Four novel indole alkaloids: (I?) N-(3-methoxy-4-hydroxycinnamoyl)-5 hydroxytryptamine (moschamine, l), (Z) N-(3-methoxy-4-hydroxycinnamoyl)-5-hydroxytryptamine (cis-moschamine, t), {2-(3-methoxy-4-hydroxyphenyl)}-dihydrofuro[kT]-1N-pyrrolo[fg]-2-ox~ 1,2,3,4,5,6-hexahydro-3-benzocine (moschamindole, 3) and 1-(3-methoxy-4,7-d1hydroxybenzyl)- 10-hydroxy- lH-pyrrolo[fg]-2-oxol.2,3,4,5,6-hexahydro-3-benzamcine (moschamindolol, 4) have been isolated from the seeds of Centaureu rnoschata. The structures of these compounds have been determined primarily on the basis of extensive 1D and 2D NMR experiments.