Structure elucidation of four prenylindole derivatives from Streptomyces sp. isolated from Ailuropoda melanoleuca feces

Abstract

<jats:p>Four new prenylindole derivatives, (<jats:italic>R</jats:italic>)‐6‐(2,3‐dihydroxy‐3‐methylbutyl)indole (1), (<jats:italic>R</jats:italic>)‐6‐(2,3‐dihydroxy‐3‐methylbutyl)indolin‐2‐one (2), and an unseparated mixture of (<jats:italic>Z</jats:italic>)‐6‐(4‐hydroxy‐3‐methylbut‐2‐en‐1‐yl)indolin‐2‐one (3a) and (<jats:italic>E</jats:italic>)‐6‐(4‐hydroxy‐3‐methylbut‐2‐en‐1‐yl)indolin‐2‐one (3b) with a ratio of 3 : 2, were isolated from the culture broth of a streptomycete isolated from <jats:italic>Ailuropoda melanoleuca</jats:italic> feces. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic techniques. The absolute configuration of 1 was determined by Mosher's method. Copyright © 2013 John Wiley &amp; Sons, Ltd.