Four new metabolites, nocarasins A-C (1-3) and brasiliquinone D (4), have been isolated from the actinomycete Nocardia brasiliensis IFM 0667, and the structures were elucidated on the basis of spectroscopic data and chemical means. Nocarasins A-C (1-3) and brasiliquinone D (4) exhibited cytotoxicity and antibacterial activity.