The terrestrial cyanophyte Scytonema mirabile (Dillwyn) Bornet (strain BY-8-1) produces a complex mixture of cytotoxins, the major and most potent one being tolytoxin. Interestingly, some of the cytotoxins in the lipophilic extract of this alga show marginal solid tumor selectivity at the cellular level in the Corbett assay. We report here the total structures of tantazoles A (l), B (2), F (3), and I (4), representatives of an unusual class of alkaloids that exhibit murine solid tumor selective cytotoxicity. Recently we reported a second-generation synthesis of (-)-paspaline (l), the simplest member of a family of architecturally novel indole diterpenes. Central to the former was the development of a unified strategy, designed to encompass this entire class of fungal metabolites which now include (+)-paspalicine (2), (+)-paspalinine (3), and (+)-paxilline (4) (Scheme I). The cornerstone of the approach comprised a stereocontrolled, nine-step construction of tricyclic ketone (-)-5 [9.4% overall yield from (+)-Wieland-Miescher ketone], a prospective common intermediate containing the critical C(12b,12c) vicinal quaternary centers. In this communication we demonstrate the viability of this unified strategy with the first total syntheses of (+)-paspalicine (2) and (+)-paspalinine (3). Importantly, the potent tremorgen (+)-paspalinine represents the first biologically active indole diterpene to yield to total synthesis.