Terebenthifolic acid and bauerenone: New triterpenoid ketones from Schinus terebenthifolius

Phytochemistry
1975.0

Abstract

Studies of the terpene constituents of Schinus terebenthifolius Raddi, commonly known as Aroeira, have led to the isolation of schinol [1--4], masticadienonic acid [3], sitosterol, triacontane, and simiarenol [4]. This note describes the isolation of additional triterpenes and their characterization by chemical and spectral methods; The alcoholic extract of the roots of Curissa carundus L. has been reported to possess cardiotonic activity [1] and to produce a perceptible decrease in blood pressure in normal anaesthetized cats [2]. Chemical studies have led to the isolation of possibly a new cardioactive substance [3]; glucosides of odoroside H [4]. a new terpenoid carindone [S] besides carissone, lupeol, ursolic acid and its methyl ester [6]. A recent investigation of the pharmacological activity [7] of the extract showed an increase in free histamine in the guinea pig lung and a pronounced decrease in blood pressure at 1 mg/kg dose which lasted for 4-5 hr. On fractionation of the extract, the hypotensive activity was found to be localized in the C,H,-soluble fraction which prompted further examination of its constituents.

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