Strongylophorines, meroditerpenoids from the marine sponge Petrosia corticata, function as proteasome inhibitors

Bioorganic & Medicinal Chemistry Letters
2015.0

Abstract

Two new strongylophorine derivatives, along with six known strongylophorines, were isolated from the marine sponge Petrosia corticata as proteasome inhibitors. Of these, a hemiacetal mixture of strongylophorines-13/-14 was the strongest inhibitor of the proteasome with an IC50 of 2.1μM.

Knowledge Graph

Similar Paper

Strongylophorines, meroditerpenoids from the marine sponge Petrosia corticata, function as proteasome inhibitors
Bioorganic & Medicinal Chemistry Letters 2015.0
Strongylophorine-26, a New Meroditerpenoid Isolated from the Marine Sponge <i>Petrosia (Strongylophora) corticata</i> That Exhibits Anti-invasion Activity
Journal of Natural Products 2004.0
Strongylophorines, new protein tyrosine phosphatase 1B inhibitors, from the marine sponge Strongylophora strongilata collected at Iriomote Island
Bioorganic &amp; Medicinal Chemistry Letters 2015.0
New Polyhydroxy Sterols:  Proteasome Inhibitors from a Marine Sponge <i>Acanthodendrilla </i>sp.
Journal of Natural Products 2003.0
Tetradehydrohalicyclamine B, a new proteasome inhibitor from the marine sponge Acanthostrongylophora ingens
Bioorganic &amp; Medicinal Chemistry Letters 2019.0
A New Meroditerpenoid Dimer from an Undescribed Philippine Marine Sponge of the Genus<i>Strongylophora</i>
Journal of Natural Products 1998.0
Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor
Bioorganic &amp; Medicinal Chemistry Letters 2010.0
Corticatic Acids D and E, Polyacetylenic Geranylgeranyltransferase Type I Inhibitors, from the Marine Sponge <i>Petrosia</i> <i>c</i><i>orticata</i>
Journal of Natural Products 2002.0
A tetramic acid derivative with protein tyrosine phosphatase 1B inhibitory activity and a new nortriterpene glycoside from the Indonesian marine sponge Petrosia sp.
Bioorganic &amp; Medicinal Chemistry Letters 2017.0
Corticatic Acids A-C, Antifungal Acetylenic Acids from the Marine Sponge, Petrosia corticata
Journal of Natural Products 1994.0