A new lignanamide, named cannabisin A, a known lignanamide, grossamide, and three known amides, N-trans-caffeoyltyramine, N-[trans-feruloyltyramine, N-p-coumaroyltyramine, were isolated from the fruits of Cannabis sativa. The structure of cannabisin A has been established as 6,7-dihydroxy-1-(3,4-dihydroxyphenyl)-N',N'-bis-[2-(4-hydroxyphenyl)ethyl]-2,3-naphthalenedicarboxamide, on the basis of chemical and spectral evidence.