Annona reticulata L. (Annonaceae), a tree of dry tropical forests probably originating in Central America and now cultivated throughout the tropics, has long been known as a source of 1-benzyltetrahydroisoquinoline alkaloids and recently reported to yield an acetogenin. While several Annona species have yielded diterpenes, they have not previously been found in A. reticulata. In this paper, we report the isolation of several kaurane diterpenes, some novel, from the stem bark of this species. Column chromatography of an EtOAc extract over Si gel eluting with petroleum ether-EtOAc mixtures yielded seven bands (A-G). Bands A and C were identified as (-)-kaur-16-en-19-oic acid [1] and (-)-kauran-16α-ol [2] (both previously reported from other Annona species), Band B as caryophyllene-4,5-oxide, and Band G as an acetogenin. Band F was characterized as the novel methyl 16β,17-dihydroxy-(-)-kauran-19-oate [7]. Band D contained a 50:50 mixture of new natural products methyl 17-hydroxy-16β-(-)-kauran-19-oate [12] and methyl 17-hydroxy-16α-(-)-kauran-19-oate [13], while Band E yielded their corresponding acids 16 and 17 (known from other families but new to Annonaceae). Both 1 and 2 have been reported from other Annona species, but the remaining compounds are new to the Annonaceae. The 50:50 mixtures of 12/13 and 16/17 are unusual, as 7 (presumably from the same 16,17-oxide intermediate) is a single isomer, suggesting 7 may be enzyme-controlled while the mixtures result from nonenzymatic fission of the oxide precursor.