The new bis-indole alkaloids tabernaemontabovine (1) and tabernaemontavine (2) have been isolated from aerial parts of Tabernaemontana bovina. Species of the genus Tabernaemontana, belonging to the family of Apocynaceae, are a rich source for various types of indole alkaloids [1– 4] and are widely used in the folk medicine [4]. The species Tabernaemontana bovina Lour., a ca. 1 m high shrub growing in Cochinchina [5], is used in the traditional medicine of Vietnam. Especially the roots are applied for the treatment of fever and jaundice [6]. Recently, we reported the structural elucidation of the novel indole alkaloids 3 oxomehranine and 14α,15β-dihydroxy-N-methylaspidospermine [7] as well as the bis-indole alkaloids tabernaebovine and methylenebismehranine [8], isolated besides a series of already known members from aerial parts of T. bovina. In the present study the identification of two further new bis-indole alkaloids, named tabernaemontabovine (1) and tabernaemontavine (2) from the same plant source is described. Their structures have been assigned on the basis of APT, 1H-1H DQF COSY, gradient-selected HSQC and gradient-selected HMBC-spectra.