Pentaketide Ansamycin Microansamycins A–I from Micromonospora sp. Reveal Diverse Post-PKS Modifications

Pentaketide Ansamycin Microansamycins A–I from <i>Micromonospora</i> sp. Reveal Diverse Post-PKS Modifications Heterologous Expression of a Cryptic Giant Type I PKS Gene Cluster Leads to the Production of Ansaseomycin Heterologous Expression of a Cryptic Giant Type I PKS Gene Cluster Leads to the Production of Ansaseomycin Activating a Cryptic Ansamycin Biosynthetic Gene Cluster To Produce Three New Naphthalenic Octaketide Ansamycins with <i>n</i>-Pentyl and <i>n</i>-Butyl Side Chains Activating a Cryptic Ansamycin Biosynthetic Gene Cluster To Produce Three New Naphthalenic Octaketide Ansamycins with <i>n</i>-Pentyl and <i>n</i>-Butyl Side Chains Targeted Discovery of Pentaketide Ansamycin Aminoansamycins A–G Targeted Discovery of Pentaketide Ansamycin Aminoansamycins A–G Structure and Biosynthesis of the Marine Streptomycete Ansamycin Ansalactam A and Its Distinctive Branched Chain Polyketide Extender Unit Structure and Biosynthesis of the Marine Streptomycete Ansamycin Ansalactam A and Its Distinctive Branched Chain Polyketide Extender Unit Ansalactams B–D Illustrate Further Biosynthetic Plasticity within the Ansamycin Pathway