Two new alkaloids possessing the 1-phenylethyltetrahydroisoquinoline skeleton, dysoxyline (1) and S-(+)-homolaudanosine (2), have been isolated from Dysoxylum lenticellare Gillespie (family Meliaceae) along with known homoerythrina alkaloids 3-epischelhammericine (3) and 2,7-dihydrohomoerysotrine (4). Also isolated was a new alkaloid with a novel dibenz[d,f]azecine skeleton, dysazecine (5). The macrocycle 5 represents the trapping of a biosynthetic intermediate in the postulated conversion of the phenylethylisoquinoline skeleton to the homoerythrina skeleton. None of these alkaloid skeleta have been found previously in plants of the Meliaceae. The genus Dysoxylum of the family Meliaceae is comprised of about 60 species of trees in Polynesia and Indomalaysia. Phytochemical screening of many species of Dysoxylum has indicated that some contain alkaloids (1-3); however, no chemical structures have been determined. We report here the first structure determinations of alkaloids from the genus which were isolated from D. lenticellare Gillespie grown in the Fiji Islands.