A new indole alkaloid and new C-19 and C-20 skeleton quassinoids were isolated from the wood of Ailanthus malabarica. Their structures were determined by spectroscopic and X-ray analysis. In addition, six known alkaloids, canthin-6-one, canthin-6-one-3-N-oxide, 1-hydroxycanthin-6-one, 1-ethyl-beta-carboline, 1-ethyl-4-methoxy-beta-carboline,and beta-carboline-1-propionic acid, and a quassinoid, chaparrinone, were also identified.