As part of a program to isolate potential antineoplastic agents from plants, an ethanolic extract of Rollinia papilionella Diels. (Annonaceae) was found to exhibit significant activity in vivo and in vitro against the P-388 lymphocytic leukemia (1). During the course of fractionation of this extract guided by cytotoxicity against the P-388 cell culture, three known oxoaporphine alkaloids-liriodenine, lanuginosine, and lysicamine-were isolated. These alkaloids are not the major cytotoxic constituents of R. papilionella, but this is apparently the first report of their isolation from a Rollinia species.