Pyrichalasin H, a new phytotoxic metabolite belonging to the cytochalasans from Pyricularia grisea (Cooke) Saccardo.

Agricultural and Biological Chemistry
1987.0

Abstract

In continuing chemical studies of metabolites produced by the fungi belonging to the genus Pyricularia, a new phytotoxic metabolite named pyrichalasin H (1) was isolated from the fungus Pyricularia grisea (Cooke) Saccardo IFO 7287. Pyrichalasin H was found to strongly inhibit the growth of rice seedlings and at 1 μg/ml (1.9×10⁻⁶ M), characteristic curling of the shoot was observed as shown in Fig. 1. In this communication, the isolation and structural determination of pyrichalasin H is reported.

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