Isolation and structural determination of siderochelin C, a fermentation product of an unusual Actinomycetes sp.

The Journal of Antibiotics
1984.0

Abstract

From the fermentation products of a new actinomycete (Abbott strain 69-209B-89), isolated from a Philippine soil sample, we have isolated phenylacetamide (1), the previously known antibiotics siderochelins A (2) and B (3),1,2) and a new component; C12H15N3O3, mp 168~171'C, designated siderochelin C (4), which is shown here to be (2S,4R)-3,4-dihydro-4-ethyl-4 hydroxy-5-(3-hydroxy-2-pyridyl)-2H-pyrrole-2 carboxamide (4), a higher homologue of siderochelin A. In the course of this work we have also confirmed the structure and established the solid state conformation of siderochelin B by single crystal X-ray analysis.

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