frankliniella occidentalis | Frankliniella occidentalis | mortality | 0.0 | % | 10.1002/ps.3372 |
| Frankliniella occidentalis | Frankliniella occidentalis | mortality | 10.0 | % | 10.1002/ps.3372 |
| Frankliniella occidentalis | Frankliniella occidentalis | mortality | 13.3 | % | 10.1002/ps.3372 |
| Frankliniella occidentalis | Frankliniella occidentalis | mortality | 16.7 | % | 10.1002/ps.3372 |
| Frankliniella occidentalis | Frankliniella occidentalis | mortality | 20.0 | % | 10.1002/ps.3372 |
| Frankliniella occidentalis | Frankliniella occidentalis | RatioLC50 | 0.8 | None | 10.1002/ps.3372 |
| Frankliniella occidentalis | Frankliniella occidentalis | RatioLC50 | 1.0 | None | 10.1002/ps.3372 |
| Frankliniella occidentalis | Frankliniella occidentalis | RatioLC50 | 3.0 | None | 10.1002/ps.3372 |
| Frankliniella occidentalis | Frankliniella occidentalis | RatioLC50 | 4.8 | None | 10.1002/ps.3372 |
| Galendromus occidentalis | Galendromus occidentalis | Activity | 0.33 | /day | 10.1002/ps.1721 |
| Galendromus occidentalis | Galendromus occidentalis | Activity | 0.58 | /day | 10.1002/ps.1721 |
| Galendromus occidentalis | Galendromus occidentalis | Activity | 1.44 | /day | 10.1002/ps.1721 |
| Galendromus occidentalis | Galendromus occidentalis | mortality | 4.3 | % | 10.1002/ps.1721 |
| Galendromus occidentalis | Galendromus occidentalis | mortality | 6.2 | % | 10.1002/ps.1721 |
| Galendromus occidentalis | Galendromus occidentalis | mortality | 8.0 | % | 10.1002/ps.1721 |
| Galendromus occidentalis | Galendromus occidentalis | mortality | 8.5 | % | 10.1002/ps.1721 |
| Galendromus occidentalis | Galendromus occidentalis | Repellency | 5.1 | % | 10.1002/ps.1721 |
| Galendromus occidentalis | Galendromus occidentalis | Repellency | 34.0 | % | 10.1002/ps.1721 |
| Galendromus occidentalis | Galendromus occidentalis | Repellency | 41.0 | % | 10.1002/ps.1721 |
| Glycine max | Glycine max | Activity | nan | None | 10.1021/jf200485k |
| Gossypium hirsutum | Cotyledon | Drug uptake | nan | None | 10.1002/ps.2056 |
| Gossypium hirsutum | Gossypium hirsutum | Activity | nan | None | 10.1021/jf200485k |
| Gossypium hirsutum | Leaf | Drug uptake | nan | None | 10.1002/ps.2056 |
| Homo sapiens | Bile acid receptor FXR | Potency | 3.2 | nM | None |
| Homo sapiens | Nuclear factor erythroid 2-related factor 2 | Potency | 54482.7 | nM | None |
| Homo sapiens | Thyroid hormone receptor beta-1 | Potency | 70.8 | nM | None |
| Lissorhoptrus oryzophilus | Lissorhoptrus oryzophilus | Activity | 5.2 | mm2 | 10.1002/ps.3382 |
| Lissorhoptrus oryzophilus | Lissorhoptrus oryzophilus | Activity | 5.5 | mm2 | 10.1002/ps.3382 |
| Lissorhoptrus oryzophilus | Lissorhoptrus oryzophilus | Activity | 6.4 | mm2 | 10.1002/ps.3382 |
| Lissorhoptrus oryzophilus | Lissorhoptrus oryzophilus | Activity | 6.6 | mm2 | 10.1002/ps.3382 |
| Lissorhoptrus oryzophilus | Lissorhoptrus oryzophilus | Activity | 6.9 | mm2 | 10.1002/ps.3382 |
| Lissorhoptrus oryzophilus | Lissorhoptrus oryzophilus | Activity | nan | None | 10.1002/ps.3382 |
| Lissorhoptrus oryzophilus | Lissorhoptrus oryzophilus | LC50 | 142.0 | pg | 10.1002/ps.3382 |
| Lissorhoptrus oryzophilus | Lissorhoptrus oryzophilus | LC50 | 447.0 | pg | 10.1002/ps.3382 |
| Lissorhoptrus oryzophilus | Lissorhoptrus oryzophilus | mortality | 21.3 | % | 10.1002/ps.3382 |
| Lissorhoptrus oryzophilus | Lissorhoptrus oryzophilus | mortality | 22.5 | % | 10.1002/ps.3382 |
| Lissorhoptrus oryzophilus | Lissorhoptrus oryzophilus | mortality | 28.8 | % | 10.1002/ps.3382 |
| Lissorhoptrus oryzophilus | Lissorhoptrus oryzophilus | mortality | 42.5 | % | 10.1002/ps.3382 |
| Lissorhoptrus oryzophilus | Lissorhoptrus oryzophilus | mortality | 45.0 | % | 10.1002/ps.3382 |
| Lygaeidae | Lygaeidae | Activity | nan | None | 10.1002/ps.3387 |
| Maladera castanea | Maladera castanea | Activity | 28.2 | % | 10.1002/ps.1835 |
| Maladera castanea | Maladera castanea | Activity | 39.1 | % | 10.1002/ps.1835 |
| Maladera castanea | Maladera castanea | Activity | 72.8 | % | 10.1002/ps.1835 |
| Myzus persicae | Myzus persicae | LC50 | 0.5 | ppm | 10.1002/ps.3413 |
| Myzus persicae | Myzus persicae | LC50 | 108.0 | ppm | 10.1002/ps.3413 |
| Oryctolagus cuniculus | Aldehyde oxidase | IC50 | 1000000.0 | nM | 10.1021/jf200485k |
| Oryctolagus cuniculus | Aldehyde oxidase | Inhibition | 4.0 | % | 10.1021/jf200485k |
| Paralobesia | Paralobesia | Activity | 7.0 | % | 10.1002/ps.2285 |
| Paralobesia | Paralobesia | Activity | 25.3 | % | 10.1002/ps.2285 |
| Popillia japonica | Popillia japonica | Activity | 27.67 | % | 10.1002/ps.2285 |
| Popillia japonica | Popillia japonica | Activity | 48.1 | % | 10.1002/ps.1835 |
| Popillia japonica | Popillia japonica | Activity | 74.9 | % | 10.1002/ps.1835 |
| Popillia japonica | Popillia japonica | Activity | 91.0 | % | 10.1002/ps.1835 |
| Popillia japonica | Popillia japonica | Activity | nan | None | 10.1002/ps.2285 |
| Sitobion avenae | Sitobion avenae | Activity | nan | None | 10.1021/np400126q |
| Trichogramma nubilale | Trichogramma nubilale | LC50 | 1.86 | mgAi/L | 10.1016/j.cropro.2011.12.007 |
| Trichogramma nubilale | Trichogramma nubilale | LC95 | 13.35 | mgAi/L | 10.1016/j.cropro.2011.12.007 |
| Trichogramma nubilale | Trichogramma nubilale | Ratio | 12.1 | None | 10.1016/j.cropro.2011.12.007 |
| Urochloa mutica | Urochloa mutica | Drug uptake | 0.16 | ug | 10.1002/ps.3387 |
| Urochloa mutica | Urochloa mutica | Drug uptake | 0.6 | ug | 10.1002/ps.3387 |
| Urochloa mutica | Urochloa mutica | Drug uptake | 6.2 | ug | 10.1002/ps.3387 |
| Urochloa mutica | Urochloa mutica | Drug uptake | nan | None | 10.1002/ps.3387 |
| Vitis vinifera | Vitis vinifera | Activity | nan | None | 10.1021/jf200485k |
| Zea mays | Zea mays | Activity | nan | None | 10.1021/jf200485k |
| None | ADMET | Activity | nan | None | 10.1016/j.cropro.2007.08.004 |
| None | ADMET | LC50 | 0.52 | mgAi/L | 10.1016/j.cropro.2007.08.004 |
| None | ADMET | mortality | 66.8 | % | 10.1016/j.cropro.2007.08.004 |
| None | Unchecked | IC50 | 1000000.0 | nM | 10.1021/jf200485k |
| None | Unchecked | Inhibition | 12.0 | % | 10.1021/jf200485k |
| None | Unchecked | Ki | 481.0 | nM | 10.1002/ps.3413 |
| None | Unchecked | Ki | 2900.0 | nM | 10.1002/ps.3413 |
| None | Unchecked | Ratio | 270.0 | None | 10.1002/ps.3413 |