Structure of cyclothiazomycin, a unique polythiazole-containing peptide with renin inhibitory activity. Part 1. Chemistry and partial structures of cyclothiazomycin

Tetrahedron Letters
1991.0

Abstract

Cyclothiazomycin is a novel renin inhibitor produced by Streptomyces sp. NR 0.516 (IC50 1.66 μM). Its molecular formula was determined to be C59H64N18O14S7 (MW 1472) based on high-resolution FAB mass and NMR spectroscopy. Five fragments of cyclothiazomycin containing thiazole, thiazoline, and heterocyclic chromophore were clarified by extensive 2D-NMR experiments.

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