<jats:title>Significance</jats:title> <jats:p> Bacterially produced small molecules are indispensable leads in the development of antibiotics, anticancer therapeutics, or immunomodulators. To unveil novel aspects in the biosynthetic potential of bacteria, a consideration of the ecological context in which the adapted producers thrive is extremely insightful. Here, we describe two natural products produced by <jats:italic>Pseudomonas</jats:italic> sp. QS1027, a bacterium that resides in the vicinity of the bacterial predator <jats:italic>Dictyostelium discoideum</jats:italic> . The two metabolites are jessenipeptin, a nonribosomal cyclic lipopeptide, and mupirocin, a known polyketide antibiotic. Both compounds are quorum-sensing regulated and display potent synergistic inhibitory activity against clinically relevant methicillin-resistant <jats:italic>Staphylococcus aureus</jats:italic> (MRSA).