<jats:title>Abstract</jats:title><jats:p>Seven new cyclohexadepsipeptides, beauvenniatins F, G<jats:sub>1</jats:sub>, G<jats:sub>2</jats:sub>, G<jats:sub>3</jats:sub>, H<jats:sub>1</jats:sub>, H<jats:sub>2</jats:sub>, and H<jats:sub>3</jats:sub> (<jats:bold>1</jats:bold>–<jats:bold>7</jats:bold>, resp.), were isolated from cultures of the fungus <jats:italic>Acremonium</jats:italic> sp. BCC 2629. Their structures were elucidated by extensive spectroscopic analyses. The absolute configurations were addressed by HPLC analyses of their acid hydrolysates. Their biological activities were evaluated against <jats:italic>Mycobacterium tuberculosis</jats:italic> H37Ra and <jats:italic>Plasmodium falciparum</jats:italic> K1; the respective <jats:italic>MIC</jats:italic> and <jats:italic>IC</jats:italic><jats:sub>50</jats:sub> values were in the micromolar range.