Two new compounds, 3-(4-methoxy-3-methyl-2-oxo-2H-pyran-6-yl)butyl pyroglutamate (1) and 2,2′-(1,1′-methylenebis(1H-indole-3,1-diyl)) diethanol (2), were isolated from the endophytic fungus of Cephalotaxus hainanensis. Their structures were determined by means of chemical and spectroscopic analysis. © 2011 Taylor & Francis.