Glánvillic acids A (2) and B (3) and the cytotoxic cyclic peroxides methyl capucinoate A (4) and 5 were isolated from the Dominican marine sponges Plakortis halichondrioides and Plakinastrella onkodes, respectively. The structures have been elucidated by spectroscopic analysis of 4 and 5 and of methyl glánvillates A (6) and B (7).