Carquinostatin B
AlkaPlorer ID: AK585905
Synonym: None
IUPAC Name: 1-(1,2-dihydroxypropyl)-2-methyl-6-(3-methylbut-2-enyl)-9H-carbazole-3,4-dione
Structure
SMILES: CC(C)=CCC1=CC=C2NC3=C(C(=O)C(=O)C(C)=C3C(O)C(C)O)C2=C1
InChI: InChI=1S/C21H23NO4/c1-10(2)5-6-13-7-8-15-14(9-13)17-18(22-15)16(20(25)12(4)23)11(3)19(24)21(17)26/h5,7-9,12,20,22-23,25H,6H2,1-4H3
InChIKey: YUNXXJUUIKKYDM-UHFFFAOYSA-N
Reference
Carquinostatin B, a New Neuronal Cell-protecting Substance Produced by<i>Streptomyces exfoliatus</i>
PubChem CID: 380452
LOTUS: LTS0108081
COCONUT: CNP0144996.1
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces exfoliatus | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 353.418
TPSA？: 90.39
MolLogP？: 2.957200000000001
Number of H-Donors: 3
Number of H-Acceptors: 4
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | 786-0 | GI50 | 1866.38 | nM | None |
| Homo sapiens | A498 | GI50 | 12502.59 | nM | None |
| Homo sapiens | A549 | GI50 | 21827.3 | nM | None |
| Homo sapiens | ACHN | GI50 | 4265.8 | nM | None |
| Homo sapiens | CAKI-1 | GI50 | 4375.22 | nM | None |
| Homo sapiens | CCRF-CEM | GI50 | 1548.82 | nM | None |
| Homo sapiens | COLO 205 | GI50 | 2157.74 | nM | None |
| Homo sapiens | DU-145 | GI50 | 10471.29 | nM | None |
| Homo sapiens | EKVX | GI50 | 16143.59 | nM | None |
| Homo sapiens | HCC 2998 | GI50 | 6382.63 | nM | None |
| Homo sapiens | HCT-116 | GI50 | 1782.38 | nM | None |
| Homo sapiens | HCT-15 | GI50 | 2317.39 | nM | None |
| Homo sapiens | HL-60 | GI50 | 769.13 | nM | None |
| Homo sapiens | HOP-62 | GI50 | 20323.57 | nM | None |
| Homo sapiens | HOP-92 | GI50 | 1506.61 | nM | None |
| Homo sapiens | Hs-578T | GI50 | 15135.61 | nM | None |
| Homo sapiens | HT-29 | GI50 | 9332.54 | nM | None |
| Homo sapiens | IGROV-1 | GI50 | 2360.48 | nM | None |
| Homo sapiens | K562 | GI50 | 2065.38 | nM | None |
| Homo sapiens | KM12 | GI50 | 16481.62 | nM | None |
| Homo sapiens | LOX IMVI | GI50 | 1995.26 | nM | None |
| Homo sapiens | M14 | GI50 | 1905.46 | nM | None |
| Homo sapiens | Malme-3M | GI50 | 1778.28 | nM | None |
| Homo sapiens | MCF7 | GI50 | 1633.05 | nM | None |
| Homo sapiens | MDA-MB-231 | GI50 | 3539.97 | nM | None |
| Homo sapiens | MDA-MB-435 | GI50 | 2851.02 | nM | None |
| Homo sapiens | MDA-N | GI50 | 3061.96 | nM | None |
| Homo sapiens | MOLT-4 | GI50 | 1702.16 | nM | None |
| Homo sapiens | NCI/ADR-RES | GI50 | 15066.07 | nM | None |
| Homo sapiens | NCI-H226 | GI50 | 15100.8 | nM | None |
| Homo sapiens | NCI-H23 | GI50 | 5395.11 | nM | None |
| Homo sapiens | NCI-H322M | GI50 | 18620.87 | nM | None |
| Homo sapiens | NCI-H460 | GI50 | 14092.89 | nM | None |
| Homo sapiens | NCI-H522 | GI50 | 1686.55 | nM | None |
| Homo sapiens | OVCAR-3 | GI50 | 2958.01 | nM | None |
| Homo sapiens | OVCAR-4 | GI50 | 3715.35 | nM | None |
| Homo sapiens | OVCAR-5 | GI50 | 18365.38 | nM | None |
| Homo sapiens | OVCAR-8 | GI50 | 2128.14 | nM | None |
| Homo sapiens | PC-3 | GI50 | 9571.94 | nM | None |
| Homo sapiens | RPMI-8226 | GI50 | 1815.52 | nM | None |
| Homo sapiens | RXF 393 | GI50 | 2172.7 | nM | None |
| Homo sapiens | SF-268 | GI50 | 12882.5 | nM | None |
| Homo sapiens | SF-295 | GI50 | 12161.86 | nM | None |
| Homo sapiens | SF-539 | GI50 | 5984.12 | nM | None |
| Homo sapiens | SK-MEL-2 | GI50 | 8203.52 | nM | None |
| Homo sapiens | SK-MEL-28 | GI50 | 7194.49 | nM | None |
| Homo sapiens | SK-MEL-5 | GI50 | 2454.71 | nM | None |
| Homo sapiens | SK-OV-3 | GI50 | 16218.1 | nM | None |
| Homo sapiens | SN12C | GI50 | 8550.67 | nM | None |
| Homo sapiens | SNB-19 | GI50 | 16982.44 | nM | None |
| Homo sapiens | SNB-75 | GI50 | 17660.38 | nM | None |
| Homo sapiens | SR | GI50 | 2449.06 | nM | None |
| Homo sapiens | SW-620 | GI50 | 2094.11 | nM | None |
| Homo sapiens | T47D | GI50 | 2290.87 | nM | None |
| Homo sapiens | TK-10 | GI50 | 2517.68 | nM | None |
| Homo sapiens | U-251 | GI50 | 6025.6 | nM | None |
| Homo sapiens | UACC-257 | GI50 | 2055.89 | nM | None |
| Homo sapiens | UACC-62 | GI50 | 5520.77 | nM | None |
| Homo sapiens | UO-31 | GI50 | 1545.25 | nM | None |