Sphaerialactonam, a γ-lactam–isochromanone from the Hawaiian endophytic fungus Paraphaeosphaeria sp. FT462

Tetrahedron Letters
2017.0

Abstract

Reinvestigation of the endophytic fungus Paraphaeosphaeria sp. FT462 from the Hawaiian plant Lycopodiella cernua (L.) Pic. Serm led to the isolation and identification of a unique -lactamisochromanone (1). The structure of 1 was determined by NMR, MS spectroscopic analysis, and quantum chemical calculations of NMR. The compound was tested inactive against A2780 and A2780cisR.

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