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name Structure Reference Source Properties Activities Metabolism

Clothianidin

AlkaPlorer ID: AK488184

Synonym: None

IUPAC Name: 1-[(2-chloro-1,3-thiazol-5-yl)methyl]-2-methyl-3-nitroguanidine

Structure

SMILES: CN=C(NCC1=CN=C(Cl)S1)N[N+](=O)[O-]

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InChI: InChI=1S/C6H8ClN5O2S/c1-8-6(11-12(13)14)10-3-4-2-9-5(7)15-4/h2H,3H2,1H3,(H2,8,10,11)

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InChIKey: PGOOBECODWQEAB-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Apis cerana Apis Apidae Hymenoptera Insecta Arthropoda Metazoa Eukaryota

Properties Information

Molecule Weight: 249.683

TPSA？: 92.45

MolLogP？: 0.6531999999999998

Number of H-Donors: 2

Number of H-Acceptors: 5

RingCount: 1

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Agaricus bisporus Tyrosinase IC50 1000000.0 nM 10.1021/jf200485k
Agaricus bisporus Tyrosinase Inhibition 15.0 % 10.1021/jf200485k
Amphimallon majale Amphimallon majale Activity 19.8 % 10.1002/ps.1835
Amphimallon majale Amphimallon majale Activity 22.6 % 10.1002/ps.1835
Amphimallon majale Amphimallon majale Activity 44.3 % 10.1002/ps.1835
Anomala orientalis Anomala orientalis Activity 56.0 % 10.1002/ps.1835
Anomala orientalis Anomala orientalis Activity 89.3 % 10.1002/ps.1835
Anomala orientalis Anomala orientalis Activity 98.6 % 10.1002/ps.1835
Aphis gossypii Aphis gossypii Activity 0.12 mg 10.1002/ps.2207
Aphis gossypii Aphis gossypii Activity 0.14 mg 10.1002/ps.2207
Aphis gossypii Aphis gossypii Activity 0.16 mg 10.1002/ps.2207
Aphis gossypii Aphis gossypii Activity nan None 10.1002/ps.2207
Aphis gossypii Aphis gossypii Inhibition 72.7 % 10.1002/ps.2207
Aphis gossypii Aphis gossypii LC20 1.23 ug ml-1 10.1002/ps.2207
Aphis gossypii Aphis gossypii LC50 1.82 microg/mL2 10.1002/ps.2207
Aphis gossypii Aphis gossypii LC50 2.18 microg/mL2 10.1002/ps.2207
Aphis gossypii Aphis gossypii mortality 100.0 % 10.1021/jf803985r
Aphis gossypii Aphis gossypii RatioLC50 1.2 None 10.1002/ps.2207
Aphis gossypii Aphis gossypii Survival 6.61 day 10.1002/ps.2207
Ceutorhynchus obstrictus Ceutorhynchus obstrictus Activity nan None 10.1002/ps.1818
Ceutorhynchus obstrictus Ceutorhynchus obstrictus Inhibition 52.2 % 10.1002/ps.1818
Ceutorhynchus obstrictus Ceutorhynchus obstrictus Inhibition nan % 10.1002/ps.1818
Cheumatopsyche Cheumatopsyche EC50 0.00444 ug.mL-1 10.1584/jpestics.G08-26
Contarinia nasturtii Contarinia nasturtii Activity 100.0 % 10.1002/ps.1818
Daphnia magna Daphnia magna EC50 119.0 ug.mL-1 10.1584/jpestics.G08-26
Drosophila melanogaster Acetylcholine receptor subunit beta-like 2 IC50 2.2 nM 10.1046/j.1471-4159.2000.751294.x
Drosophila melanogaster Acetylcholine receptor subunit beta-like 2 IC50 2.3 nM 10.1046/j.1471-4159.2000.751294.x
Drosophila melanogaster Acetylcholine receptor subunit beta-like 2 Inhibition nan % 10.1046/j.1471-4159.2000.751294.x
Glycine max Glycine max Activity nan None 10.1021/jf200485k
Gossypium hirsutum Gossypium hirsutum Activity nan None 10.1021/jf200485k
Homo sapiens Cellular tumor antigen p53 Potency 28183.8 nM None
Homo sapiens Glucocorticoid receptor Potency 89.1 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 61130.6 nM None
Lygaeidae Lygaeidae Activity nan None 10.1002/ps.3387
Maladera castanea Maladera castanea Activity 39.8 % 10.1002/ps.1835
Maladera castanea Maladera castanea Activity 75.7 % 10.1002/ps.1835
Maladera castanea Maladera castanea Activity 100.0 % 10.1002/ps.1835
Musca domestica Nicotinic acetylcholine receptor alpha 5 subunit IC50 1.8 nM 10.1046/j.1471-4159.2000.751294.x
Myzus persicae Myzus persicae LC50 0.3 ppm 10.1002/ps.3413
Myzus persicae Myzus persicae LC50 904.0 ppm 10.1002/ps.3413
Oryctolagus cuniculus Aldehyde oxidase IC50 1000000.0 nM 10.1021/jf200485k
Oryctolagus cuniculus Aldehyde oxidase Inhibition 4.0 % 10.1021/jf200485k
Paralobesia Paralobesia Activity 6.0 % 10.1002/ps.2285
Paralobesia Paralobesia Activity 31.7 % 10.1002/ps.2285
Periplaneta americana Nicotinic acetylcholine receptor alpha8 subunit EC50 1584.89 nM 10.1584/jpestics.31.35
Periplaneta americana Nicotinic acetylcholine receptor alpha8 subunit Imax 0.68 None 10.1584/jpestics.31.35
Periplaneta americana Periplaneta americana pMLD 10.2 None 10.1584/jpestics.31.35
Popillia japonica Popillia japonica Activity 4.0 % 10.1002/ps.1835
Popillia japonica Popillia japonica Activity 22.9 % 10.1002/ps.1835
Popillia japonica Popillia japonica Activity 32.8 % 10.1002/ps.1835
Popillia japonica Popillia japonica Activity 48.3 % 10.1002/ps.2285
Popillia japonica Popillia japonica Activity nan None 10.1002/ps.2285
Spinacia oleracea Spinacia oleracea Activity nan None 10.1021/jf200485k
Urochloa mutica Urochloa mutica Drug uptake 0.19 ug 10.1002/ps.3387
Urochloa mutica Urochloa mutica Drug uptake 0.66 ug 10.1002/ps.3387
Urochloa mutica Urochloa mutica Drug uptake 1.56 ug 10.1002/ps.3387
Urochloa mutica Urochloa mutica Drug uptake 6.48 ug 10.1002/ps.3387
Vitis vinifera Vitis vinifera Activity nan None 10.1021/jf200485k
Zea mays Zea mays Activity nan None 10.1021/jf200485k
None No relevant target log K 0.17 None 10.1584/jpestics.31.35
None No relevant target log KOW 0.7 None 10.1584/jpestics.G08-26
None Unchecked IC50 9.2 nM 10.1046/j.1471-4159.2000.751294.x
None Unchecked IC50 1860000.0 nM 10.1021/jf200485k
None Unchecked Inhibition nan % 10.1046/j.1471-4159.2000.751294.x
None Unchecked Ki 0.058 nM 10.1002/ps.3413
None Unchecked Ki 2.7 nM 10.1002/ps.3413
None Unchecked Ki 4.0 nM 10.1021/jf803985r
None Unchecked Ki 574.0 nM 10.1073/pnas.0703309104
None Unchecked Ki 808.0 nM 10.1073/pnas.0703309104
None Unchecked Ratio 3013.0 None 10.1002/ps.3413
None Unchecked Ratio EC50 4.43 None 10.1584/jpestics.G08-26

Metabolism Information