Effects of Ym-51084 and Ym-51085, New Inhibitors Produced byStreptomyces Sp. Q21705, on Cathepsin L

Journal of Enzyme Inhibition
1996.0

Abstract

The structures of YM-51084 and YM-51085, new protease inhibitors produced by Streptomyces sp. Q21705, were determined by 1H- and 13C-NMR and mass spectrometry. Both were characterized by the basic structures of an acy tripeptide. YM-51084 was elucidated to be isovaleryl-tyrosyl-valylphenylalaninal and YM-51085 was the reduced phenylalaninol form of YM-51084. These compounds proved to strongly inhibit human kidney cathepsin L; the IC50 values being 9.6 x 10-9M and 3.5 x 10-8M, respectively.

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