Philanthotoxin-74
AlkaPlorer ID: AK581342
Synonym: None
IUPAC Name: N-[(2S)-1-[7-(4-aminobutylamino)heptylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]butanamide
Structure
SMILES: CCCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCCCCCCCNCCCCN
InChI: InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-8-5-3-4-7-16-26-17-9-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
InChIKey: YKCMCIWNASWOOP-QFIPXVFZSA-N
Reference
Antcamphorols A–K, Cytotoxic and ROS Scavenging Triterpenoids from <i>Antrodia camphorata</i>
PubChem CID: 10122460
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|
Properties Information
Molecule Weight: 434.6250000000005
TPSA？: 116.48
MolLogP？: 2.6148000000000007
Number of H-Donors: 5
Number of H-Acceptors: 5
RingCount: 1
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | Glutamate receptor AMPA 1/2 | Inhibition | 84.3 | % | 10.1016/j.bmc.2009.12.072 |
| Homo sapiens | Glutamate receptor AMPA 1/2 | Ki | 1600.0 | nM | 10.1016/j.bmc.2009.12.072 |
| Homo sapiens | Glutamate receptor AMPA 2/3 | Inhibition | 2.6 | % | 10.1016/j.bmc.2009.12.072 |
| Homo sapiens | Glutamate receptor ionotropic, AMPA 1 | Inhibition | 100.0 | % | 10.1016/j.bmc.2009.12.072 |
| Homo sapiens | Glutamate receptor ionotropic, AMPA 1 | Ki | 168.0 | nM | 10.1016/j.bmc.2009.12.072 |
| Homo sapiens | Glutamate receptor ionotropic, AMPA 2 | Inhibition | 2.1 | % | 10.1016/j.bmc.2009.12.072 |
| Homo sapiens | Glutamate receptor ionotropic, AMPA 3 | Inhibition | 100.0 | % | 10.1016/j.bmc.2009.12.072 |
| Rattus norvegicus | Glutamate receptor ionotropic, AMPA | IC50 | 138.0 | nM | 10.1021/jm060606j |
| Rattus norvegicus | Glutamate receptor ionotropic, AMPA 1 | Ki | 168.0 | nM | 10.1021/jm060606j |