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Farinosone A

AlkaPlorer ID: AK556144

Synonym: None

IUPAC Name: 3-[(2E,4E,6E,8E)-8,10-dimethyldodeca-2,4,6,8-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1H-pyridin-2-one

Structure

SMILES: CCC(C)/C=C(C)/C=C/C=C/C=C/C(=O)C1=C(O)N=CC(C2=CC=C(O)C=C2)=C1O

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InChI: InChI=1S/C25H27NO4/c1-4-17(2)15-18(3)9-7-5-6-8-10-22(28)23-24(29)21(16-26-25(23)30)19-11-13-20(27)14-12-19/h5-17,27H,4H2,1-3H3,(H2,26,29,30)/b6-5+,9-7+,10-8+,18-15+

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InChIKey: WCQOVQCOVLYQSA-PDOAJKQXSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 405.4940000000001

TPSA？: 90.65

MolLogP？: 5.709100000000007

Number of H-Donors: 3

Number of H-Acceptors: 5

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens Anandamide amidohydrolase IC50 1200.0 nM 10.1016/j.bmc.2017.02.031
Homo sapiens Anandamide amidohydrolase IC50 10000.0 nM 10.1016/j.bmc.2017.02.031
Homo sapiens Anandamide amidohydrolase Inhibition nan % 10.1016/j.bmc.2017.02.031
Homo sapiens Cannabinoid CB1 receptor Inhibition 20.0 % 10.1016/j.bmc.2017.02.031
Homo sapiens Cannabinoid CB1 receptor Ki 1000.0 nM 10.1016/j.bmc.2017.02.031
Homo sapiens Cannabinoid CB2 receptor Inhibition 20.0 % 10.1016/j.bmc.2017.02.031
Homo sapiens Cannabinoid CB2 receptor Ki 1000.0 nM 10.1016/j.bmc.2017.02.031
Homo sapiens Cyclooxygenase-2 IC50 10000.0 nM 10.1016/j.bmc.2017.02.031
Mus musculus Monoacylglycerol lipase ABHD12 Inhibition nan % 10.1016/j.bmc.2017.02.031
Mus musculus Monoacylglycerol lipase ABHD6 Inhibition nan % 10.1016/j.bmc.2017.02.031
Rattus norvegicus PC-12 Activity 10.0 % 10.1021/np049761w
Rattus norvegicus PC-12 Activity 30.0 % 10.1021/np049761w
Rattus norvegicus PC-12 Activity 40.0 % 10.1021/np049761w
Rattus norvegicus PC-12 Activity 60.0 % 10.1021/np049761w
Rattus norvegicus PC-12 Activity nan None 10.1021/np049761w
None Unchecked IC50 10000.0 nM 10.1016/j.bmc.2017.02.031
None Unchecked Inhibition nan % 10.1016/j.bmc.2017.02.031

Metabolism Information