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name Structure Reference Source Properties Activities Metabolism

Desglymidodrine

AlkaPlorer ID: AK546322

Synonym: None

IUPAC Name: 2-amino-1-(2,5-dimethoxyphenyl)ethanol

Structure

SMILES: COC1=CC=C(OC)C(C(O)CN)=C1

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InChI: InChI=1S/C10H15NO3/c1-13-7-3-4-10(14-2)8(5-7)9(12)6-11/h3-5,9,12H,6,11H2,1-2H3

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InChIKey: VFRCNXKYZVQYLX-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 197.234

TPSA？: 64.71

MolLogP？: 0.6959

Number of H-Donors: 2

Number of H-Acceptors: 4

RingCount: 1

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Canis lupus familiaris Canis familiaris ED20 250.0 nM kg-1 10.1021/jm025550h
Canis lupus familiaris Canis familiaris ED5 205.0 nM kg-1 10.1021/jm025550h
Canis lupus familiaris Canis familiaris ED delta20 250.0 nM kg-1 10.1021/jm030551a
Canis lupus familiaris Canis familiaris ED delta5 205.0 nM kg-1 10.1021/jm030551a
Canis lupus familiaris Canis familiaris Ratio 1.3 None 10.1021/jm030551a
Canis lupus familiaris Canis familiaris Selectivity Index 1.3 None 10.1007/s00044-004-0020-z
Homo sapiens Adrenergic receptors; alpha-1 A & B Selectivity 3.5 None 10.1021/jm025550h
Homo sapiens Adrenergic receptors; alpha-1 A & B Selectivity 12.0 uM 10.1021/jm025550h
Homo sapiens Alpha-1a adrenergic receptor EC50 7100.0 nM 10.1021/jm025550h
Homo sapiens Alpha-2a adrenergic receptor Ki 1445.44 nM 10.1021/jm030551a
Homo sapiens Alpha adrenergic receptor (1a and 1d) Selectivity 0.3 uM 10.1021/jm025550h
Homo sapiens Alpha adrenergic receptor (1a and 1d) Selectivity 1.0 None 10.1021/jm025550h
Mesocricetus auratus Alpha-1b adrenergic receptor Ki 6900.0 nM 10.1021/jm025550h
Mesocricetus auratus Alpha-1b adrenergic receptor Ki 6918.31 nM 10.1007/s00044-004-0020-z
Mesocricetus auratus Alpha-1b adrenergic receptor Ki 6918.31 nM 10.1021/jm030551a
Oryctolagus cuniculus Alpha-1a adrenergic receptor EC50 7079.46 nM 10.1007/s00044-004-0020-z
Oryctolagus cuniculus Alpha-1a adrenergic receptor Efficacy 133.0 % 10.1007/s00044-004-0020-z
Oryctolagus cuniculus Alpha-1a adrenergic receptor Efficacy 133.0 % 10.1021/jm030551a
Oryctolagus cuniculus Alpha-1a adrenergic receptor pD2 5.15 None 10.1021/jm030551a
Oryctolagus cuniculus Oryctolagus cuniculus Efficacy 133.0 % 10.1021/jm025550h
Rattus norvegicus Adrenergic receptor alpha-1 Kd 91201.08 nM 10.1021/jm00356a026
Rattus norvegicus Adrenergic receptor alpha-1 pA10 3.3 None 10.1021/jm00356a026
Rattus norvegicus Adrenergic receptor alpha-1 pA2-pA10 0.74 None 10.1021/jm00356a026
Rattus norvegicus Adrenergic receptor alpha-1 pD10 6.0 None 10.1021/jm00356a026
Rattus norvegicus Adrenergic receptor alpha-1 pD2 5.15 None 10.1021/jm00356a026
Rattus norvegicus Alpha-1a adrenergic receptor Ki 1995.26 nM 10.1007/s00044-004-0020-z
Rattus norvegicus Alpha-1a adrenergic receptor Ki 1995.26 nM 10.1021/jm030551a
Rattus norvegicus Alpha-1a adrenergic receptor Ki 2000.0 nM 10.1021/jm025550h
Rattus norvegicus Alpha-1b adrenergic receptor EC50 85000.0 nM 10.1021/jm025550h
Rattus norvegicus Alpha-1b adrenergic receptor EC50 85113.8 nM 10.1007/s00044-004-0020-z
Rattus norvegicus Alpha-1b adrenergic receptor Efficacy 68.0 % 10.1007/s00044-004-0020-z
Rattus norvegicus Alpha-1b adrenergic receptor Efficacy 68.0 % 10.1021/jm030551a
Rattus norvegicus Alpha-1b adrenergic receptor pD2 4.07 None 10.1021/jm030551a
Rattus norvegicus Alpha-1d adrenergic receptor EC50 1862.09 nM 10.1007/s00044-004-0020-z
Rattus norvegicus Alpha-1d adrenergic receptor EC50 1900.0 nM 10.1021/jm025550h
Rattus norvegicus Alpha-1d adrenergic receptor Efficacy 68.0 % 10.1007/s00044-004-0020-z
Rattus norvegicus Alpha-1d adrenergic receptor Efficacy 68.0 % 10.1021/jm030551a
Rattus norvegicus Alpha-1d adrenergic receptor Ki 1659.59 nM 10.1007/s00044-004-0020-z
Rattus norvegicus Alpha-1d adrenergic receptor Ki 1659.59 nM 10.1021/jm030551a
Rattus norvegicus Alpha-1d adrenergic receptor Ki 1700.0 nM 10.1021/jm025550h
Rattus norvegicus Alpha-1d adrenergic receptor pD2 5.73 None 10.1021/jm030551a
Rattus norvegicus Alpha-2a adrenergic receptor Efficacy 20.0 % 10.1021/jm030551a
Rattus norvegicus Alpha-2a adrenergic receptor pD2 8.23 None 10.1021/jm030551a
Rattus norvegicus Alpha-2b adrenergic receptor Ki 1862.09 nM 10.1021/jm030551a
Rattus norvegicus Alpha adrenergic receptor 1A and 1B Selectivity 3.0 None 10.1021/jm030551a
Rattus norvegicus Alpha adrenergic receptor 1A and 1D Selectivity 0.8 None 10.1021/jm030551a
Rattus norvegicus Rattus norvegicus Efficacy 68.0 % 10.1021/jm025550h
Rattus norvegicus Rattus norvegicus Efficacy 106.0 % 10.1021/jm025550h
None ADMET CL 3.0 uL.min-1.(10^6cells)-1 10.6019/CHEMBL3301361
None ADMET PPB 21.99 % 10.6019/CHEMBL3301361
None Unchecked Ratio 1.3 None 10.1021/jm025550h
None Unchecked Selectivity 0.001 None 10.1021/jm030551a
None Unchecked Selectivity 0.7 None 10.1021/jm030551a
None Unchecked Selectivity 0.9 None 10.1021/jm030551a
None Unchecked Selectivity 1.0 None 10.1021/jm030551a
None Unchecked Selectivity 12.0 None 10.1021/jm030551a

Metabolism Information