Cadinane-type sesquiterpenoids and an indolizine alkaloid from the rice fermentation of the fungus Rigidoporus microporus

Phytochemistry Letters
2019.0

Abstract

Two previously undescribed cadinane-type sesquiterpenoids, rigidoporones A and B (1 and 2), along with an undescribed racemic indolizine alkaloid, ( ± )-rigidoporine A (3), were isolated from the rice fermentation of the wood-decay fungus Rigidoporus microporus. The structures of the compounds were established by extensive spectroscopic methods, including 1D & 2D NMR and HRMS spectroscopic analysis. Compounds 1 and 3 were evaluated for their inhibitory activity on NO production in murine monocytic RAW264.7 macrophages (IC50 > 25 μM).

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