Periconiasin G, a new cytochalasan with unprecedented 7/6/5 tricyclic ring system from the endophytic fungus Periconia sp.

Tetrahedron Letters
2016.0

Abstract

Two new cytochalasans, periconiasin G (1) and periconiasin H (2) were isolated from endophytic fungus Periconia sp. F-31. Compound 1 is the first cytochalasan with a 7/6/5 tricyclic ring system, and compound 2 possesses a rare sulfoxide group. Their structures including absolute configurations were elucidated by extensive spectroscopic analyses and ECD calculations. A possible biogenetic pathway for these two compounds was proposed. Compound 1 showed weak anti-HIV activity with IC50 value of 67.0 lM.

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