A new alkaloid, nupharamine, was obtained from nuphar, a dried rhizome of Nuphar japonicum DC. The alkaloid comes as a colorless, viscous liquid of b.p1 130•134•‹, :-35.4•‹, C15112502N; forms a picrolonate of m.p. 167.5•168•‹, diacetyl compound •kƒ¿•l8D of b.p0.25 166•`169•‹, and N-methylnupharamine methiodide, m.p. 203.5•‹, on warm ing with methyl iodide. From its infrared spectrum, the presence of a - furan ring was presumed. This base is a secondary amine and possesses one hydroxyl and one bridged oxygen that forms the furan ring. Presence of two C-methyl groups was predicted in nupharamine.