Literature

Abstract

<jats:title>ABSTRACT</jats:title> <jats:p> A mutation in <jats:italic>act</jats:italic> VI-ORF1, which controls C-3 reduction in actinorhodin biosynthesis by <jats:italic>Streptomyces coelicolor</jats:italic> , was complemented by <jats:italic>gra</jats:italic> -ORF5 and -ORF6 from the granaticin biosynthetic gene cluster of <jats:italic>Streptomyces violaceoruber</jats:italic> Tü22. It is hypothesized that, while <jats:italic>gra</jats:italic> -ORF5 alone is a ketoreductase for C-9, <jats:italic>gra</jats:italic> -ORF6 gives the enzyme regiospecificity also for C-3.

DOI： 10.1128/JB.183.10.3247-3250.2001

Functional Complementation of Pyran Ring Formation in Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2) by Ketoreductase Genes for Granaticin Biosynthesis

Journal of Bacteriology 2001.0

A New Mode of Stereochemical Control Revealed by Analysis of the Biosynthesis of Dihydrogranaticin in Streptomyces violaceoruber Tü22

Journal of the American Chemical Society 2001.0

Functional replacement of genes for individual polyketide synthase components in Streptomyces coelicolor A3(2) by heterologous genes from a different polyketide pathway

Journal of Bacteriology 1992.0

Chemical Characterisation of Disruptants of the Streptomyces coelicolor A3(2). ActVI Genes Involved in Actinorhodin Biosynthesis.

The Journal of Antibiotics 2000.0

Identification of Four Genes from the Granaticin Biosynthetic Gene Cluster of Streptomyces violaceoruber Tue22 Involved in the Biosynthesis of L-Rhodinose.

The Journal of Antibiotics 2001.0

The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tü22: sequence analysis and expression in a heterologous host