Continuing our investigations on medicinal plants of the Egyptian desert, two new triterpene glycoside derivatives, along with three known compounds have been isolated from the roots of Salsola imbricata, a shrub widely growing in Egypt. Their structures have been established as 3-O-b-D-xylopyranosyl- (1 ! 2)-O-b-D-glucuronopyranosyl-akebonic acid 28-O-b-D-glucopyranoside and 3-O-b-D-xylopyranosyl-(1 ! 2)-O-b-D-glucuronopyranosyl-29-hydroxyoleanolic acid 28-O-b-D-glucopyranoside on the basis of spectroscopic methods including 1D- ( 1 H, 13C) and 2D-NMR (DQF-COSY, HSQC, HMBC) experiments as well as mass spectrometry analysis.