Cocculine, isoboldine, norisoboldine, and a new erythrinan alkaloid, coclafine, for which the structure and absolute configuration of 3S,5R-3,15-dihydroxyerythrin-Δ1(6)-ene have been established, have been isolated from the leaves of Cocculus laurifolius DC. © 1991 Plenum Publishing Corporation.