1. From the epigeal part of Vinca major have been isolated the known bases akuammicine, vincamajine, vincamajoridine, and ervine, and the new alkaloid majorinine with the composition C22H24N2O4, mp 195-196°C. 2. On the basis of chemical transformations and IR, UV, mass, and PMR spectra using the methods of double resonance collapse and INDOR the structure of 21-hydroxy-10-methoxyvinorine and the stereochemistry (I) have been established for majorinine. © 1977 Plenum Publishing Corporation.